ArticleAmerican journal of epidemiology2021
Early-Life Socioeconomic Position and the Accumulation of Health-Related Deficits by Midlife in the 1958 British Birth Cohort Study.
Article in American journal of epidemiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed.
- Non-genetic component of height as a surrogate marker for childhood socioeconomic position and its association with cardiovascular and brain health: results from HCHS/SOL.medRxiv : the preprint server for health sciences · 2026Article
- Life-course socio-economic factors associated with frailty in later life.The Journal of frailty & aging · 2025Article
- Adult Socioeconomic Position Mediates the Association Between Childhood Socioeconomic Position and Later-Life Frailty Trajectory: A Nationally Representative Cohort Study.Innovation in aging · 2025Article
- Childhood socioeconomic position and healthy ageing: results from five harmonised cohort studies in the ATHLOS consortium.BMJ public health · 2025Article
- Gaps in the usage and reporting of multiple imputation for incomplete data: findings from a scoping review of observational studies addressing causal questions.BMC medical research methodology · 2024Article
- Association of Childhood Adversity With Frailty and the Mediating Role of Unhealthy Lifestyle: A Lifespan Analysis.The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry · 2024Article
- Childhood and adult socioeconomic status influence on late-life healthy longevity: evidence from the Chinese longitudinal healthy longevity survey.Frontiers in public health · 2024Article
- Association of childhood adversity with frailty and the mediating role of unhealthy lifestyle: Findings from the UK biobank.medRxiv : the preprint server for health sciences · 2023Article
- Early-Life Factors as Predictors of Age-Associated Deficit Accumulation Across 17 Years From Midlife Into Old Age.The journals of gerontology. Series A, Biological sciences and medical sciences · 2022Article
- Contribution of life course circumstances to the acceleration of phenotypic and functional aging: A retrospective study.EClinicalMedicine · 2022Article
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Authors and funding
6 authors.
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Abstract
Reducing population levels of frailty is an important goal, and preventing its development in midadulthood could be pivotal. There is limited evidence on associations between childhood socioeconomic position (SEP) and frailty. Using data on the 1958 British birth cohort (followed from 1958 to 2016; n = 8,711), we aimed to 1) establish the utility of measuring frailty in midlife, by examining associations between a 34-item frailty index at age 50 years (FI50y) and mortality at ages 50-58 years, and 2) examine associations between early-life SEP and FI50y and investigate whether these associations were explained by adult SEP. Hazard ratios for mortality increased with increasing frailty; for example, the sex-adjusted hazard ratio for the highest quintile of FI50y versus the lowest was 4.07 (95% confidence interval (CI): 2.64, 6.25). Lower early-life SEP was associated with higher FI50y. Compared with participants born in the highest social class, the estimated total effect on FI50y was 42.0% (95% CI: 35.5, 48.4) for participants born in the lowest class, with the proportion mediated by adult SEP being 0.45% (95% CI: 0.35, 0.55). Mediation by adult SEP was negligible for other early-life SEP classes. Findings suggest that early-life SEP is associated with frailty and that adult SEP only partially explains this association. Results highlight the importance of improving socioeconomic circumstances across the life course to reduce inequalities in midlife frailty.
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