ArticlePlant physiology2021
Insights into the mechanisms of transport and regulation of the arabidopsis high-affinity K+ transporter HAK51.
Article in Plant physiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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21 citing papers in PubMed, 51 citations in OpenAlex.
- ExtremohalophilicPlant signaling & behavior · 2026Article
- Article
- Potassium Deficiency and Hormone Signalling in Plants.Plant, cell & environment · 2026Review
- The VvSAP8-VvHAK5 module from grape confers dual tolerance to potassium deficiency and salt stress by regulating potassium transport.Plant cell reports · 2026Article
- Transcriptomic prey-capture responses in convergently evolved carnivorous pitcher plants.The New phytologist · 2026Article
- Molecular mechanisms and evolutionary adaptations of transporters for photosynthates and specialized metabolites in plants.Plant cell reports · 2026Review
- The Role of Potassium and KUP/KT/HAK Transporters in Regulating Strawberry (Plants (Basel, Switzerland) · 2025Article
- Identification, classification, and stress-responsive regulation ofFrontiers in plant science · 2025Article
- Arabidopsis HAK5 under low KNature communications · 2024Article
- Integrative gene duplication and genome-wide analysis as an approach to facilitate wheat reverse genetics: An example in the TaCIPK family.Journal of advanced research · 2024Article
- Positive Regulatory Roles ofPlants (Basel, Switzerland) · 2024Article
- Structural basis for the activity regulation of Salt Overly Sensitive 1 in Arabidopsis salt tolerance.Nature plants · 2023Article
- Identification and Functional Characterization ofInternational journal of molecular sciences · 2023Article
- Salt-tolerant alternative crops as sources of quality food to mitigate the negative impact of salinity on agricultural production.Frontiers in plant science · 2023Review
- Identification of phosphorylation site using S-padding strategy based convolutional neural network.Health information science and systems · 2022Article
- Structural basis for the activity regulation of a potassium channel AKT1 from Arabidopsis.Nature communications · 2022Article
- An endoplasmic reticulum-localized cytochromeProceedings of the National Academy of Sciences of the United States of America · 2021Article
- Regulation of Cytosolic pH: The Contributions of Plant Plasma Membrane HInternational journal of molecular sciences · 2021Review
- Adjustment of KInternational journal of molecular sciences · 2021Review
- Harnessing a Transient Gene Expression System inPlants (Basel, Switzerland) · 2021Article
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10 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The high-affinity K+ transporter HAK5 from Arabidopsis (Arabidopsis thaliana) is essential for K+ acquisition and plant growth at low micromolar K+ concentrations. Despite its functional relevance in plant nutrition, information about functional domains of HAK5 is scarce. Its activity is enhanced by phosphorylation via the AtCIPK23/AtCBL1-9 complex. Based on the recently published three-dimensionalstructure of the bacterial ortholog KimA from Bacillus subtilis, we have modeled AtHAK5 and, by a mutational approach, identified residues G67, Y70, G71, D72, D201, and E312 as essential for transporter function. According to the structural model, residues D72, D201, and E312 may bind K+, whereas residues G67, Y70, and G71 may shape the selective filter for K+, which resembles that of K+shaker-like channels. In addition, we show that phosphorylation of residue S35 by AtCIPK23 is required for reaching maximal transport activity. Serial deletions of the AtHAK5 C-terminus disclosed the presence of an autoinhibitory domain located between residues 571 and 633 together with an AtCIPK23-dependent activation domain downstream of position 633. Presumably, autoinhibition of AtHAK5 is counteracted by phosphorylation of S35 by AtCIPK23. Our results provide a molecular model for K+ transport and describe CIPK-CBL-mediated regulation of plant HAK transporters.
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