Evidence map›Paper›PMID 33595051›Full record

ArticleSoft matter2021

Moving while you're stuck: a macroscopic demonstration of an active system inspired by binding-mediated transport in biology.

Kanghyeon Koo, Shankar Lalitha Sridhar, Noel Clark, Franck Vernerey, Loren Hough

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Soft matter, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Kanghyeon KooCivil, Environmental and Architectural Engineering, University of Colorado Boulder, Boulder, CO 80309, USA.
Shankar Lalitha SridharMechanical Engineering, University of Colorado Boulder, Boulder, CO 80309, USA. franck.vernerey@colorado.edu and BioFrontiers Institute, University of Colorado, Boulder, USA.
Noel ClarkDepartment of Physics, University of Colorado Boulder, Boulder, CO 80309, USA. loren.hough@colorado.edu.
Franck VernereyMechanical Engineering, University of Colorado Boulder, Boulder, CO 80309, USA. franck.vernerey@colorado.edu.ORCID http://orcid.org/0000-0001-6138-1431
Loren HoughBioFrontiers Institute, University of Colorado, Boulder, USA and Department of Physics, University of Colorado Boulder, Boulder, CO 80309, USA. loren.hough@colorado.edu.ORCID http://orcid.org/0000-0002-1104-0126

Funding

Molecular dissection of the C-terminal tails of tubulin and the effect of their polyglycylation on binding and microtubule assemblyR35GM119755 · NIGMS · UNIVERSITY OF COLORADO · PI HOUGH, LOREN E · 2016 to 2020
$1.8M
NIGMS NIH HHS R35 GM119755
6 · The paper itself

Abstract

Diffusive motion is typically constrained when particles bind to the medium through which they move. However, when binding is transient and the medium is made of flexible filaments, each association or dissociation event produces a stochastic force that can overcome the medium stickiness and enable motion. This mechanism is amply used by biological systems where the act of balancing binding and displacement robustly achieves key functionalities, including bacterial locomotion or selective active filtering in cells. Here we demonstrate the feasibility of making a dynamic system with macroscopic features, in which analogous binding-mediated motion can be actively driven, precisely tuned, and conveniently studied. We find an optimal binding affinity and number of binding sites for diffusive motion, and an inverse relationship between viscosity and diffusivity.

Indexed as

BiologyLocomotionDiffusionMotionViscosity

Identifiers

PMID33595051
PMCPMC9205265

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.