Evidence map›Paper›PMID 33595004›Full record

ReviewChemical Society reviews2021

Phenolic-enabled nanotechnology: versatile particle engineering for biomedicine.

Di Wu, Jiajing Zhou, Matthew N Creyer, Wonjun Yim, Zhong Chen, Phillip B Messersmith, Jesse V Jokerst

Abstract readReview
In one paragraph

Review in Chemical Society reviews, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 76 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
76citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

76 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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  18. Cooperative Lewis Acid/Metal Dual Catalysis for the SelectiveACS sustainable chemistry & engineering · 2025
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16 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Di WuCollege of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, China. chenzhong@zju.edu.cn.
Jiajing Zhou
Matthew N Creyer
Wonjun Yim
Zhong Chen
Phillip B Messersmith
Jesse V Jokerst

Funding

Biologically Inspired Polymer AdhesivesR37DE014193 · NIDCR · UNIVERSITY OF CALIFORNIA BERKELEY · PI MESSERSMITH, PHILLIP B · 2006 to 2015
$3.5M
Therapeutic Drug Monitoring with a Wearable Ultrasound-based SensorDP2HL137187 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI JOKERST, JESSE VINCENT · 2016 to 2019
$2.7M
Bioinspired Polymers for Fetal Membrane Pre-SealingR01EB022031 · NIBIB · UNIVERSITY OF CALIFORNIA BERKELEY · PI MESSERSMITH, PHILLIP B · 2016 to 2019
$1.3M
Cancer Researchers in Nanotechnology (CRIN)T32CA153915 · NCI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI KUMMEL, ANDREW CLYDE, ZHANG, DONG-ER · 2017 to 2021
$994k
Molecular Imaging of Gingipain Activity in Advanced PeriodontitisR21DE029917 · NIDCR · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI JOKERST, JESSE VINCENT · 2020 to 2021
$406k
NCI NIH HHS T32 CA153915NHLBI NIH HHS DP2 HL137187NIBIB NIH HHS R01 EB022031NIDCR NIH HHS R21 DE029917NIDCR NIH HHS R37 DE014193
6 · The paper itself

Abstract

Phenolics are ubiquitous in nature and have gained immense research attention because of their unique physiochemical properties and widespread industrial use. In recent decades, their accessibility, versatile reactivity, and relative biocompatibility have catalysed research in phenolic-enabled nanotechnology (PEN) particularly for biomedical applications which have been a major benefactor of this emergence, as largely demonstrated by polydopamine and polyphenols. Therefore, it is imperative to overveiw the fundamental mechanisms and synthetic strategies of PEN for state-of-the-art biomedical applications and provide a timely and comprehensive summary. In this review, we will focus on the principles and strategies involved in PEN and summarize the use of the PEN synthetic toolkit for particle engineering and the bottom-up synthesis of nanohybrid materials. Specifically, we will discuss the attractive forces between phenolics and complementary structural motifs in confined particle systems to synthesize high-quality products with controllable size, shape, composition, as well as surface chemistry and function. Additionally, phenolic's numerous applications in biosensing, bioimaging, and disease treatment will be highlighted. This review aims to provide guidelines for new scientists in the field and serve as an up-to-date compilation of what has been achieved in this area, while offering expert perspectives on PEN's use in translational research.

Indexed as

Biomedical ResearchNanotechnologyParticle SizePhenolsPhenols

Identifiers

PMID33595004
PMCPMC8106539

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.