ArticleeLife2021
Theory for the optimal detection of time-varying signals in cellular sensing systems.
Article in eLife, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
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Who cites it
11 citing papers in PubMed, 2 citations in OpenAlex.
- Invariant nonequilibrium dynamics in gene regulation optimize information flow.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
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- Slower swimming promotes chemotactic encounters between bacteria and small phytoplankton.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Trade-offs in concentration sensing in dynamic environments.Biophysical journal · 2024Article
- Sensing a moving target: A new model reveals how cells sense dynamic signals.Biophysical journal · 2024Article
- Trade-offs between cost and information in cellular prediction.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Cells function as a ternary logic gate to decide migration direction under integrated chemical and fluidic cues.Lab on a chip · 2023Article
- A synthetic synthesis to explore animal evolution and development.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2022Review
- Evolution of Complex Regulation for Cell-Cycle Control.Genome biology and evolution · 2022Article
- Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Living cells often need to measure chemical concentrations that vary in time, yet how accurately they can do so is poorly understood. Here, we present a theory that fully specifies, without any adjustable parameters, the optimal design of a canonical sensing system in terms of two elementary design principles: (1) there exists an optimal integration time, which is determined by the input statistics and the number of receptors; and (2) in the optimally designed system, the number of independent concentration measurements as set by the number of receptors and the optimal integration time equals the number of readout molecules that store these measurements and equals the work to store these measurements reliably; no resource is then in excess and hence wasted. Applying our theory to the
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.