Evidence map›Paper›PMID 33594973›Full record

ArticleeLife2021

Three-dimensional biofilm colony growth supports a mutualism involving matrix and nutrient sharing.

Heidi A Arjes, Lisa Willis, Haiwen Gui, Yangbo Xiao, Jason Peters, Carol Gross, Kerwyn Casey Huang

Open access · goldAbstract read
In one paragraph

Article in eLife, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed, 1 pooled it
1.4field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 1 synthesis or guideline pooled it, 23 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Article
  4. Mechanics limits ecological diversity and promotes heterogeneity in confined bacterial communities.Proceedings of the National Academy of Sciences of the United States of America · 2024
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 1 country.

Heidi A ArjesDepartment of Bioengineering, Stanford University School of Medicine, Stanford, United States.ORCID 0000-0002-4708-4286
Lisa WillisDepartment of Bioengineering, Stanford University School of Medicine, Stanford, United States.
Haiwen GuiDepartment of Bioengineering, Stanford University School of Medicine, Stanford, United States.ORCID 0000-0003-0564-940X
Yangbo XiaoDepartment of Bioengineering, Stanford University School of Medicine, Stanford, United States.
Jason PetersDepartment of Cell and Tissue Biology, University of California San Francisco, San Francisco, United States.
Carol GrossDepartment of Cell and Tissue Biology, University of California San Francisco, San Francisco, United States.ORCID 0000-0002-5595-9732
Kerwyn Casey HuangDepartment of Bioengineering, Stanford University School of Medicine, Stanford, United States.ORCID 0000-0002-8043-8138
Stanford University · USChan Zuckerberg Initiative (United States) · USUniversity of California, San Francisco · USUniversity of Wisconsin–Madison · US

Funding

Cellular homeostasis pathways in bacteriaR35GM118061 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI GROSS, CAROL ANNE · 2016 to 2025
$9.0M
CRISPR-based Functional Genomics in Pathogenic BacteriaK22AI137122 · NIAID · UNIVERSITY OF WISCONSIN-MADISON · PI PETERS, JASON M. · 2018 to 2019
$269k
NIAID NIH HHS K22 AI137122NIGMS NIH HHS R35 GM118061
6 · The paper itself

Abstract

Life in a three-dimensional biofilm is typical for many bacteria, yet little is known about how strains interact in this context. Here, we created essential gene CRISPR interference knockdown libraries in biofilm-forming

Indexed as

SymbiosisAlanine RacemaseBacillus subtilisBiofilmsClustered Regularly Interspaced Short Palindromic RepeatsCulture MediaGene Expression Regulation, BacterialGene Knockdown TechniquesAlanine RacemaseCulture MediaAlrAB. subtilisCRISPRiD-alanineecologyessential genesextracellular matrixinfectious diseasemicrobiologysurface growth

Identifiers

PMID33594973
PMCPMC7925131
OpenAlexW3133093240

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.