Evidence map›Paper›PMID 33594617›Full record

ArticleSleep & breathing = Schlaf & Atmung2021

Proof of principle study: diagnostic accuracy of a novel algorithm for the estimation of sleep stages and disease severity in patients with sleep-disordered breathing based on actigraphy and respiratory inductance plethysmography.

Sarah Dietz-Terjung, Amelie Ricarda Martin, Eysteinn Finnsson, Jón Skínir Ágústsson, Snorri Helgason, Halla Helgadóttir, Matthias Welsner, Christian Taube, Gerhard Weinreich, Christoph Schöbel

Registry-linked trialOpen access · hybridAbstract read
In one paragraph

Article in Sleep & breathing = Schlaf & Atmung, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07345312 (The Use of the BodySleep Algorithm), which is not on this map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.4field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07345312 recruitingnot on this mapstarted 2026, after this paper: background citation

The Use of the BodySleep Algorithm (ResMed) for the Diagnosis of Obstructive Sleep Apnea Syndrome in Children

TypeobservationalSponsorCentral Hospital, Nancy, FranceRan2026 to 2026Enrolled90ConditionsObstructive Sleep Apnea of ChildArmsPolysomnography
3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 15 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Sarah Dietz-TerjungFaculty of Sleep Medicine and Telemedicine, University Medicine Essen - Ruhrlandklinik, West German Lung Center, University Duisburg-Essen, Duisburg, Germany. sarah.terjung@rlk.uk-essen.de.ORCID 0000-0001-7907-6670
Amelie Ricarda MartinFaculty of Sleep Medicine and Telemedicine, University Medicine Essen - Ruhrlandklinik, West German Lung Center, University Duisburg-Essen, Duisburg, Germany.
Eysteinn FinnssonNox Research, Nox Medical ehf, Reykjavík, Iceland.
Jón Skínir ÁgústssonNox Research, Nox Medical ehf, Reykjavík, Iceland.
Snorri HelgasonNox Research, Nox Medical ehf, Reykjavík, Iceland.
Halla HelgadóttirNox Research, Nox Medical ehf, Reykjavík, Iceland.
Matthias WelsnerDepartment of Pulmonology, University Medicine Essen - Ruhrlandklinik, West German Lung Center, University Duisburg-Essen, Duisburg, Germany.
Christian TaubeDepartment of Pulmonology, University Medicine Essen - Ruhrlandklinik, West German Lung Center, University Duisburg-Essen, Duisburg, Germany.
Gerhard WeinreichDepartment of Pulmonology, University Medicine Essen - Ruhrlandklinik, West German Lung Center, University Duisburg-Essen, Duisburg, Germany.
Christoph SchöbelFaculty of Sleep Medicine and Telemedicine, University Medicine Essen - Ruhrlandklinik, West German Lung Center, University Duisburg-Essen, Duisburg, Germany.
Ruhrlandklinik · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeIn this proof of principle study, we evaluated the diagnostic accuracy of the novel Nox BodySleep

methodsPatients received PSG according to AASM. Sleep stages were manually scored using the AASM criteria and the recording was evaluated by the novel algorithm. The results were analyzed by descriptive statistics methods (IBM SPSS Statistics 25.0).

resultsWe found a strong Pearson correlation (r=0.91) with a bias of 0.2/h for AHI estimation as well as a good correlation (r=0.81) and an overestimation of 14 min for total sleep time (TST). Sleep efficiency (SE) was also valued with a good Pearson correlation (r=0.73) and an overestimation of 2.1%. Wake epochs were estimated with a sensitivity of 0.65 and a specificity of 0.59 while REM and non-REM (NREM) phases were evaluated a sensitivity of 0.72 and 0.74, respectively. Specificity was 0.74 for NREM and 0.68 for REM. Additionally, a Cohen's kappa of 0.62 was found for this 3-class classification problem.

conclusionThe algorithm shows a moderate diagnostic accuracy for the estimation of sleep. In addition, the algorithm determines the AHI with good agreement with the manual scoring and it shows good diagnostic accuracy in estimating wake-sleep transition. The presented algorithm seems to be an appropriate tool to increase the diagnostic accuracy of portable monitoring. The validated diagnostic algorithm promises a more appropriate and cost-effective method if integrated in out-of-center (OOC) testing of patients with suspicion for SDB.

Indexed as

AlgorithmsSeverity of Illness IndexSleep StagesActigraphyAdolescentAdultAgedAged, 80 and overFemaleHumansMaleMiddle AgedNeural Networks, ComputerPlethysmographyPolysomnographyProof of Concept StudyActigraphyArtificial intelligenceRecurrent neural networkRIPSleep stage estimation

Identifiers

PMID33594617
PMCPMC8590674
OpenAlexW3129412430

What OpenQuestion holds

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LicenceCC BY
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.