Evidence map›Paper›PMID 33594594›Full record

ReviewPain and therapy2021

Food for Special Medical Purposes and Nutraceuticals for Pain: A Narrative Review.

Roberto Casale, Zaira Symeonidou, Sofia Ferfeli, Fabrizio Micheli, Paolo Scarsella, Antonella Paladini

Erratum issuedOpen access · goldAbstract readReview
In one paragraph

Review in Pain and therapy, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 18 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed, 1 pooled it
2.3field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 1 synthesis or guideline pooled it, 27 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Review
  4. Vitamin abnormalities in neuropathic corneal pain.Eye and vision (London, England) · 2025
    Review
  5. Review
  6. Article
  7. Review
  8. Article
  9. Review
  10. Evaluation of the Probiotic Properties ofFood technology and biotechnology · 2023
    Article
  11. Review
  12. Review
  13. Review
  14. Review
  15. Review
  16. Review
  17. Article
  18. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors at 5 institutions in 3 countries.

Roberto CasaleOpusmedica Persons, Care and Research, NPO, 29121, Piacenza, Italy. robertocasale@opusmedica.org.ORCID http://orcid.org/0000-0002-5511-6831
Zaira SymeonidouOpusmedica Persons, Care and Research, NPO, 29121, Piacenza, Italy.
Sofia FerfeliDepartment of Physical and Rehabilitation Medicine, Hospice for Neurodisability, Athens, Greece.
Fabrizio MicheliPain Unit, Guglielmo da Saliceto General Hospital, 29121, Piacenza, Italy.
Paolo ScarsellaUSL Toscana Centro, Multidisciplinary Pain Clinic, Piero Palagi Hospital, Florence, Italy.
Antonella PaladiniDepartment of Anaesthesia and Pain Medicine, MESVA, University of L'Aquila, L'Aquila, Italy.
Azienda Usl Toscana Centro · ITGuglielmo da Saliceto Hospital · ITHellenic Airforce General Hospital · GRTamedia (Switzerland) · CHUniversity of L'Aquila · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionThe present paper focuses on the possible contribution of food compounds to alleviate symptomatic pains. Chronic pain can more easily be linked to anticipatory signals such as thirst and hunger than it is to sensory perceptions as its chronicity makes it fall under the behavioural category rather than it does senses. In fact, pain often negatively affects one's normal feeding behavioural patterns, both directly and indirectly, as it is associated with pain or because of its prostrating effects. NUTRITIONAL COMPOUNDS FOR PAIN: Several nutraceuticals and Foods for Special Medical Purposes (FSMPs) are reported to have significant pain relief efficacy with multiple antioxidant and anti-inflammatory properties. Apart from the aforementioned properties, amino acids, fatty acids, trace elements and vitamins may have a role in the modulation of pain signals to and within the nervous system.

conclusionIn our opinion, this review could be of great interest to clinicians, as it offers a complementary perspective in the management of pain. Trials with well-defined patient and symptoms selection and a robust pharmacological design are pivotal points to let these promising compounds become better accepted by the medical community.

Indexed as

Amino acids (tryptophan; phenylalanine; carnitine)Fatty acids (resolvines; PEA)Food for medical purposesFood for painMagnesiumMetalloporphyrinsSeleniumVitamins

Identifiers

PMID33594594
PMCPMC8119521
OpenAlexW3129973838

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.