Evidence map›Paper›PMID 33594486›Full record

ArticleBulletin of mathematical biology2021

Stochastic Chlamydia Dynamics and Optimal Spread.

German Enciso, Christine Sütterlin, Ming Tan, Frederic Y M Wan

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Bulletin of mathematical biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.8field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 7 citations in OpenAlex.

  1. Infection and immunity · 2026
    Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

German EncisoDepartment of Mathematics, University of California Irvine, Irvine, USA. enciso@uci.edu.ORCID 0000-0001-8908-9539
Christine SütterlinDepartment of Developmental and Cell Biology, University of California Irvine, Irvine, USA.
Ming TanDepartment of Microbiology and Molecular Genetics, University of California Irvine, Irvine, USA.
Frederic Y M WanDepartment of Mathematics, University of California Irvine, Irvine, USA.
University of California, Irvine · US

Funding

The Regulation of gene expression in ChlamydiaR01AI044198 · NIAID · UNIVERSITY OF CALIFORNIA-IRVINE · PI TAN, MING · 1999 to 2021
$7.1M
Mechanism of RB-to-EB Conversion in ChlamydiaR01AI151212 · NIAID · UNIVERSITY OF CALIFORNIA-IRVINE · PI BOASSA, DANIELA, ENCISO, GERMAN ANDRES · 2020 to 2024
$3.5M
NIAID NIH HHS R01 AI044198NIAID NIH HHS R01 AI151212
6 · The paper itself

Abstract

Chlamydia trachomatis is an important bacterial pathogen that has an unusual developmental switch from a dividing form (reticulate body or RB) to an infectious form (elementary body or EB). RBs replicate by binary fission within an infected host cell, but there is a delay before RBs convert into EBs for spread to a new host cell. We developed stochastic optimal control models of the Chlamydia developmental cycle to examine factors that control the number of EBs produced. These factors included the probability and timing of conversion, and the duration of the developmental cycle before the host cell lyses. Our mathematical analysis shows that the observed delay in RB-to-EB conversion is important for maximizing EB production by the end of the intracellular infection.

Indexed as

Chlamydia InfectionsChlamydia trachomatisModels, BiologicalHost Microbial InteractionsHumansBirth and death processesChlamydiaInfectious diseaseOptimal controlStochastic optimization

Identifiers

PMID33594486
PMCPMC8504186
OpenAlexW3130503862

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.