Evidence map›Paper›PMID 33594373›Full record

ArticlemedRxiv : the preprint server for health sciences2021

Early introductions and community transmission of SARS-CoV-2 variant B.1.1.7 in the United States.

Tara Alpert, Anderson F Brito, Erica Lasek-Nesselquist, Jessica Rothman, Andrew L Valesano, Matthew J MacKay, Mary E Petrone, Mallery I Breban, Anne E Watkins, Chantal B F Vogels and 40 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in medRxiv : the preprint server for health sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

50 authors.

Tara AlpertDepartment of Epidemiology of Microbial Diseases, Yale School of Public Health, New Haven, CT 06510, USA.
Anderson F BritoDepartment of Epidemiology of Microbial Diseases, Yale School of Public Health, New Haven, CT 06510, USA.
Erica Lasek-NesselquistWadsworth Center, New York State Department of Health, Albany, NY 12208, USA.
Jessica RothmanDepartment of Epidemiology of Microbial Diseases, Yale School of Public Health, New Haven, CT 06510, USA.
Andrew L ValesanoDepartment of Internal Medicine, Department of Microbiology and Immunology, University of Michigan, Ann Arbor, MI 48109, USA.
Matthew J MacKayTempus Labs, Chicago, IL 60654, USA.
Mary E PetroneDepartment of Epidemiology of Microbial Diseases, Yale School of Public Health, New Haven, CT 06510, USA.
Mallery I BrebanDepartment of Epidemiology of Microbial Diseases, Yale School of Public Health, New Haven, CT 06510, USA.
Anne E WatkinsDepartment of Epidemiology of Microbial Diseases, Yale School of Public Health, New Haven, CT 06510, USA.
Chantal B F VogelsDepartment of Epidemiology of Microbial Diseases, Yale School of Public Health, New Haven, CT 06510, USA.
Chaney C KalinichDepartment of Epidemiology of Microbial Diseases, Yale School of Public Health, New Haven, CT 06510, USA.
Simon DellicourSpatial Epidemiology Lab (SpELL), Université Libre de Bruxelles, Bruxelles, Belgium.
Alexis RussellWadsworth Center, New York State Department of Health, Albany, NY 12208, USA.
John P KellyWadsworth Center, New York State Department of Health, Albany, NY 12208, USA.
Matthew ShudtWadsworth Center, New York State Department of Health, Albany, NY 12208, USA.
Jonathan PlitnickWadsworth Center, New York State Department of Health, Albany, NY 12208, USA.
Erasmus SchneiderWadsworth Center, New York State Department of Health, Albany, NY 12208, USA.
William J FitzsimmonsDepartment of Internal Medicine, Department of Microbiology and Immunology, University of Michigan, Ann Arbor, MI 48109, USA.
Gaurav KhullarTempus Labs, Chicago, IL 60654, USA.
Jessica MettiTempus Labs, Chicago, IL 60654, USA.
Joel T DudleyTempus Labs, Chicago, IL 60654, USA.
Megan NashTempus Labs, Chicago, IL 60654, USA.
Nike BeaubierTempus Labs, Chicago, IL 60654, USA.
Jianhui WangDepartment of Pathology, Yale University School of Medicine, New Haven, CT 06510, USA.
Chen LiuDepartment of Pathology, Yale University School of Medicine, New Haven, CT 06510, USA.
Pei HuiDepartment of Pathology, Yale University School of Medicine, New Haven, CT 06510, USA.
Anthony MuyombweConnecticut State Department of Public Health, Rocky Hill, CT 06067, USA.
Randy DowningConnecticut State Department of Public Health, Rocky Hill, CT 06067, USA.
Jafar RazeqConnecticut State Department of Public Health, Rocky Hill, CT 06067, USA.
Stephen M BartConnecticut State Department of Public Health, Rocky Hill, CT 06067, USA.
Ardath GrillsCenters for Disease Control and Prevention, Atlanta, GA 30329, USA.
Stephanie M MorrisonCenters for Disease Control and Prevention, Atlanta, GA 30329, USA.
Steven MurphyMurphy Medical Associates, Greenwich, CT 06830, USA.
Caleb NealMurphy Medical Associates, Greenwich, CT 06830, USA.
Eva LaszloMurphy Medical Associates, Greenwich, CT 06830, USA.
Hanna RennertDepartment of Pathology and Laboratory Medicine, New York Presbyterian Hospital-Weill Cornell Medicine, New York, NY 10021, USA.
Melissa CushingDepartment of Pathology and Laboratory Medicine, New York Presbyterian Hospital-Weill Cornell Medicine, New York, NY 10021, USA.
Lars WestbladeDepartment of Pathology and Laboratory Medicine, New York Presbyterian Hospital-Weill Cornell Medicine, New York, NY 10021, USA.
Priya VeluDepartment of Pathology and Laboratory Medicine, New York Presbyterian Hospital-Weill Cornell Medicine, New York, NY 10021, USA.
Arryn CraneyDepartment of Pathology and Laboratory Medicine, New York Presbyterian Hospital-Weill Cornell Medicine, New York, NY 10021, USA.
Kathy A FauntleroyDepartment of Pathology and Laboratory Medicine, New York Presbyterian Hospital-Weill Cornell Medicine, New York, NY 10021, USA.
David R PeaperDepartments of Laboratory Medicine and Medicine, Yale School of Medicine, New Haven, CT 06510, USA.
Marie L LandryDepartments of Laboratory Medicine and Medicine, Yale School of Medicine, New Haven, CT 06510, USA.
Peter W CookCenters for Disease Control and Prevention, Atlanta, GA 30329, USA.
Joseph R FauverDepartment of Epidemiology of Microbial Diseases, Yale School of Public Health, New Haven, CT 06510, USA.
Christopher E MasonTempus Labs, Chicago, IL 60654, USA.
Adam S LauringDepartment of Internal Medicine, Department of Microbiology and Immunology, University of Michigan, Ann Arbor, MI 48109, USA.
Kirsten St GeorgeWadsworth Center, New York State Department of Health, Albany, NY 12208, USA.
Duncan R MacCannellCenters for Disease Control and Prevention, Atlanta, GA 30329, USA.
Nathan D GrubaughDepartment of Epidemiology of Microbial Diseases, Yale School of Public Health, New Haven, CT 06510, USA.

Funding

Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9M
NRSA Training CoreTL1TR001864 · NCATS · YALE UNIVERSITY · PI CANTLEY, LLOYD G, EDELMAN, E. JENNIFER · 2016 to 2025
$9.9M
NCATS NIH HHS TL1 TR001864NCATS NIH HHS UL1 TR001863
6 · The paper itself

Abstract

The emergence and spread of SARS-CoV-2 lineage B.1.1.7, first detected in the United Kingdom, has become a global public health concern because of its increased transmissibility. Over 2500 COVID-19 cases associated with this variant have been detected in the US since December 2020, but the extent of establishment is relatively unknown. Using travel, genomic, and diagnostic data, we highlight the primary ports of entry for B.1.1.7 in the US and locations of possible underreporting of B.1.1.7 cases. Furthermore, we found evidence for many independent B.1.1.7 establishments starting in early December 2020, followed by interstate spread by the end of the month. Finally, we project that B.1.1.7 will be the dominant lineage in many states by mid to late March. Thus, genomic surveillance for B.1.1.7 and other variants urgently needs to be enhanced to better inform the public health response.

Identifiers

PMID33594373
PMCPMC7885932

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.