Evidence map›Paper›PMID 33594370›Full record

ArticlebioRxiv : the preprint server for biology2021

Differential roles of RIG-I-like receptors in SARS-CoV-2 infection.

Duomeng Yang, Tingting Geng, Andrew G Harrison, Penghua Wang

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 29 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Duomeng YangDepartment of Immunology, School of Medicine, University of Connecticut Health Center, Farmington, CT 06030, USA.
Tingting GengDepartment of Immunology, School of Medicine, University of Connecticut Health Center, Farmington, CT 06030, USA.
Andrew G HarrisonDepartment of Immunology, School of Medicine, University of Connecticut Health Center, Farmington, CT 06030, USA.
Penghua WangDepartment of Immunology, School of Medicine, University of Connecticut Health Center, Farmington, CT 06030, USA.
UConn Health · US

Funding

The role of UBXNs in antiviral immunityR01AI132526 · NIAID · UNIVERSITY OF CONNECTICUT SCH OF MED/DNT · PI WANG, PENGHUA · 2018 to 2022
$2.1M
NIAID NIH HHS R01 AI132526
6 · The paper itself

Abstract

The retinoic acid-inducible gene I (RIG-I) and melanoma differentiation-associated protein 5 (MDA5) are the major viral RNA sensors that are essential for activation of antiviral immune responses. However, their roles in severe acute respiratory syndrome (SARS)-causing coronavirus (CoV) infection are largely unknown. Herein we investigate their functions in human epithelial cells, the primary and initial target of SARS-CoV-2, and the first line of host defense. A deficiency in MDA5 (

Identifiers

PMID33594370
PMCPMC7885922
OpenAlexW3126975932

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.