Evidence map›Paper›PMID 33594354›Full record

ArticleResearch square2021

A Human 3D neural assembloid model for SARS-CoV-2 infection.

Lu Wang, David Sievert, Joseph Gleeson, Alex E Clark, Aaron F Carlin, Hannah Federman, Benjamin D Gastfriend, Eric Shusta, Sean P Palecek

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in Research square, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 5 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 2 countries.

Lu WangDepartment of Neurosciences, University of California San Diego, La Jolla, CA, 92093, USA; Rady Children's Institute for Genomic Medicine, Rady Children's Hospital, San Diego, CA, 92123, USA.
David SievertDepartment of Neurosciences, University of California San Diego, La Jolla, CA, 92093, USA; Rady Children's Institute for Genomic Medicine, Rady Children's Hospital, San Diego, CA, 92123, USA.
Joseph GleesonDepartment of Neurosciences, University of California San Diego, La Jolla, CA, 92093, USA; Rady Children's Institute for Genomic Medicine, Rady Children's Hospital, San Diego, CA, 92123, USA; Department for Pediatrics, University of California San Diego, La Jolla, CA, 92093, USA.ORCID 0000-0002-0889-9220
Alex E ClarkDepartment of Medicine; University of California San Diego, School of Medicine, La Jolla, CA, 92093, USA.
Aaron F CarlinDepartment of Medicine; University of California San Diego, School of Medicine, La Jolla, CA, 92093, USA.ORCID 0000-0002-1669-8066
Hannah FedermanCenter for Immunity and Inflammation, New Jersey Medical School, Rutgers-The State University, Newark, NJ, 07103, USA.
Benjamin D GastfriendDepartment of Chemical and Biological Engineering, University of Wisconsin-Madison, Madison, WI, 53706, USA.
Eric ShustaDepartment of Chemical and Biological Engineering, University of Wisconsin-Madison, Madison, WI, 53706, USA.
Sean P PalecekDepartment of Chemical and Biological Engineering, University of Wisconsin-Madison, Madison, WI, 53706, USA.
University of California San Diego · USUniversity of Wisconsin–Madison · USRutgers Sexual and Reproductive Health and Rights · NL

Funding

BIOTECHNOLOGY TRAINING PROGRAMT32GM008349 · NIGMS · UNIVERSITY OF WISCONSIN-MADISON · PI FOX, BRIAN G · 1989 to 2019
$22.5M
U of Calif, San Diego Neuroscience Microscopy ImagingP30NS047101 · NINDS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI GLEESON, JOSEPH G, ZHENG, BINHAI · 2003 to 2022
$9.0M
Molecular basis of Zika-induced microcephalyR01NS106387 · NINDS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI GLEESON, JOSEPH G · 2018 to 2021
$2.2M
Investigating Pericyte Roles in Blood-Brain Barrier FormationR01NS103844 · NINDS · UNIVERSITY OF WISCONSIN-MADISON · PI SHUSTA, ERIC V · 2018 to 2022
$1.9M
Illumina NovaSeq 6000 Sequencing SystemS10OD026929 · OD · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI JEPSEN, KRISTEN LYNN · 2019 to 2019
$600k
NIGMS NIH HHS T32 GM008349NIH HHS S10 OD026929NINDS NIH HHS P30 NS047101NINDS NIH HHS R01 NS103844NINDS NIH HHS R01 NS106387
6 · The paper itself

Abstract

Clinical evidence suggests the central nervous system (CNS) is frequently impacted by SARS-CoV-2 infection, either directly or indirectly, although mechanisms remain unclear. Pericytes are perivascular cells within the brain that are proposed as SARS-CoV-2 infection points

Identifiers

PMID33594354
PMCPMC7885926
OpenAlexW3132412147

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.