ArticleCommunications biology2021
Intertissue small RNA communication mediates the acquisition and inheritance of hormesis in Caenorhabditis elegans.
Article in Communications biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 13 citations in OpenAlex.
- Transgenerational inheritance of altered H3K27me3 in wild-type Caenorhabditis elegans.The EMBO journal · 2026Article
- Soma-to-germline miRNA inheritance through yolk promotes stress resilience in progeny.Nature structural & molecular biology · 2026Article
- Adapting to an increasingly stressful environment: Experimental evidence for 'micro-evolutionary priming'.The Journal of animal ecology · 2025Article
- Parental Alcohol Exposures Associate with Lasting Mitochondrial Dysfunction and Accelerated Aging in a Mouse Model.Aging and disease · 2024Article
- Hypoxia induces transgenerational epigenetic inheritance of small RNAs.Cell reports · 2022Article
- Hormetic Effects of Carbendazim on Mycelial Growth and Aggressiveness ofJournal of fungi (Basel, Switzerland) · 2022Article
- The Intestine as a Lifespan- and Proteostasis-Promoting Signaling Tissue.Frontiers in aging · 2022Review
- Review
- Small RNAs in epigenetic inheritance: from mechanisms to trait transmission.FEBS letters · 2021Review
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Environmental conditions can cause phenotypic changes, part of which can be inherited by subsequent generations via soma-to-germline communication. However, the signaling molecules or pathways that mediate intertissue communication remain unclear. Here, we show that intertissue small RNA communication systems play a key role in the acquisition and inheritance of hormesis effects - stress-induced stress resistance - in Caenorhabditis elegans. The miRNA-processing enzyme DRSH-1 is involved in both the acquisition and the inheritance of hormesis, whereas worm-specific Argonaute (WAGO) proteins, which function with endo-siRNAs, are involved only in its inheritance. Further analyses demonstrate that the miRNA production system in the neuron and the small RNA transport machinery in the intestine are both essential for its acquisition and that both the transport of small RNAs in the germline and the germline Argonaute HRDE-1 complex are required for its inheritance. Our results thus demonstrate that overlapping and distinct roles of small RNA systems in the acquisition and inheritance of hormesis effects.
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Registered trials
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