ArticleScientific reports2021
Stellate cell computational modeling predicts signal filtering in the molecular layer circuit of cerebellum.
Article in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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15 citing papers in PubMed.
- Dendritic interaction of timescales in afterdepolarization potentials and nonmonotonic spike-adding.Journal of computational neuroscience · 2026Article
- A computational model of the cerebellar granular layer calibrated to experimental data for studying inhibition and sensory encoding.Scientific reports · 2025Article
- Cerebellar basket cell filtering of Purkinje cell responses elicited by low frequency parallel fibre transmission.Scientific reports · 2025Article
- Towards a quantum synapse for quantum sensing.Scientific reports · 2025Article
- Emerging biomimetic biopolymer-based composites: advancing accessible and sustainable neural disease models and therapeutics.Frontiers in bioengineering and biotechnology · 2025Review
- Human Purkinje cells outperform mouse Purkinje cells in dendritic complexity and computational capacity.Communications biology · 2024Article
- A multi-layer mean-field model of the cerebellum embedding microstructure and population-specific dynamics.PLoS computational biology · 2023Article
- Anisotropy and Frequency Dependence of Signal Propagation in the Cerebellar Circuit Revealed by High-Density Multielectrode Array Recordings.Biomedicines · 2023Article
- Model simulations unveil the structure-function-dynamics relationship of the cerebellar cortical microcircuit.Communications biology · 2022Article
- An overview of brain-like computing: Architecture, applications, and future trends.Frontiers in neurorobotics · 2022Review
- Computational models of neurotransmission at cerebellar synapses unveil the impact on network computation.Frontiers in computational neuroscience · 2022Review
- Cerebellar Circuits for Classical Fear Conditioning.Frontiers in cellular neuroscience · 2022Review
- Discovering Microcircuit Secrets With Multi-Spot Imaging and Electrophysiological Recordings: The Example of Cerebellar Network Dynamics.Frontiers in cellular neuroscience · 2022Review
- Modulation of the dynamics of cerebellar Purkinje cells through the interaction of excitatory and inhibitory feedforward pathways.PLoS computational biology · 2021Article
- The EBRAINS NeuroFeatureExtract: An Online Resource for the Extraction of Neural Activity Features From Electrophysiological Data.Frontiers in neuroinformatics · 2021Article
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7 authors.
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Abstract
The functional properties of cerebellar stellate cells and the way they regulate molecular layer activity are still unclear. We have measured stellate cells electroresponsiveness and their activation by parallel fiber bursts. Stellate cells showed intrinsic pacemaking, along with characteristic responses to depolarization and hyperpolarization, and showed a marked short-term facilitation during repetitive parallel fiber transmission. Spikes were emitted after a lag and only at high frequency, making stellate cells to operate as delay-high-pass filters. A detailed computational model summarizing these physiological properties allowed to explore different functional configurations of the parallel fiber-stellate cell-Purkinje cell circuit. Simulations showed that, following parallel fiber stimulation, Purkinje cells almost linearly increased their response with input frequency, but such an increase was inhibited by stellate cells, which leveled the Purkinje cell gain curve to its 4 Hz value. When reciprocal inhibitory connections between stellate cells were activated, the control of stellate cells over Purkinje cell discharge was maintained only at very high frequencies. These simulations thus predict a new role for stellate cells, which could endow the molecular layer with low-pass and band-pass filtering properties regulating Purkinje cell gain and, along with this, also burst delay and the burst-pause responses pattern.
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