ArticleScientific reports2021
Brain network motifs are markers of loss and recovery of consciousness.
Article in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed.
- Foundational issues of network models in biology.Biological cybernetics · 2026Review
- Neurons embedded in loop-like motifs act as central hubs for brain-wide integration.The Journal of physiology · 2026Article
- Distinct neurologic state in patients with traumatic brain injury and hemorrhagic stroke during the stage of acute disorders of consciousness and the correlation with the neurological prognosis: A multi-modal PET/rs-fMRI study.NeuroImage. Clinical · 2026Article
- From Chaos to Coherence: Effects of High-Order Synaptic Correlations on Neural Dynamics.ArXiv · 2025Article
- Typical and disrupted small-world architecture and regional communication in full-term and preterm infants.PNAS nexus · 2025Article
- The level of cognitive functioning in school-aged children is predicted by resting EEG Directed Phase Lag Index.Scientific reports · 2025Article
- The brain selectively allocates energy to functional brain networks under cognitive control.Scientific reports · 2024Article
- Stimulus type shapes the topology of cellular functional networks in mouse visual cortex.Nature communications · 2024Article
- Connecting the dots in the zona incerta: A study of neural assemblies and motifs of inter-area coordination in mice.iScience · 2024Article
- Cerebellar Purkinje cell firing promotes conscious recovery from anesthesia state through coordinating neuronal communications with motor cortex.Theranostics · 2024Article
- Abnormal and Changing Information Interaction in Adults with Attention-Deficit/Hyperactivity Disorder Based on Network Motifs.Brain sciences · 2023Article
- Latent sub-structural resilience mechanisms in temporal human mobility networks during urban flooding.Scientific reports · 2023Article
- A Real-Time Neurophysiologic Stress Test for the Aging Brain: Novel Perioperative and ICU Applications of EEG in Older Surgical Patients.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2023Review
- Disrupted multi-scale topological organization of directed functional brain networks in patients with disorders of consciousness.Brain communications · 2023Article
- Brain network motif topography may predict emergence from disorders of consciousness: a case series.Neuroscience of consciousness · 2020Article
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12 authors.
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Abstract
Motifs are patterns of inter-connections between nodes of a network, and have been investigated as building blocks of directed networks. This study explored the re-organization of 3-node motifs during loss and recovery of consciousness. Nine healthy subjects underwent a 3-h anesthetic protocol while 128-channel electroencephalography (EEG) was recorded. In the alpha (8-13 Hz) band, 5-min epochs of EEG were extracted for: Baseline; Induction; Unconscious; 30-, 10- and 5-min pre-recovery of responsiveness; 30- and 180-min post-recovery of responsiveness. We constructed a functional brain network using the weighted and directed phase lag index, on which we calculated the frequency and topology of 3-node motifs. Three motifs (motifs 1, 2 and 5) were significantly present across participants and epochs, when compared to random networks (p < 0.05). The topology of motifs 1 and 5 changed significantly between responsive and unresponsive epochs (p-values < 0.01; Kendall's W = 0.664 (motif 1) and 0.529 (motif 5)). Motif 1 was constituted of long-range chain-like connections, while motif 5 was constituted of short-range, loop-like connections. Our results suggest that anesthetic-induced unconsciousness is associated with a topological re-organization of network motifs. As motif topological re-organization may precede (motif 5) or accompany (motif 1) the return of responsiveness, motifs could contribute to the understanding of the neural correlates of consciousness.
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