ArticleScientific reports2021
Embossed topographic depolarisation maps of biological tissues with different morphological structures.
Article in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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14 citing papers in PubMed, 60 citations in OpenAlex.
- Depolarization diagrams for circularly polarized light scattering for biological particle monitoring.Journal of biomedical optics · 2024Article
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- Time-efficient filtering of imaging polarimetric data by checking physical realizability of experimental mueller matrices.Bioinformatics (Oxford, England) · 2024Article
- 3D polarization-interference holographic histology for wavelet-based differentiation of the polycrystalline component of biological tissues with different necrotic states. Forensic applications.Journal of biomedical optics · 2024Article
- MALDI IMS-Derived Molecular Contour Maps: Augmenting Histology Whole-Slide Images.Journal of the American Society for Mass Spectrometry · 2023Article
- Optical anisotropy composition of benign and malignant prostate tissues revealed by Mueller-matrix imaging.Biomedical optics express · 2022Article
- Recombinant Spidroin Microgel as the Base of Cell-Engineered Constructs Mediates Liver Regeneration in Rats.Polymers · 2022Article
- Toward the development of a polarimetric tool to diagnose the fibrotic human ventricular myocardium.Journal of biomedical optics · 2022Article
- Assessment of tissue pathology using optical polarimetry.Lasers in medical science · 2022Article
- Differentiation of Human GBM From Non-GBM Brain Tissue With Polarization Imaging Technique.Frontiers in oncology · 2022Article
- Polarimetric data-based model for tissue recognition.Biomedical optics express · 2021Article
- Polarization and depolarization metrics as optical markers in support to histopathology ofBiomedical optics express · 2021Article
- Toward a quantitative method for estimating tumour-stroma ratio in breast cancer using polarized light microscopy.Biomedical optics express · 2021Article
- 3D Mueller matrix mapping of layered distributions of depolarisation degree for analysis of prostate adenoma and carcinoma diffuse tissues.Scientific reports · 2021Article
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Authors and funding
10 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Layered topographic maps of the depolarisation due to diffuse biological tissues are produced using a polarisation-holographic Mueller matrix method approach. Histological sections of myocardial tissue with a spatially structured optically anisotropic fibrillar network, and parenchymal liver tissue with a polycrystalline island structure are successfully mapped. The topography of the myocardium maps relates to the scattering multiplicity within the volume and the specific morphological structures of the biological crystallite networks. The overall depolarisation map is a convolution of the effects of these two factors. Parenchymal liver tissues behave broadly similarly, but the different biological structures present cause the degree of scattering multiplicity to increase more rapidly with increasing phase. Through statistical analysis, the dependences of the magnitudes of the first to fourth order statistical moments are determined. These moments characterise the changing distributions of the depolarisation values through the volume of biological tissues with different morphological structures. Parenchymal liver tissue depolarisation maps are characterised by larger mean and variance, and less skewness and kurtosis, compared to the distributions for the myocardium. This work demonstrates that a polarisation-holographic Mueller matrix method can be applied to the assessment of the 3D morphology of biological tissues, with applications in disease diagnosis.
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