Evidence map›Paper›PMID 33594095›Full record

ArticleScientific reports2021

ABCC6 deficiency promotes dyslipidemia and atherosclerosis.

Christopher Brampton, Viola Pomozi, Li-Hsieh Chen, Ailea Apana, Sara McCurdy, Janna Zoll, William A Boisvert, Gilles Lambert, Daniel Henrion, Simon Blanchard and 4 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed
4.3field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 36 citations in OpenAlex.

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  19. The Expression Level of ABCC6 Transporter in Colon Cancer Cells Correlates with the Activation of Different Intracellular Signaling Pathways.Pathophysiology : the official journal of the International Society for Pathophysiology · 2022
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 6 institutions in 2 countries.

Christopher BramptonDepartment of Cell and Molecular Biology, John A. Burns School of Medicine, University of Hawaii, 651 Ilalo St. BSB222E, Honolulu, HI, USA.
Viola PomoziDepartment of Cell and Molecular Biology, John A. Burns School of Medicine, University of Hawaii, 651 Ilalo St. BSB222E, Honolulu, HI, USA.
Li-Hsieh ChenDepartment of Cell and Molecular Biology, John A. Burns School of Medicine, University of Hawaii, 651 Ilalo St. BSB222E, Honolulu, HI, USA.
Ailea ApanaDepartment of Cell and Molecular Biology, John A. Burns School of Medicine, University of Hawaii, 651 Ilalo St. BSB222E, Honolulu, HI, USA.
Sara McCurdyDepartment of Medicine, John A. Burns School of Medicine, University of Hawaii, Honolulu, HI, USA.
Janna ZollDepartment of Cell and Molecular Biology, John A. Burns School of Medicine, University of Hawaii, 651 Ilalo St. BSB222E, Honolulu, HI, USA.
William A BoisvertDepartment of Medicine, John A. Burns School of Medicine, University of Hawaii, Honolulu, HI, USA.
Gilles LambertUniversity of La Réunion Medical School (France) INSERM UMR1188 DéTROI, Ste Clotilde, La Réunion, France.
Daniel HenrionMITOVASC Institute - UMR CNRS 6015 INSERM U1083, University of Angers, Angers, France.
Simon BlanchardDépartement d'Immunologie et d'Allergologie, University Hospital of Angers, 49000, Angers, France.
Sheree KuoDepartment of Pediatrics Kapi'olani Medical Center for Women and Children, University of Hawaii, Honolulu, HI, USA.
Georges LeftheriotisFaculty of Medicine, University of Nice-Sophia Antipolis, 06107, Nice, France.
Ludovic MartinPXE Consultation Center, MAGEC Reference Center for Rare Skin Diseases, Angers University Hospital, Angers, France.
Olivier Le SauxDepartment of Cell and Molecular Biology, John A. Burns School of Medicine, University of Hawaii, 651 Ilalo St. BSB222E, Honolulu, HI, USA. lesaux@hawaii.edu.
University of Hawaiʻi at Mānoa · USUniversité d'Angers · FRCentre National de la Recherche Scientifique · FRInserm · FRKapiolani Medical Center for Women and Children · USUniversité Côte d'Azur · FR

Funding

TRPA1 Physiology in Diabetes, Metabolic Syndrome, and MetabolismP20GM113134 · NIGMS · UNIVERSITY OF HAWAII AT MANOA · PI Tyler Ray · 2017 to 2026
$21.5M
RESEARCH DESIGN, BIOSTATISTICS AND RESEARCH ETHICS COREG12MD007601 · NIMHD · UNIVERSITY OF HAWAII AT MANOA · PI BERRY, MARLA J · 2012 to 2016
$13.0M
Blood Cells in Hemostasis and ThrombosisT32HL086344 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI GINSBERG, MARK HOWARD · 2008 to 2023
$4.4M
NHLBI NIH HHS T32 HL086344NIGMS NIH HHS P20 GM113134NIMHD NIH HHS G12 MD007601
6 · The paper itself

Abstract

ABCC6 deficiency promotes ectopic calcification; however, circumstantial evidence suggested that ABCC6 may also influence atherosclerosis. The present study addressed the role of ABCC6 in atherosclerosis using Ldlr

Indexed as

AnimalsAtherosclerosisATP-Binding Cassette, Sub-Family C ProteinsBile Acids and SaltsDyslipidemiasFemaleHumansMacrophagesMaleMiceMice, Inbred C57BLPseudoxanthoma ElasticumRetrospective StudiesABCC6 protein, humanAbcc6 protein, mouseATP-Binding Cassette, Sub-Family C ProteinsBile Acids and Salts

Identifiers

PMID33594095
PMCPMC7887252
OpenAlexW3132045658

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.