ArticleNature communications2021
microRNA-33 maintains adaptive thermogenesis via enhanced sympathetic nerve activity.
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Article in Nature communications, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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20citing papers in PubMed
4.7field-weighted citation impact, top 4% of its field
What it found
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Who cites it
20 citing papers in PubMed, 47 citations in OpenAlex.
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- TOX3 in hypothalamic POMC-lineage cells regulates energy balance via the PTEN-AKT signaling axis.Nature communications · 2026Article
- Critical Role of microRNA-33a/b in Cardiovascular and Metabolic Disease: Molecular Mechanisms and Therapeutic Perspectives.Journal of atherosclerosis and thrombosis · 2026Review
- The activation of catecholamine neurons in the rostral ventrolateral medulla drives ventricular remodeling after myocardial ischemia/reperfusion injury.Basic research in cardiology · 2025Article
- MicroRNA-33 inhibition ameliorates muscular dystrophy by enhancing skeletal muscle regeneration.EMBO molecular medicine · 2025Article
- Small Differences and Big Changes: The Many Variables of MicroRNA Expression and Function in the Brain.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Review
- miRNA and leptin signaling in metabolic diseases and at extreme environments.Pharmacology research & perspectives · 2024Review
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- Integration of selective sweeps across the sheep genome: understanding the relationship between production and adaptation traits.Genetics, selection, evolution : GSE · 2024Article
- microRNA-33 controls hunger signaling in hypothalamic AgRP neurons.Nature communications · 2024Article
- Time for micro-RNAs in steatotic liver disease: a case-control study.Frontiers in endocrinology · 2024Article
- Climate Adaptation and Drift Shape the Genomes of Two Eel-Goby Sister Species Endemic to Contrasting Latitude.Animals : an open access journal from MDPI · 2023Article
- Effect of High-Intensity Interval Training on Fatty Infiltration After Delayed Rotator Cuff Repair in a Mouse Model.Orthopaedic journal of sports medicine · 2023Article
- Brown Adipose Tissue-A Translational Perspective.Endocrine reviews · 2023Review
- Deregulated RNAs involved in sympathetic regulation of sepsis-induced acute lung injury based on whole transcriptome sequencing.BMC genomics · 2022Article
- MicroRNAs as Mediators of Adipose Thermogenesis and Potential Therapeutic Targets for Obesity.Biology · 2022Review
- MANF in POMC Neurons Promotes Brown Adipose Tissue Thermogenesis and Protects Against Diet-Induced Obesity.Diabetes · 2022Article
- Cardiac Cx43 Signaling Is Enhanced and TGF-β1/SMAD2/3 Suppressed in Response to Cold Acclimation and Modulated by Thyroid Status in Hairless SHRBiomedicines · 2022Article
- A Review of miRNAs as Biomarkers and Effect of Dietary Modulation in Obesity Associated Cognitive Decline and Neurodegenerative Disorders.Frontiers in molecular neuroscience · 2021Review
Corrections and comments
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Authors and funding
33 authors at 3 institutions in 2 countries.
Takahiro HorieDepartment of Cardiovascular Medicine, Graduate School of Medicine, Kyoto University, Kyoto, Japan. thorie@kuhp.kyoto-u.ac.jp.ORCID 0000-0002-6766-750X
Tetsushi NakaoDepartment of Cardiovascular Medicine, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
Yui MiyasakaDepartment of Cardiovascular Medicine, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
Tomohiro NishinoDepartment of Cardiovascular Medicine, Graduate School of Medicine, Kyoto University, Kyoto, Japan.ORCID 0000-0002-3593-7368
Shigenobu MatsumuraLaboratory of Physiological Functions of Food, Division of Food Science and Biotechnology, Graduate School of Agriculture, Kyoto University, Kyoto, Japan.ORCID 0000-0002-7149-1375
Fumiko NakazekiDepartment of Cardiovascular Medicine, Graduate School of Medicine, Kyoto University, Kyoto, Japan.ORCID 0000-0001-6280-5742
Yuya IdeDepartment of Cardiovascular Medicine, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
Masahiro KimuraDepartment of Cardiovascular Medicine, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
Shuhei TsujiDepartment of Cardiovascular Medicine, Graduate School of Medicine, Kyoto University, Kyoto, Japan.ORCID 0000-0002-6297-5642
Randolph Ruiz RodriguezDepartment of Cardiovascular Medicine, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
Toshimitsu WatanabeDepartment of Cardiovascular Medicine, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
Tomohiro YamasakiDepartment of Cardiovascular Medicine, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
Sijia XuDepartment of Cardiovascular Medicine, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
Chiharu OtaniDepartment of Cardiovascular Medicine, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
Sawa MiyagawaDepartment of Cardiovascular Medicine, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
Kazuki MatsushitaDepartment of Cardiovascular Medicine, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
Naoya SowaDepartment of Cardiovascular Medicine, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
Aoi OmoriDepartment of Cardiovascular Medicine, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
Jin TanakaLaboratory of Physiological Functions of Food, Division of Food Science and Biotechnology, Graduate School of Agriculture, Kyoto University, Kyoto, Japan.
Chika NishimuraDepartment of Biological Sciences, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
Masataka NishigaDepartment of Cardiovascular Medicine, Graduate School of Medicine, Kyoto University, Kyoto, Japan.ORCID 0000-0001-5676-7671
Yasuhide KuwabaraDepartment of Cardiovascular Medicine, Graduate School of Medicine, Kyoto University, Kyoto, Japan.ORCID 0000-0002-9493-9494
Osamu BabaDepartment of Cardiovascular Medicine, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
Shin WatanabeDepartment of Cardiovascular Medicine, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
Hitoo NishiDepartment of Cardiovascular Medicine, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
Yasuhiro NakashimaDepartment of Cardiovascular Medicine, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
Marina R PicciottoDepartment of Psychiatry and Interdepartmental Neuroscience Program, Yale University School of Medicine, New Haven, CT, USA.ORCID 0000-0002-4404-1280
Haruhisa InoueCenter for iPS Cell Research and Application (CiRA), Kyoto University, Kyoto, Japan.ORCID 0000-0003-4736-9537
Dai WatanabeDepartment of Biological Sciences, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
Kazuhiro NakamuraDepartment of Integrative Physiology, Nagoya University Graduate School of Medicine, Nagoya, Japan.ORCID 0000-0002-6095-8996
Tsutomu SasakiLaboratory of Nutrition Chemistry, Division of Food Science and Biotechnology, Graduate School of Agriculture, Kyoto University, Kyoto, Japan.ORCID 0000-0001-8041-1915
Takeshi KimuraDepartment of Cardiovascular Medicine, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
Koh OnoDepartment of Cardiovascular Medicine, Graduate School of Medicine, Kyoto University, Kyoto, Japan. kohono@kuhp.kyoto-u.ac.jp.ORCID 0000-0002-4163-980X
Kyoto University · JPNagoya University · JPYale University · US
Funding
Acetylcholine signaling allows cognitive processes in the brain to regulate physiological responses to the environment: the example of central control of opiate toleranceDP1DA050986 · NIDA · YALE UNIVERSITY · PI PICCIOTTO, MARINA R · 2019 to 2023
$5.9MNIDA NIH HHS DP1 DA050986
Abstract
Adaptive thermogenesis is essential for survival, and therefore is tightly regulated by a central neural circuit. Here, we show that microRNA (miR)-33 in the brain is indispensable for adaptive thermogenesis. Cold stress increases miR-33 levels in the hypothalamus and miR-33
Indexed as
Adipose Tissue, BrownAnimalsBody TemperatureBody WeightBrainCell LineCold TemperatureDiet, High-FatEndoplasmic Reticulum StressHumansIntegrasesMaleMiceMice, ObeseMicroRNAsOxygen ConsumptionCre recombinaseIntegrasesMicroRNAsMirn33 microRNA, mouseProtein SubunitsReceptors, GABA-A
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.