Evidence map›Paper›PMID 33594002›Full record

ArticlemSystems2021

Chaperone-Mediated Stress Sensing in Mycobacterium tuberculosis Enables Fast Activation and Sustained Response.

Satyajit D Rao, Pratik Datta, Maria Laura Gennaro, Oleg A Igoshin

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in mSystems, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
0.6field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 13 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. Epinephrine StimulatesInternational journal of molecular sciences · 2023
    Article
  5. Review
  6. SigE: A master regulator ofFrontiers in microbiology · 2023
    Review
  7. Review
  8. Commonalities ofFrontiers in immunology · 2022
    Article
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Satyajit D Rao *Department of Bioengineering and Center for Theoretical Biological Physics, Rice University, Houston, Texas, USA.ORCID https://orcid.org/0000-0003-3300-6380
Pratik Datta *Public Health Research Institute, New Jersey Medical School, Newark, New Jersey, USA.
Maria Laura GennaroPublic Health Research Institute, New Jersey Medical School, Newark, New Jersey, USA.ORCID https://orcid.org/0000-0003-4801-3567
Oleg A IgoshinDepartment of Bioengineering and Center for Theoretical Biological Physics, Rice University, Houston, Texas, USA igoshin@rice.edu.ORCID https://orcid.org/0000-0002-1449-4772
Center for Theoretical Biological Physics · USRutgers New Jersey Medical School · US

Funding

FISH-Flow platform for host-based tuberculosis diagnosticsR01AI104615 · NIAID · RBHS-NEW JERSEY MEDICAL SCHOOL · PI GENNARO, MARIA LAURA · 2013 to 2017
$5.5M
Statins as Adjunctive, Host-Directed Therapy for TBUH3AI122309 · NIAID · JOHNS HOPKINS UNIVERSITY · PI KARAKOUSIS, PETROS C · 2017 to 2019
$4.3M
Foam cells as drug targets in tuberculosisR01HL149450 · NHLBI · RBHS-NEW JERSEY MEDICAL SCHOOL · PI GENNARO, MARIA LAURA, KARAKOUSIS, PETROS C · 2019 to 2022
$3.9M
Feedback regulation and transcirptional coupling in bacterial stress-responseR01GM096189 · NIGMS · RICE UNIVERSITY · PI IGOSHIN, OLEG · 2010 to 2014
$1.3M
Statins as Adjunctive, Host-Directed Therapy for TBUH2AI122309 · NIAID · JOHNS HOPKINS UNIVERSITY · PI KARAKOUSIS, PETROS C · 2015 to 2016
$1.2M
NHLBI NIH HHS R01 HL149450NIAID NIH HHS R01 AI104615NIAID NIH HHS UH2 AI122309NIAID NIH HHS UH3 AI122309NIGMS NIH HHS R01 GM096189
6 · The paper itself

Abstract

Dynamical properties of gene regulatory networks are tuned to ensure bacterial survival. In mycobacteria, the MprAB-σ

Indexed as

chaperonesmathematical modelingMycobacterium tuberculosissigma factorsstress responsetwo-component regulatory systems

Identifiers

PMID33594002
PMCPMC8561658
OpenAlexW3129449909

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.