Evidence map›Paper›PMID 33593906›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2021

Dual-purpose isocyanides produced by

Nicholas Raffa, Tae Hyung Won, Andrew Sukowaty, Kathleen Candor, Chengsen Cui, Saayak Halder, Mingji Dai, Julio A Landero-Figueroa, Frank C Schroeder, Nancy P Keller

Abstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.

0numbers the graph read from it
0cells of the map it votes in
39citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

39 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Review
  6. Journal of fungi (Basel, Switzerland) · 2025
    Article
  7. Article
  8. Recent developments inMicrobiology and molecular biology reviews : MMBR · 2025
    Review
  9. Article
  10. Copper-chelating natural products.Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry · 2025
    Review
  11. The proteomic response ofmicroLife · 2025
    Article
  12. Article
  13. Metals at the Host-Fungal Pathogen Battleground.Annual review of microbiology · 2024
    Review
  14. Article
  15. Convergent evolution in toxin detection and resistance provides evidence for conserved bacterial-fungal interactions.Proceedings of the National Academy of Sciences of the United States of America · 2024
    Article
  16. Article
  17. A Timeline of Biosynthetic Gene Cluster Discovery inJournal of fungi (Basel, Switzerland) · 2024
    Article
  18. Article
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Nicholas RaffaDepartment of Medical Microbiology and Immunology, University of Wisconsin-Madison, Madison, WI 53706.ORCID 0000-0003-0112-5262
Tae Hyung WonBoyce Thompson Institute and Department of Chemistry and Chemical Biology, Cornell University, Ithaca, NY 14853.
Andrew SukowatyDepartment of Medical Microbiology and Immunology, University of Wisconsin-Madison, Madison, WI 53706.
Kathleen CandorAgilent Metallomics Center of the Americas, Department of Chemistry, University of Cincinnati College of Arts and Science, Cincinnati, OH 45221.ORCID 0000-0002-0168-4243
Chengsen CuiDepartment of Chemistry and Center for Cancer Research, Purdue University, West Lafayette, IN 47906.ORCID 0000-0002-6867-1826
Saayak HalderDepartment of Chemistry and Center for Cancer Research, Purdue University, West Lafayette, IN 47906.ORCID 0000-0002-0445-8903
Mingji DaiDepartment of Chemistry and Center for Cancer Research, Purdue University, West Lafayette, IN 47906.ORCID 0000-0001-7956-6426
Julio A Landero-FigueroaDepartment of Pharmacology and System Biology, University of Cincinnati College of Medicine, Cincinnati, OH 45267.
Frank C SchroederBoyce Thompson Institute and Department of Chemistry and Chemical Biology, Cornell University, Ithaca, NY 14853.ORCID 0000-0002-4420-0237
Nancy P KellerDepartment of Medical Microbiology and Immunology, University of Wisconsin-Madison, Madison, WI 53706; npkeller@wisc.edu.ORCID 0000-0002-4386-9473

Funding

BIOTECHNOLOGY TRAINING PROGRAMT32GM008349 · NIGMS · UNIVERSITY OF WISCONSIN-MADISON · PI FOX, BRIAN G · 1989 to 2019
$22.5M
Synthesis and Study of Medicinally Important MoleculesR35GM128570 · NIGMS · PURDUE UNIVERSITY · PI Mingji Dai · 2018 to 2026
$3.7M
Comprehensive analysis of NRPS-derived metabolomes of three Aspergillus speciesR01GM112739 · NIGMS · UNIVERSITY OF WISCONSIN-MADISON · PI KELLER, NANCY P · 2015 to 2023
$2.8M
NIGMS NIH HHS R01 GM112739NIGMS NIH HHS R35 GM128570NIGMS NIH HHS T32 GM008349
6 · The paper itself

Abstract

The maintenance of sufficient but nontoxic pools of metal micronutrients is accomplished through diverse homeostasis mechanisms in fungi. Siderophores play a well established role for iron homeostasis; however, no copper-binding analogs have been found in fungi. Here we demonstrate that, in

Indexed as

Anti-Infective AgentsAspergillus fumigatusAspergillus nidulansButadienesCopperCyanidesFungal ProteinsGene DeletionGene Expression Regulation, FungalLaccaseMicrobial Sensitivity TestsMultigene FamilyMutationPhenolsPigmentationSpores, FungalAnti-Infective AgentsButadienesCopperCyanidesFungal ProteinsLaccasePhenolsxantocillinaspergilluschalkophorecopperfungiisocyanide

Identifiers

PMID33593906
PMCPMC7923669

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.