Evidence map›Paper›PMID 33593905›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2021

Competitive binding of independent extension and retraction motors explains the quantitative dynamics of type IV pili.

Matthias D Koch, Chenyi Fei, Ned S Wingreen, Joshua W Shaevitz, Zemer Gitai

Open access · greenAbstract readVideo-Audio Media
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers.

0numbers the graph read from it
0cells of the map it votes in
43citing papers in PubMed
8.1field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

43 citing papers in PubMed, 67 citations in OpenAlex.

  1. Article
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  6. mBio · 2026
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  10. Separation ofmBio · 2025
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  14. Milestones in the development ofJournal of bacteriology · 2025
    Review
  15. Article
  16. Review
  17. Article
  18. Review
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  20. Type IV pili ofEcoSal Plus · 2024
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Matthias D KochLewis-Sigler Institute for Integrative Genomics, Princeton University, Princeton, NJ 08540.ORCID 0000-0003-4408-9900
Chenyi FeiLewis-Sigler Institute for Integrative Genomics, Princeton University, Princeton, NJ 08540.ORCID 0000-0002-8287-4347
Ned S WingreenLewis-Sigler Institute for Integrative Genomics, Princeton University, Princeton, NJ 08540.ORCID 0000-0001-7384-2821
Joshua W ShaevitzLewis-Sigler Institute for Integrative Genomics, Princeton University, Princeton, NJ 08540; shaevitz@princeton.edu zgitai@princeton.edu.ORCID 0000-0001-8809-4723
Zemer GitaiDepartment of Molecular Biology, Princeton University, Princeton, NJ 08540; shaevitz@princeton.edu zgitai@princeton.edu.
Princeton University · US

Funding

Thermally robust chemotaxis and thermotaxis in Escherichia coliR01GM082938 · NIGMS · PRINCETON UNIVERSITY · PI WINGREEN, NED S · 2008 to 2025
$5.5M
Mechano-microbiology: how physical forces control bacterial-host interactionsDP1AI124669 · NIAID · PRINCETON UNIVERSITY · PI GITAI, ZEMER · 2015 to 2019
$4.0M
The biophysical mechanism of pilus-based surface sensing in Pseudomonas aeruginosaR21AI121828 · NIAID · PRINCETON UNIVERSITY · PI SHAEVITZ, JOSHUA W · 2016 to 2017
$436k
NIAID NIH HHS DP1 AI124669NIAID NIH HHS R21 AI121828NIGMS NIH HHS R01 GM082938
6 · The paper itself

Abstract

Type IV pili (TFP) function through cycles of extension and retraction. The coordination of these cycles remains mysterious due to a lack of quantitative measurements of multiple features of TFP dynamics. Here, we fluorescently label TFP in the pathogen

Indexed as

Fimbriae, BacterialFimbriae ProteinsFluorescent DyesMaleimidesMicroscopy, FluorescenceModels, BiologicalMolecular Motor ProteinsPseudomonas aeruginosaStochastic ProcessesAlexa Fluor 488 C5-maleimideFimbriae ProteinsFluorescent DyesMaleimidesMolecular Motor Proteinscompetitive bindingmolecular motorpilus dynamicstype IV pili

Identifiers

PMID33593905
PMCPMC7923367
OpenAlexW3130855770

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.