Observational studyNeurology2021
Quantifying Treatment-Related Fluctuations in CIDP: Results of the GRIPPER Study.
Registry-linked trialOpen access · bronzeAbstract readObservational Study
In one paragraph
Observational study in Neurology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02414490 (Intravenous Immunoglobulin), which is not on this map. Cited by 12 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed, 1 pooled it
1.9field-weighted citation impact, top 12% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Intravenous Immunoglobulin (IVIg) Treatment-Related Fluctuations in Chronic Inflammatory Demyelinating Polyneuropathy (CIDP) Patients Using Daily Grip Strength Measurements (GRIPPER)
Who cites it
12 citing papers in PubMed, 1 synthesis or guideline pooled it, 23 citations in OpenAlex.
- Comparative efficacy, safety, and functional recovery of neonatal fc receptor inhibitors and conventional immunotherapies for chronic inflammatory demyelinating polyradiculoneuropathy: a systematic review and network meta-analysis.Frontiers in immunology · 2026Pooled it
- Assessing deterioration using impairment and functional outcome measures in chronic inflammatory demyelinating polyneuropathy: A post-hoc analysis of the immunoglobulin overtreatment in CIDP trial.Journal of the peripheral nervous system : JPNS · 2022Trial
- Consensus Definitions of Disease Activity and Clinical Outcomes in Patients With Chronic Inflammatory Demyelinating Polyradiculoneuropathy.Neurology · 2026Article
- Minimal Clinically Important Differences in Measuring Treatment Effects in CIDP: History, Current Use, Limitations, and Prospects.Muscle & nerve · 2025Review
- Minimal Clinically Important Difference for the Jamar Hand Grip Dynamometer in CIDP: A Korea-UK Study.European journal of neurology · 2025Article
- Feasibility and Reliability of a Monitoring App for Chronic Inflammatory Neuropathies.Journal of the peripheral nervous system : JPNS · 2025Article
- Review
- Serum neurofilament light chain does not detect self-reported treatment-related fluctuations in chronic inflammatory demyelinating polyneuropathy.European journal of neurology · 2024Article
- Introducing electronic monitoring of disease activity in patients with chronic inflammatory demyelinating polyneuropathy (EMDA CIDP): trial protocol of a proof of concept study.Neurological research and practice · 2023Article
- CIDP prognosis in patients with IVIG treatment-related fluctuations.Muscle & nerve · 2023Observational
- Assessment timing and choice of outcome measure in determining treatment response in chronic inflammatory demyelinating polyneuropathy: A post hoc analysis of the PRISM trial.Muscle & nerve · 2022Article
- Real-world outcomes after switching from standard therapy to efgartigimod in five patients with chronic inflammatory demyelinating polyradiculoneuropathy: a case series study in Japan.Frontiers in neurologyArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors at 1 institution in 1 country.
Jeffrey A AllenFrom the Department of Neurology (J.A.A.), and School of Public Heath (M.B.F.), Division of Biostatistics, University of Minnesota, Minneapolis; Department of Neurology (M.P., M.M.D.), University of Kansas Medical Center, Kansas City; Department of Neurology (S.A.-D.), Northwestern University, Chicago, IL; Department of Neurology (T.H.B.), Columbia University Medical Center, New York, NY; Neurology at Johns Creek (A.A.C.), LLC, Atlanta, GA; BriovaRx (T.W.), Lenexa, KS; Department of Neurology (J.T.K.), Ohio State University, Columbus; Department of Neurology (I.M.), Maastricht University Medical Centre+; Curaçao Medical Center (I.M.), Willemstad, the Netherlands; Department of Neurology (K.C.G.), St. Elizabeth's Medical Center, Tufts University School of Medicine, Boston, MA; and Department of Neurology (R.A.L.), Cedars-Sinai Medical Center, Los Angeles, CA. jaallen@umn.edu.
Mamatha PasnoorFrom the Department of Neurology (J.A.A.), and School of Public Heath (M.B.F.), Division of Biostatistics, University of Minnesota, Minneapolis; Department of Neurology (M.P., M.M.D.), University of Kansas Medical Center, Kansas City; Department of Neurology (S.A.-D.), Northwestern University, Chicago, IL; Department of Neurology (T.H.B.), Columbia University Medical Center, New York, NY; Neurology at Johns Creek (A.A.C.), LLC, Atlanta, GA; BriovaRx (T.W.), Lenexa, KS; Department of Neurology (J.T.K.), Ohio State University, Columbus; Department of Neurology (I.M.), Maastricht University Medical Centre+; Curaçao Medical Center (I.M.), Willemstad, the Netherlands; Department of Neurology (K.C.G.), St. Elizabeth's Medical Center, Tufts University School of Medicine, Boston, MA; and Department of Neurology (R.A.L.), Cedars-Sinai Medical Center, Los Angeles, CA.
Mazen M DimachkieFrom the Department of Neurology (J.A.A.), and School of Public Heath (M.B.F.), Division of Biostatistics, University of Minnesota, Minneapolis; Department of Neurology (M.P., M.M.D.), University of Kansas Medical Center, Kansas City; Department of Neurology (S.A.-D.), Northwestern University, Chicago, IL; Department of Neurology (T.H.B.), Columbia University Medical Center, New York, NY; Neurology at Johns Creek (A.A.C.), LLC, Atlanta, GA; BriovaRx (T.W.), Lenexa, KS; Department of Neurology (J.T.K.), Ohio State University, Columbus; Department of Neurology (I.M.), Maastricht University Medical Centre+; Curaçao Medical Center (I.M.), Willemstad, the Netherlands; Department of Neurology (K.C.G.), St. Elizabeth's Medical Center, Tufts University School of Medicine, Boston, MA; and Department of Neurology (R.A.L.), Cedars-Sinai Medical Center, Los Angeles, CA.ORCID 0000-0002-7148-989X
Senda Ajroud-DrissFrom the Department of Neurology (J.A.A.), and School of Public Heath (M.B.F.), Division of Biostatistics, University of Minnesota, Minneapolis; Department of Neurology (M.P., M.M.D.), University of Kansas Medical Center, Kansas City; Department of Neurology (S.A.-D.), Northwestern University, Chicago, IL; Department of Neurology (T.H.B.), Columbia University Medical Center, New York, NY; Neurology at Johns Creek (A.A.C.), LLC, Atlanta, GA; BriovaRx (T.W.), Lenexa, KS; Department of Neurology (J.T.K.), Ohio State University, Columbus; Department of Neurology (I.M.), Maastricht University Medical Centre+; Curaçao Medical Center (I.M.), Willemstad, the Netherlands; Department of Neurology (K.C.G.), St. Elizabeth's Medical Center, Tufts University School of Medicine, Boston, MA; and Department of Neurology (R.A.L.), Cedars-Sinai Medical Center, Los Angeles, CA.
Thomas H BrannaganFrom the Department of Neurology (J.A.A.), and School of Public Heath (M.B.F.), Division of Biostatistics, University of Minnesota, Minneapolis; Department of Neurology (M.P., M.M.D.), University of Kansas Medical Center, Kansas City; Department of Neurology (S.A.-D.), Northwestern University, Chicago, IL; Department of Neurology (T.H.B.), Columbia University Medical Center, New York, NY; Neurology at Johns Creek (A.A.C.), LLC, Atlanta, GA; BriovaRx (T.W.), Lenexa, KS; Department of Neurology (J.T.K.), Ohio State University, Columbus; Department of Neurology (I.M.), Maastricht University Medical Centre+; Curaçao Medical Center (I.M.), Willemstad, the Netherlands; Department of Neurology (K.C.G.), St. Elizabeth's Medical Center, Tufts University School of Medicine, Boston, MA; and Department of Neurology (R.A.L.), Cedars-Sinai Medical Center, Los Angeles, CA.
Albert A CookFrom the Department of Neurology (J.A.A.), and School of Public Heath (M.B.F.), Division of Biostatistics, University of Minnesota, Minneapolis; Department of Neurology (M.P., M.M.D.), University of Kansas Medical Center, Kansas City; Department of Neurology (S.A.-D.), Northwestern University, Chicago, IL; Department of Neurology (T.H.B.), Columbia University Medical Center, New York, NY; Neurology at Johns Creek (A.A.C.), LLC, Atlanta, GA; BriovaRx (T.W.), Lenexa, KS; Department of Neurology (J.T.K.), Ohio State University, Columbus; Department of Neurology (I.M.), Maastricht University Medical Centre+; Curaçao Medical Center (I.M.), Willemstad, the Netherlands; Department of Neurology (K.C.G.), St. Elizabeth's Medical Center, Tufts University School of Medicine, Boston, MA; and Department of Neurology (R.A.L.), Cedars-Sinai Medical Center, Los Angeles, CA.
Timothy WaltonFrom the Department of Neurology (J.A.A.), and School of Public Heath (M.B.F.), Division of Biostatistics, University of Minnesota, Minneapolis; Department of Neurology (M.P., M.M.D.), University of Kansas Medical Center, Kansas City; Department of Neurology (S.A.-D.), Northwestern University, Chicago, IL; Department of Neurology (T.H.B.), Columbia University Medical Center, New York, NY; Neurology at Johns Creek (A.A.C.), LLC, Atlanta, GA; BriovaRx (T.W.), Lenexa, KS; Department of Neurology (J.T.K.), Ohio State University, Columbus; Department of Neurology (I.M.), Maastricht University Medical Centre+; Curaçao Medical Center (I.M.), Willemstad, the Netherlands; Department of Neurology (K.C.G.), St. Elizabeth's Medical Center, Tufts University School of Medicine, Boston, MA; and Department of Neurology (R.A.L.), Cedars-Sinai Medical Center, Los Angeles, CA.
Mark B FiecasFrom the Department of Neurology (J.A.A.), and School of Public Heath (M.B.F.), Division of Biostatistics, University of Minnesota, Minneapolis; Department of Neurology (M.P., M.M.D.), University of Kansas Medical Center, Kansas City; Department of Neurology (S.A.-D.), Northwestern University, Chicago, IL; Department of Neurology (T.H.B.), Columbia University Medical Center, New York, NY; Neurology at Johns Creek (A.A.C.), LLC, Atlanta, GA; BriovaRx (T.W.), Lenexa, KS; Department of Neurology (J.T.K.), Ohio State University, Columbus; Department of Neurology (I.M.), Maastricht University Medical Centre+; Curaçao Medical Center (I.M.), Willemstad, the Netherlands; Department of Neurology (K.C.G.), St. Elizabeth's Medical Center, Tufts University School of Medicine, Boston, MA; and Department of Neurology (R.A.L.), Cedars-Sinai Medical Center, Los Angeles, CA.
John T KisselFrom the Department of Neurology (J.A.A.), and School of Public Heath (M.B.F.), Division of Biostatistics, University of Minnesota, Minneapolis; Department of Neurology (M.P., M.M.D.), University of Kansas Medical Center, Kansas City; Department of Neurology (S.A.-D.), Northwestern University, Chicago, IL; Department of Neurology (T.H.B.), Columbia University Medical Center, New York, NY; Neurology at Johns Creek (A.A.C.), LLC, Atlanta, GA; BriovaRx (T.W.), Lenexa, KS; Department of Neurology (J.T.K.), Ohio State University, Columbus; Department of Neurology (I.M.), Maastricht University Medical Centre+; Curaçao Medical Center (I.M.), Willemstad, the Netherlands; Department of Neurology (K.C.G.), St. Elizabeth's Medical Center, Tufts University School of Medicine, Boston, MA; and Department of Neurology (R.A.L.), Cedars-Sinai Medical Center, Los Angeles, CA.
Ingemar MerkiesFrom the Department of Neurology (J.A.A.), and School of Public Heath (M.B.F.), Division of Biostatistics, University of Minnesota, Minneapolis; Department of Neurology (M.P., M.M.D.), University of Kansas Medical Center, Kansas City; Department of Neurology (S.A.-D.), Northwestern University, Chicago, IL; Department of Neurology (T.H.B.), Columbia University Medical Center, New York, NY; Neurology at Johns Creek (A.A.C.), LLC, Atlanta, GA; BriovaRx (T.W.), Lenexa, KS; Department of Neurology (J.T.K.), Ohio State University, Columbus; Department of Neurology (I.M.), Maastricht University Medical Centre+; Curaçao Medical Center (I.M.), Willemstad, the Netherlands; Department of Neurology (K.C.G.), St. Elizabeth's Medical Center, Tufts University School of Medicine, Boston, MA; and Department of Neurology (R.A.L.), Cedars-Sinai Medical Center, Los Angeles, CA.
Kenneth C GorsonFrom the Department of Neurology (J.A.A.), and School of Public Heath (M.B.F.), Division of Biostatistics, University of Minnesota, Minneapolis; Department of Neurology (M.P., M.M.D.), University of Kansas Medical Center, Kansas City; Department of Neurology (S.A.-D.), Northwestern University, Chicago, IL; Department of Neurology (T.H.B.), Columbia University Medical Center, New York, NY; Neurology at Johns Creek (A.A.C.), LLC, Atlanta, GA; BriovaRx (T.W.), Lenexa, KS; Department of Neurology (J.T.K.), Ohio State University, Columbus; Department of Neurology (I.M.), Maastricht University Medical Centre+; Curaçao Medical Center (I.M.), Willemstad, the Netherlands; Department of Neurology (K.C.G.), St. Elizabeth's Medical Center, Tufts University School of Medicine, Boston, MA; and Department of Neurology (R.A.L.), Cedars-Sinai Medical Center, Los Angeles, CA.
Richard A LewisFrom the Department of Neurology (J.A.A.), and School of Public Heath (M.B.F.), Division of Biostatistics, University of Minnesota, Minneapolis; Department of Neurology (M.P., M.M.D.), University of Kansas Medical Center, Kansas City; Department of Neurology (S.A.-D.), Northwestern University, Chicago, IL; Department of Neurology (T.H.B.), Columbia University Medical Center, New York, NY; Neurology at Johns Creek (A.A.C.), LLC, Atlanta, GA; BriovaRx (T.W.), Lenexa, KS; Department of Neurology (J.T.K.), Ohio State University, Columbus; Department of Neurology (I.M.), Maastricht University Medical Centre+; Curaçao Medical Center (I.M.), Willemstad, the Netherlands; Department of Neurology (K.C.G.), St. Elizabeth's Medical Center, Tufts University School of Medicine, Boston, MA; and Department of Neurology (R.A.L.), Cedars-Sinai Medical Center, Los Angeles, CA.
University of Kansas Medical Center · US
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveThe objective of this study was to explore the extent of IV immunoglobulin (IVIG) treatment-related fluctuations (TRFs) by using home collection of daily grip strength in patients with chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) and to use that information to develop evidence-based treatment optimization strategies.
methodsThis prospective observational study included 25 patients with well-defined CIDP. Participants recorded grip strength daily for 6 months. Disability and gait metrics were collected weekly. Serum immunoglobulin G levels were obtained at peak, trough, and midcycle IVIG intervals. Day-to-day grip strength changes <10% were considered random. To identify patients with TRFs, 3-day averaged grip strength was calculated on each consecutive day after an IVIG infusion. TRFs were defined as ≥10% 3-day averaged grip strength difference compared to the pre-IVIG baseline.
resultsParticipants successfully recorded grip strength on all but 9% of recordable days. Twelve patients (48%) were classified as low/no fluctuaters and 13 (52%) as frequent fluctuaters. In the frequent fluctuating group, grip strength improved over 1 week and thereafter was relatively stable until the third week after infusion. Grip strength was significantly correlated with measures of disability.
conclusionsGrip strength collection by patients at home is reliable, valid, and feasible. A change in grip strength by ≥10% is a useful, practical, and evidence-based approach that may be used to identify clinically meaningful TRFs. From these data, we propose a treatment optimization strategy for patients with CIDP on chronic IVIG that may be applied to routine clinic care during both face-to-face and virtual video or telephone patient encounters. TRIAL REGISTRATION INFORMATION: ClinicalTrials.gov Identifier: NCT02414490.
Indexed as
Disability EvaluationPatient Reported Outcome MeasuresRecovery of FunctionAdultAgedFemaleHand StrengthHumansImmunoglobulins, IntravenousMaleMiddle AgedPolyradiculoneuropathy, Chronic Inflammatory DemyelinatingYoung AdultImmunoglobulins, Intravenous
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Registered trials
NCT02414490ClinicalTrials.gov
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.