Evidence map›Paper›PMID 33593858›Full record

ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2021

Rod Photoreceptors Avoid Saturation in Bright Light by the Movement of the G Protein Transducin.

Rikard Frederiksen, Ala Morshedian, Sonia A Tripathy, Tongzhou Xu, Gabriel H Travis, Gordon L Fain, Alapakkam P Sampath

Open access · bronzeAbstract read
In one paragraph

Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed
2.4field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

29 citing papers in PubMed, 42 citations in OpenAlex.

  1. E122Q rhodopsin: pigment microspectrophotometry, photoreceptor light responses, and bleaching adaptation.Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology · 2026
    Article
  2. Article
  3. Article
  4. The physiology of dark adaptation: Progress and future directions.Progress in retinal and eye research · 2025
    Review
  5. Article
  6. Article
  7. Advances and therapeutic opportunities in visual cycle modulation.Progress in retinal and eye research · 2025
    Review
  8. Review
  9. Review
  10. Article
  11. Light-sensitive CaProceedings of the National Academy of Sciences of the United States of America · 2024
    Article
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  15. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Rikard FrederiksenDepartment of Ophthalmology and Jules Stein Eye Institute, University of California, Los Angeles, California 90095-7000.
Ala MorshedianDepartment of Ophthalmology and Jules Stein Eye Institute, University of California, Los Angeles, California 90095-7000.
Sonia A TripathyDepartment of Ophthalmology and Jules Stein Eye Institute, University of California, Los Angeles, California 90095-7000.
Tongzhou XuDepartment of Ophthalmology and Jules Stein Eye Institute, University of California, Los Angeles, California 90095-7000.
Gabriel H TravisDepartment of Ophthalmology and Jules Stein Eye Institute, University of California, Los Angeles, California 90095-7000.
Gordon L FainDepartment of Ophthalmology and Jules Stein Eye Institute, University of California, Los Angeles, California 90095-7000 gfain@ucla.edu asampath@jsei.ucla.edu.ORCID 0000-0002-9813-0342
Alapakkam P SampathDepartment of Ophthalmology and Jules Stein Eye Institute, University of California, Los Angeles, California 90095-7000 gfain@ucla.edu asampath@jsei.ucla.edu.ORCID 0000-0002-0785-9577
University of California, Los Angeles · US

Funding

Vision Research Core at UCLAP30EY000331 · NEI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Xian-Jie Yang · 1985 to 2026
$16.8M
PHYSIOLOGY OF PHOTORECEPTORSR01EY001844 · NEI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI GORDON Lee FAIN · 1985 to 2026
$9.9M
Mechanisms for Light-driven Chromophore Synthesis by Müller Cells to Regenerate Cone Opsin and Maintain Cone SensitivityR01EY024379 · NEI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI TRAVIS, GABRIEL H · 2015 to 2024
$3.3M
Molecular Mechanisms of Photoreceptor AdaptationR01EY029817 · NEI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI SAMPATH, ALAPAKKAM P · 2019 to 2023
$2.1M
MOLECULAR GENETICS OF EARLY EYE DEVELOPMENTZ01EY000311 · NEI · NATIONAL EYE INSTITUTE · PI TOMAREV, STANISLAV I · 1996 to 2008
$941k
PHYSIOLOGY OF PHOTORECEPTORSR37EY001844 · NEI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI FAIN, GORDON LEE · 1990 to 1999
–
Intramural NIH HHS Z01 EY000311NEI NIH HHS P30 EY000331NEI NIH HHS R01 EY001844NEI NIH HHS R01 EY024379NEI NIH HHS R01 EY029817NEI NIH HHS R37 EY001844
6 · The paper itself

Abstract

Rod photoreceptors can be saturated by exposure to bright background light, so that no flash superimposed on the background can elicit a detectable response. This phenomenon, called increment saturation, was first demonstrated psychophysically by Aguilar and Stiles and has since been shown in many studies to occur in single rods. Recent experiments indicate, however, that rods may be able to avoid saturation under some conditions of illumination. We now show in

Indexed as

AnimalsElectroretinographyFemaleLightMaleMiceProtein TransportRetinal Rod Photoreceptor CellsSingle-Cell AnalysisTransducinVision, OcularTransducinadaptationG proteinretinarod photoreceptorsaturationvisual pigment

Identifiers

PMID33593858
PMCPMC8051685
OpenAlexW3133101565

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.