ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2021
Diversity of Receptive Fields and Sideband Inhibition with Complex Thalamocortical and Intracortical Origin in L2/3 of Mouse Primary Auditory Cortex.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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22 citing papers in PubMed.
- Optimization of spatial and temporal sampling resolution for optophysiology in large-scale two-photon calcium imaging.Biomedical optics express · 2026Article
- Layer 6 corticothalamic neurons show diverse and dynamic responses that support a role in cortical gain control in noisy environments.bioRxiv : the preprint server for biology · 2026Article
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- Precise Extraction of Neural Motifs Reveals Multiscale, Parallel Encoding Schemes in Auditory Cortex.bioRxiv : the preprint server for biology · 2025Article
- Rapid rebalancing of co-tuned ensemble activity in the auditory cortex.bioRxiv : the preprint server for biology · 2025Article
- Patchy harmonic functional connectivity of the mouse auditory cortex.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Limiting Hearing Loss in Transgenic Mouse Models.eNeuro · 2025Article
- Sparse representation of neurons for encoding complex sounds in the auditory cortex.Progress in neurobiology · 2024Article
- Auditory discrimination learning differentially modulates neural representation in auditory cortex subregions and inter-areal connectivity.Cell reports · 2024Article
- Learning within a sensory-motor circuit links action to expected outcome.bioRxiv : the preprint server for biology · 2024Article
- Orbitofrontal cortex conveys stimulus and task information to the auditory cortex.Current biology : CB · 2023Article
- Auditory cortex ensembles jointly encode sound and locomotion speed to support sound perception during movement.PLoS biology · 2023Article
- Pairing with Enriched Sound Exposure Restores Auditory Processing Degraded by an Antidepressant.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
- Distinct topographic organization and network activity patterns of corticocollicular neurons within layer 5 auditory cortex.Frontiers in neural circuits · 2023Article
- An inhibitory glycinergic projection from the cochlear nucleus to the lateral superior olive.Frontiers in neural circuits · 2023Article
- Surround suppression in mouse auditory cortex underlies auditory edge detection.PLoS computational biology · 2023Article
- Signal processing and stimulation potential within the ascending auditory pathway: a review.Frontiers in neuroscience · 2023Review
- Sensory regulation of absence seizures in a mouse model ofiScience · 2022Article
- Sequential transmission of task-relevant information in cortical neuronal networks.Cell reports · 2022Article
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Abstract
Receptive fields of primary auditory cortex (A1) neurons show excitatory neuronal frequency preference and diverse inhibitory sidebands. While the frequency preferences of excitatory neurons in local A1 areas can be heterogeneous, those of inhibitory neurons are more homogeneous. To date, the diversity and the origin of inhibitory sidebands in local neuronal populations and the relation between local cellular frequency preference and inhibitory sidebands are unknown. To reveal both excitatory and inhibitory subfields, we presented two-tone and pure tone stimuli while imaging excitatory neurons (Thy1) and two types of inhibitory neurons (parvalbumin and somatostatin) in L2/3 of mice A1. We classified neurons into six classes based on frequency response area (FRA) shapes and sideband inhibition depended both on FRA shapes and cell types. Sideband inhibition showed higher local heterogeneity than frequency tuning, suggesting that sideband inhibition originates from diverse sources of local and distant neurons. Two-tone interactions depended on neuron subclasses with excitatory neurons showing the most nonlinearity. Onset and offset neurons showed dissimilar spectral integration, suggesting differing circuits processing sound onset and offset. These results suggest that excitatory neurons integrate complex and nonuniform inhibitory input. Thalamocortical terminals also exhibited sideband inhibition, but with different properties from those of cortical neurons. Thus, some components of sideband inhibition are inherited from thalamocortical inputs and are further modified by converging intracortical circuits. The combined heterogeneity of frequency tuning and diverse sideband inhibition facilitates complex spectral shape encoding and allows for rapid and extensive plasticity.
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