Evidence map›Paper›PMID 33593383›Full record

ArticleMalaria journal2021

Reduced circulating dendritic cells in acute Plasmodium knowlesi and Plasmodium falciparum malaria despite elevated plasma Flt3 ligand levels.

Jessica R Loughland, Tonia Woodberry, Damian Oyong, Kim A Piera, Fiona H Amante, Bridget E Barber, Matthew J Grigg, Timothy William, Christian R Engwerda, Nicholas M Anstey and 3 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Malaria journal, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.2field-weighted citation impact, top 51% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 3 institutions in 2 countries.

Jessica R LoughlandMenzies School of Health Research and Charles Darwin University, Darwin, Australia. Jessica.Loughland@qimrberghofer.edu.au.ORCID http://orcid.org/0000-0003-2253-1577
Tonia WoodberryMenzies School of Health Research and Charles Darwin University, Darwin, Australia.
Damian OyongMenzies School of Health Research and Charles Darwin University, Darwin, Australia.
Kim A PieraMenzies School of Health Research and Charles Darwin University, Darwin, Australia.
Fiona H AmanteQIMR Berghofer Medical Research Institute, Brisbane, Australia.
Bridget E BarberMenzies School of Health Research and Charles Darwin University, Darwin, Australia.
Matthew J GriggMenzies School of Health Research and Charles Darwin University, Darwin, Australia.
Timothy WilliamGleneagles Hospital, Kota Kinabalu, Sabah, Malaysia.
Christian R EngwerdaQIMR Berghofer Medical Research Institute, Brisbane, Australia.
Nicholas M AnsteyMenzies School of Health Research and Charles Darwin University, Darwin, Australia.
James S McCarthyQIMR Berghofer Medical Research Institute, Brisbane, Australia.
Michelle J BoyleMenzies School of Health Research and Charles Darwin University, Darwin, Australia.
Gabriela MinigoMenzies School of Health Research and Charles Darwin University, Darwin, Australia. Gabriela.Minigo@cdu.edu.au.ORCID https://orcid.org/0000-0001-5158-7700
Charles Darwin University · AUQIMR Berghofer Medical Research Institute · AUMinistry of Health · MY

Funding

Comparative incidence and clinical spectrum of Plasmodium knowlesi malaria, a longitudinal study in Sabah, MalaysiaR01AI116472 · NIAID · INFECTIOUS DISEASE SOCIETY KOTA KINABALU · PI WILLIAM, TIMOTHY · 2015 to 2019
$682k
Foundation for the National Institutes of Health R01 AI116472-03National Health and Medical Research Council 1021198National Health and Medical Research Council 1037304National Health and Medical Research Council 1042072National Health and Medical Research Council 1045156National Health and Medical Research Council 1092789National Health and Medical Research Council 1125656National Health and Medical Research Council 1132975National Health and Medical Research Council 1135955National Health and Medical Research Council 1138860National Health and Medical Research Council 1141632National Health and Medical Research Council 1154265National Health and Medical Research Council 545245NIAID NIH HHS R01 AI116472
6 · The paper itself

Abstract

backgroundPlasmodium falciparum malaria increases plasma levels of the cytokine Fms-like tyrosine kinase 3 ligand (Flt3L), a haematopoietic factor associated with dendritic cell (DC) expansion. It is unknown if the zoonotic parasite Plasmodium knowlesi impacts Flt3L or DC in human malaria. This study investigated circulating DC and Flt3L associations in adult malaria and in submicroscopic experimental infection.

methodsPlasma Flt3L concentration and blood CD141

resultsPlasmodium knowlesi caused a decline in all circulating DC subsets in adults with malaria. Plasma Flt3L was elevated in acute P. falciparum and P. knowlesi malaria with no increase in a subclinical experimental infection. Circulating CD141

conclusionsIn adults, submicroscopic Plasmodium infection causes no change in plasma Flt3L but does reduce circulating DCs. Plasma Flt3L concentrations increase in acute malaria, yet this increase is insufficient to restore or expand circulating CD141

Indexed as

Acute DiseaseAdultDendritic CellsFemaleHumansMalariaMalaria, FalciparumMaleMembrane ProteinsMiddle AgedPlasmaPlasmodium falciparumPlasmodium knowlesiYoung Adultflt3 ligand proteinMembrane ProteinsBDCA1BDCA3CD141CHMIDendritic cellsFlt3 ligandIBSMPlasmacytoidPlasmodium falciparumPlasmodium knowlesi

Identifiers

PMID33593383
PMCPMC7888183
OpenAlexW3130823574

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.