ArticleBMC pulmonary medicine2021
Novel association between asthma and osteoarthritis: a nationwide health and nutrition examination survey.
Article in BMC pulmonary medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.
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Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it, 40 citations in OpenAlex.
- Genome wide association joint analysis reveals 99 risk loci for pain susceptibility and pleiotropic relationships with psychiatric, metabolic, and immunological traits.PLoS genetics · 2023Pooled it
- Transcriptomic analysis reveals distinct molecular signatures and regulatory networks of osteoarthritic chondrocytes versus mesenchymal stem cells during chondrogenesis.Biomedical papers of the Medical Faculty of the University Palacky, Olomouc, Czechoslovakia · 2025Article
- Long COVID in the population of COVID-19 hospitalized patients discharged from SUS' hospitals in Rio de Janeiro City, Brazil: a patient-engaged cohort survey study.BMC infectious diseases · 2025Article
- Risk of knee osteoarthritis in patients with multiple atopic conditions: a nationwide study.Scientific reports · 2025Article
- Aortic, musculoskeletal and organ characteristics on computed tomography in knee osteoarthritis - an explorative study in the IMI-APPROACH cohort.Rheumatology international · 2025Article
- Asthma, social isolation and loneliness, and risk of incident osteoarthritis.Arthritis research & therapy · 2025Article
- Association of organs-crosstalk with the pathogenesis of osteoarthritis: cartilage as a key player.Frontiers in endocrinology · 2025Review
- Perceptions of sedentary behaviour in people with severe asthma: a qualitative study.BMC public health · 2024Article
- Phenome-wide causal associations between osteoarthritis and other complex traits through the latent causal variable analysis.BMC musculoskeletal disorders · 2024Article
- Comorbidities associated with adult asthma: a population-based matched cohort study in Finland.BMJ open respiratory research · 2024Article
- Genetic association between atopic disease and osteoarthritis.Osteoarthritis and cartilage · 2024Article
- Comorbidity in incident osteoarthritis cases and matched controls using electronic health record data.Arthritis research & therapy · 2023Article
- Increased risk of osteoarthritis in patients with atopic disease.Annals of the rheumatic diseases · 2023Article
- Arthritis and incident pulmonary diseases in middle-aged and elderly Chinese: a longitudinal population-based study.Clinical rheumatology · 2023Article
- Decline of Lung Function in Knee and Spine Osteoarthritis in the Korean Population: Cross-Sectional Analysis of Data from the Korea National Health and Nutrition Examination Survey.Healthcare (Basel, Switzerland) · 2022Article
- Microbiome First Medicine in Health and Safety.Biomedicines · 2021Review
- Article
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
backgroundAsthma and osteoarthritis (OA) are medical conditions that inhibit physical activity and adversely affect quality of life. Despite the high prevalence, there are limited studies focusing on the comorbid condition and association between asthma and OA. The aim of this study was to assess the prevalence of OA co-occurring with asthma and to identify the relevant clinical considerations.
methodsAdult participants aged over 40 years who completed questionnaire assessments and spirometry tests were enrolled from the Korean National Health and Nutrition Examination Survey. Asthma and OA were defined based on the medical history of a diagnosis made by a doctor. Radiographic severities of OA were measured using the Kellgren-Lawrence grading system. Chronic obstructive pulmonary disease (COPD), as a comparative respiratory disease, was diagnosed based on the spirometric results.
resultsA total of 9344 subjects were enrolled, and the prevalence of asthma and COPD were 4.6% ± 0.3% and 12.0% ± 0.5%, respectively. The prevalence of OA in the asthma group was 31.9% ± 2.8%, which was significantly higher than that in the COPD (17.8% ± 1.5%) or control (16.2% ± 0.6%) groups. OA was more prevalent in patients with asthma after adjusting for age, sex, body mass index, and smoking status (OR 1.65; 95% CI 1.27-2.13). Furthermore, after adjustment of this model for the prescription of OA medication, OA remained independently associated with asthma (OR 1.56; 95% CI 1.10-2.20). Conversely, the relationship of OA medication with asthma was not significant (P = 0.64). This relationship was evident in patients with asthma without airflow limitation measured by spirometry (OR 1.97; 95% CI 1.32-2.93). Moreover, the radiographic severity of knee OA correlated with asthma (OR 1.10; 95% CI 1.0-1.21).
conclusionsOA shows a high prevalence in patients with asthma, higher than in patients with COPD or the controls. The comorbid characteristics of these two conditions need to be considered in clinical practice.
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