ArticleBMC infectious diseases2021
Neurologic sequelae of severe chikungunya infection in the first 6 months of life: a prospective cohort study 24-months post-infection.
Article in BMC infectious diseases, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 20 citations in OpenAlex.
- Research advances in chikungunya virus: Epidemiology, pathogenesis, and control.One health (Amsterdam, Netherlands) · 2026Review
- Long-term neurodevelopmental outcomes of children perinatally infected with chikungunya: the CHIK13+ matched cohort study on Reunion Island.EClinicalMedicine · 2026Article
- Interferon-β Modulates Early Viral Replication Kinetics and Innate Responses to Non-Fatal Alphavirus Encephalomyelitis.Pathogens (Basel, Switzerland) · 2026Article
- Neurological and neurodevelopmental outcomes in neonates and children after maternal chikungunya infection in pregnancy: a systematic review and meta-analysis.EClinicalMedicine · 2026Article
- Article
- Global, regional and national burden of chikungunya: force of infection mapping and spatial modelling study.BMJ global health · 2025Article
- [Mother-to-Child Transmission of Chikungunya Virus and Its Impact on the Neonatal Nervous System].Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition · 2025Review
- The possibly neglected victims: Re-examining the involvement of children in the chikungunya epidemic.Pediatric investigation · 2025Article
- Article
- Crosstalk between CD64EMBO molecular medicine · 2024Article
- Trends in emerging vector-borne viral infections and their outcome in children over two decades.Pediatric research · 2024Review
- Antiviral evaluation of 1,4-disubstituted-1,2,3-triazole derivatives against Chikungunya virus.Future virology · 2023Article
- Mechanisms, Effects, and Management of Neurological Complications of Post-Acute Sequelae of COVID-19 (NC-PASC).Biomedicines · 2023Review
- Chikungunya virus infection induces ultrastructural changes and impaired neuronal differentiation of human neurospheres.Frontiers in microbiology · 2023Article
- Developing brain under renewed attack: viral infection during pregnancy.Frontiers in neuroscience · 2023Review
- Cognitive Dysfunction of Chikungunya Virus Infection in Older Adults.Frontiers in psychiatry · 2022Article
- Cardiomyopathy and Death Following Chikungunya Infection: An Increasingly Common Outcome.Tropical medicine and infectious disease · 2021Review
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPerinatally chikungunya infected neonates have been reported to have high rates of post-infection neurologic sequelae, mainly cognitive problems. In older children and adults chikungunya does not appear to have sequelae, but data on postnatally infected infants are lacking.
methodsWe performed a prospective, non-controlled, observational study of infants infected before the age of 6 months with a severe chikungunya infection during the 2014-2015 epidemic in Curaçao, Dutch Antilles. Two years post-infection cognitive and motor - (BSID-III) and social emotional assessments (ITSEA) were performed.
resultsOf twenty-two infected infants, two died and two were lost to follow up. Eighteen children were seen at follow-up and included in the current study. Of these, 13 (72%) had abnormal scores on the BSID-III (cognitive/motor) or ITSEA.
conclusionIn the first study aimed at postnatally infected infants, using an uncontrolled design, we observed a very high percentage of developmental problems. Further studies are needed to assess causality, however until these data are available preventive measure during outbreaks should also include young infants. Those that have been infected in early infancy should receive follow up.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.