Evidence map›Paper›PMID 33593300›Full record

ArticleBMC gastroenterology2021

Extra-esophageal symptoms in individuals with and without erosive esophagitis: a case-control study in Albania.

Edite Sadiku, Eqerem Hasani, Indrit Këlliçi, Iris Mone, Fatjona Kraja, Bledar Kraja, Genc Burazeri

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC gastroenterology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 2 pooled it
0.7field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 2 syntheses or guidelines pooled it, 4 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 2 countries.

Edite Sadiku *University Clinic of Gastrohepatology and Hepatology Service, University Hospital Center "Mother Teresa", Dibra Street 371, 1001, Tirana, Albania.
Eqerem Hasani *Emergency Departments, University Hospital Center Mother Teresa, Dibra Street 371, Tirana, Albania.
Indrit KëlliçiDivision of Physiology, Department of Biomedical and Experimental Sciences, Faculty of Medicine, University of Medicine, Dibra Street 371, Tirana, Albania.
Iris MoneDivision of Physiology, Department of Biomedical and Experimental Sciences, Faculty of Medicine, University of Medicine, Dibra Street 371, Tirana, Albania.
Fatjona KrajaDivision of Physiology, Department of Biomedical and Experimental Sciences, Faculty of Medicine, University of Medicine, Dibra Street 371, Tirana, Albania.
Bledar KrajaUniversity Clinic of Gastrohepatology and Hepatology Service, University Hospital Center "Mother Teresa", Dibra Street 371, 1001, Tirana, Albania. bledarkraja@yahoo.com.
Genc BurazeriDepartment of International Health, School for Public Health and Primary Care (CAPHRI), Faculty of Health, Medicine and Life Sciences, Maastricht University, 6200 MD, Maastricht, The Netherlands.
Mother Teresa Hospital · ALUniversity of Medicine Tirana · ALMaastricht University · NL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionErosive reflux esophagitis caused a large clinical spectrum of symptoms. Our aim was to assess the prevalence of extra-esophageal symptoms in individuals with and those without erosive esophagitis in Albania.

methodsA case-control study was conducted at the Regional Hospital of Durres, the second main district in Albania, a transitional country in South Eastern Europe, including 248 patients with erosive esophagitis (aged 46.5 ± 16.3 years) and 273 controls (aged 46.4 ± 16.0 years; response rate: 70%) enrolled during the period January 2013-June 2014. Both cases and controls underwent upper endoscopy. Information on socio-demographic characteristics and lifestyle factors was also collected. Binary logistic regression was used to assess the association of erosive esophagitis and extra-esophageal symptoms.

resultsPatients with erosive esophagitis had a higher prevalence of excessive alcohol consumption, smoking, sedentarity, non-Mediterranean diet and obesity compared to their control counterparts (9% vs. 5%, 70% vs. 49%, 31% vs. 17%, 61% vs. 49% and 22% vs. 9%, respectively). Upon adjustment for all socio-demographic characteristics and lifestyle/behavioral factors, there was evidence of a strong association of erosive esophagitis with chronic cough (OR = 3.2, 95% CI = 1.7-5.8), and even more so with laryngeal disorders (OR = 4.4, 95% CI = 2.6-7.5). In all models, the association of erosive esophagitis with any extra-esophageal symptoms was strong and mainly consistent with each of the symptoms separately (fully-adjusted model: OR = 4.6, 95% CI = 2.9-7.3).

conclusionOur findings indicate that the prevalence of extra-esophageal symptoms is higher among patients with erosive esophagitis in a transitional country characterized conventionally by employment of a Mediterranean diet.

Indexed as

EsophagitisEsophagitis, PepticGastroesophageal RefluxAdultAlbaniaCase-Control StudiesHumansMiddle AgedRisk FactorsAlbaniaErosive reflux esophagitisExtra-esophageal symptomsGERD

Identifiers

PMID33593300
PMCPMC7885502
OpenAlexW3113288580

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.