Evidence map›Paper›PMID 33593074›Full record

ArticleCirculation research2021

Loss of CASK Accelerates Heart Failure Development.

Julian Mustroph, Can M Sag, Felix Bähr, Anna-Lena Schmidtmann, Shamindra N Gupta, Alexander Dietz, M M Towhidul Islam, Charlotte Lücht, Bo Eric Beuthner, Steffen Pabel and 15 more

Open access · bronzeAbstract read
In one paragraph

Article in Circulation research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
1.4field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 17 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Review
  5. Ion channel trafficking implications in heart failure.Frontiers in cardiovascular medicine · 2024
    Review
  6. Review
  7. Mosaicism of a Truncating Variant ofMolecular syndromology · 2023
    Article
  8. Article
  9. Review
  10. An Overview of the Cardiorenal Protective Mechanisms of SGLT2 Inhibitors.International journal of molecular sciences · 2022
    Review
  11. Review
  12. Review
  13. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

25 authors at 8 institutions in 4 countries.

Julian MustrophDepartment of Internal Medicine II, University Medical Center Regensburg, Germany (J. Mustroph, C.M.S., C.L., S.P., M.J.B., S.S., B.U., L.S.M., S.W.).
Can M SagDepartment of Internal Medicine II, University Medical Center Regensburg, Germany (J. Mustroph, C.M.S., C.L., S.P., M.J.B., S.S., B.U., L.S.M., S.W.).
Felix BährCardiology & Pneumology, University Medical Center Göttingen, Germany (F.B., A.-L.S., S.N.G., A.D., M.M.T.I., B.E.B., S.S.).
Anna-Lena SchmidtmannCardiology & Pneumology, University Medical Center Göttingen, Germany (F.B., A.-L.S., S.N.G., A.D., M.M.T.I., B.E.B., S.S.).
Shamindra N GuptaCardiology & Pneumology, University Medical Center Göttingen, Germany (F.B., A.-L.S., S.N.G., A.D., M.M.T.I., B.E.B., S.S.).
Alexander DietzCardiology & Pneumology, University Medical Center Göttingen, Germany (F.B., A.-L.S., S.N.G., A.D., M.M.T.I., B.E.B., S.S.).
M M Towhidul IslamCardiology & Pneumology, University Medical Center Göttingen, Germany (F.B., A.-L.S., S.N.G., A.D., M.M.T.I., B.E.B., S.S.).
Charlotte LüchtDepartment of Internal Medicine II, University Medical Center Regensburg, Germany (J. Mustroph, C.M.S., C.L., S.P., M.J.B., S.S., B.U., L.S.M., S.W.).
Bo Eric BeuthnerCardiology & Pneumology, University Medical Center Göttingen, Germany (F.B., A.-L.S., S.N.G., A.D., M.M.T.I., B.E.B., S.S.).
Steffen PabelDepartment of Internal Medicine II, University Medical Center Regensburg, Germany (J. Mustroph, C.M.S., C.L., S.P., M.J.B., S.S., B.U., L.S.M., S.W.).
Maria J BaierDepartment of Internal Medicine II, University Medical Center Regensburg, Germany (J. Mustroph, C.M.S., C.L., S.P., M.J.B., S.S., B.U., L.S.M., S.W.).
Ali El-ArmoucheDepartment of Pharmacology and Toxicology, Technical University Dresden, Germany (A.E.-A.).
Samuel SossallaDepartment of Internal Medicine II, University Medical Center Regensburg, Germany (J. Mustroph, C.M.S., C.L., S.P., M.J.B., S.S., B.U., L.S.M., S.W.).
Mark E AndersonJohns Hopkins School of Medicine, Baltimore (M.E.A.).
Julia MöllmannClinic for Cardiology, Angiology, and Internal Intensive Care, University Clinic Aachen, Germany (J. Möllmann, M.L., N.M.).
Michael LehrkeClinic for Cardiology, Angiology, and Internal Intensive Care, University Clinic Aachen, Germany (J. Möllmann, M.L., N.M.).
Nikolaus MarxClinic for Cardiology, Angiology, and Internal Intensive Care, University Clinic Aachen, Germany (J. Möllmann, M.L., N.M.).
Peter J MohlerCollege of Medicine, the Ohio State University Wexner Medical Center, Columbus (P.J.M.).
Donald M BersCollege of Biological Sciences, University of California at Davis (D.M.B.).
Bernhard UnsöldDepartment of Internal Medicine II, University Medical Center Regensburg, Germany (J. Mustroph, C.M.S., C.L., S.P., M.J.B., S.S., B.U., L.S.M., S.W.).
Tao HeDepartment of Molecular Cardiology and Epigenetics, University Clinic Heidelberg, Germany (T.H., M.D., J.B.).
Matthias DewenterDepartment of Molecular Cardiology and Epigenetics, University Clinic Heidelberg, Germany (T.H., M.D., J.B.).
Johannes BacksDepartment of Molecular Cardiology and Epigenetics, University Clinic Heidelberg, Germany (T.H., M.D., J.B.).
Lars S Maier *Department of Internal Medicine II, University Medical Center Regensburg, Germany (J. Mustroph, C.M.S., C.L., S.P., M.J.B., S.S., B.U., L.S.M., S.W.).
Stefan Wagner *Department of Internal Medicine II, University Medical Center Regensburg, Germany (J. Mustroph, C.M.S., C.L., S.P., M.J.B., S.S., B.U., L.S.M., S.W.).
Muscular Dystrophy Association · USNorwegian Womens Public Health Association · NOMedigene (Germany) · DEUniversity Clinic of Traumatology · ATJohns Hopkins University · USTechnische Universität Dresden · DEThe Ohio State University Wexner Medical Center · USUniversity of California, Davis · US

Funding

Pathophysiological Regulation of Cardiac Myocyte RyR ChannelR01HL092097 · NHLBI · UNIVERSITY OF CALIFORNIA AT DAVIS · PI Donald M Bers, Robyn T Rebbeck · 2010 to 2026
$9.3M
Defining novel mechanisms for human arrhythmiaR35HL135754 · NHLBI · OHIO STATE UNIVERSITY · PI MOHLER, PETER J. · 2017 to 2023
$6.0M
CaMKII activation and regulation in adult cardiac myocytesR01HL142282 · NHLBI · UNIVERSITY OF CALIFORNIA AT DAVIS · PI BERS, DONALD M, BOSSUYT, JULIE B · 2018 to 2025
$5.4M
CaMKII signaling in physiology, heart failure and arrhythmiasR35HL140034 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI ANDERSON, MARK E · 2018 to 2022
$5.2M
Mitochondrial Calmodulin Kinase II in Physiology and DiseaseR01HL070250 · NHLBI · VANDERBILT UNIVERSITY · PI ANDERSON, MARK E · 2002 to 2017
$5.2M
Methionine sulfoxide reductase A and oxidized CaMKII in structural heart diseaseR01HL079031 · NHLBI · UNIVERSITY OF IOWA · PI ANDERSON, MARK E · 2006 to 2015
$3.3M
CaMKII in Sinus Node Physiology and DiseaseR01HL096652 · NHLBI · UNIVERSITY OF IOWA · PI ANDERSON, MARK E · 2009 to 2016
$3.0M
Defining novel mechanisms for regulation of atrial INa and arrhythmiasR01HL134824 · NHLBI · OHIO STATE UNIVERSITY · PI HUND, THOMAS JEFFREY, MOHLER, PETER J. · 2017 to 2020
$3.0M
EHD proteins in cardiac membrane protein targeting and remodelingR01HL114383 · NHLBI · OHIO STATE UNIVERSITY · PI BOYDEN, PENELOPE ALTMAN, MOHLER, PETER J. · 2013 to 2016
$2.1M
Oxidized CaMKII in Atrial FibrillationR01HL113001 · NHLBI · UNIVERSITY OF IOWA · PI ANDERSON, MARK E · 2012 to 2016
$1.9M
NHLBI NIH HHS R01 HL070250NHLBI NIH HHS R01 HL079031NHLBI NIH HHS R01 HL092097NHLBI NIH HHS R01 HL096652NHLBI NIH HHS R01 HL113001NHLBI NIH HHS R01 HL114383NHLBI NIH HHS R01 HL134824NHLBI NIH HHS R01 HL142282NHLBI NIH HHS R35 HL135754NHLBI NIH HHS R35 HL140034
6 · The paper itself

Abstract

[Figure: see text].

Indexed as

AnimalsCalciumCalcium-Calmodulin-Dependent Protein Kinase Type 2Cells, CulturedGlucagon-Like Peptide-1 ReceptorGuanylate KinasesHeart FailureHeart RateHumansMaleMiceMice, Inbred C57BLMyocardial ContractionMyocytes, CardiacCalciumCalcium-Calmodulin-Dependent Protein Kinase Type 2CASK kinasesGlucagon-Like Peptide-1 ReceptorGuanylate Kinasescalmodulinheart failuremyocardiumneuronssarcoplasmic reticulum

Identifiers

PMID33593074
PMCPMC8049978
OpenAlexW3133335672

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.