Evidence map›Paper›PMID 33593071›Full record

ArticleCirculation2021

Excessive

Priya Umapathi, Olurotimi O Mesubi, Partha S Banerjee, Neha Abrol, Qinchuan Wang, Elizabeth D Luczak, Yuejin Wu, Jonathan M Granger, An-Chi Wei, Oscar E Reyes Gaido and 5 more

Erratum issuedOpen access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Circulation, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 85 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
85citing papers in PubMed, 1 pooled it
7.1field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

85 citing papers in PubMed, 1 synthesis or guideline pooled it, 126 citations in OpenAlex.

  1. Pooled it
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  5. Review
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  17. TargetingbioRxiv : the preprint server for biology · 2025
    Article
  18. Review
  19. Shared genetic associations between CHAInternational journal of cardiology. Cardiovascular risk and prevention · 2025
    Article
  20. Article

25 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

15 authors at 4 institutions in 2 countries.

Priya UmapathiDivision of Cardiology (P.U., O.O.M., N.A., Q.W., E.D.L., Y.W., J.M.G., O.E.R.G., M.E.A.), The Johns Hopkins University School of Medicine, Baltimore, MD.
Olurotimi O MesubiDivision of Cardiology (P.U., O.O.M., N.A., Q.W., E.D.L., Y.W., J.M.G., O.E.R.G., M.E.A.), The Johns Hopkins University School of Medicine, Baltimore, MD.
Partha S BanerjeeDepartment of Biological Chemistry (P.S.B., G.W.H., N.E.Z.), The Johns Hopkins University School of Medicine, Baltimore, MD.
Neha AbrolDivision of Cardiology (P.U., O.O.M., N.A., Q.W., E.D.L., Y.W., J.M.G., O.E.R.G., M.E.A.), The Johns Hopkins University School of Medicine, Baltimore, MD.
Qinchuan WangDivision of Cardiology (P.U., O.O.M., N.A., Q.W., E.D.L., Y.W., J.M.G., O.E.R.G., M.E.A.), The Johns Hopkins University School of Medicine, Baltimore, MD.
Elizabeth D LuczakDivision of Cardiology (P.U., O.O.M., N.A., Q.W., E.D.L., Y.W., J.M.G., O.E.R.G., M.E.A.), The Johns Hopkins University School of Medicine, Baltimore, MD.
Yuejin WuDivision of Cardiology (P.U., O.O.M., N.A., Q.W., E.D.L., Y.W., J.M.G., O.E.R.G., M.E.A.), The Johns Hopkins University School of Medicine, Baltimore, MD.
Jonathan M GrangerDivision of Cardiology (P.U., O.O.M., N.A., Q.W., E.D.L., Y.W., J.M.G., O.E.R.G., M.E.A.), The Johns Hopkins University School of Medicine, Baltimore, MD.
An-Chi WeiDepartment of Electrical Engineering, Graduate Institute of Biomedical Electronics and Bioinformatics, National Taiwan University (A.-C.W.).
Oscar E Reyes GaidoDivision of Cardiology (P.U., O.O.M., N.A., Q.W., E.D.L., Y.W., J.M.G., O.E.R.G., M.E.A.), The Johns Hopkins University School of Medicine, Baltimore, MD.
Liliana FloreaDepartment of Medicine (P.U., O.O.M., N.A., Q.W., E.D.L., Y.W., J.M.G., L.F., M.E.A.), The Johns Hopkins University School of Medicine, Baltimore, MD.
C Conover TalbotInstitute for Basic Biomedical Sciences (C.C.T.), The Johns Hopkins University School of Medicine, Baltimore, MD.
Gerald W HartThe Complex Carbohydrate Research Center and Department of Biochemistry and Molecular Biology, University of Georgia, Athens (G.W.H.).
Natasha E ZacharaDepartment of Biological Chemistry (P.S.B., G.W.H., N.E.Z.), The Johns Hopkins University School of Medicine, Baltimore, MD.
Mark E AndersonDivision of Cardiology (P.U., O.O.M., N.A., Q.W., E.D.L., Y.W., J.M.G., O.E.R.G., M.E.A.), The Johns Hopkins University School of Medicine, Baltimore, MD.
Johns Hopkins University · USMACOM (United States) · USNational Taiwan University · TWUniversity of Georgia · US

Funding

PATHOPHYSIOLOGY OF MYOCARDIAL DISEASEST32HL007227 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI Chulan Kwon, WENDY S POST · 1985 to 2026
$21.2M
Shared Resource CoresP01HL107153 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI VAN EYK, JENNIFER E · 2011 to 2017
$16.8M
CaMKII signaling in physiology, heart failure and arrhythmiasR35HL140034 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI ANDERSON, MARK E · 2018 to 2022
$5.2M
Immersive Training in GlycosciencesK12HL141952 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI HASCALL, VINCENT CHARLES, SCHNAAR, RONALD L · 2018 to 2022
$4.8M
Regulation of O-GlcNAcylation During InjuryR01HL139640 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI ZACHARA, NATASHA ELIZABETH · 2018 to 2021
$1.6M
Computational Methods to Characterize Alternative Splicing from Massive Collections of RNA-seq DataR01GM129085 · NIGMS · JOHNS HOPKINS UNIVERSITY · PI FLOREA, LILIANA D · 2019 to 2022
$1.5M
NHLBI NIH HHS K12 HL141952NHLBI NIH HHS P01 HL107153NHLBI NIH HHS R01 HL139640NHLBI NIH HHS R35 HL140034NHLBI NIH HHS T32 HL007227NIGMS NIH HHS R01 GM129085
6 · The paper itself

Abstract

backgroundHeart failure is a leading cause of death worldwide and is associated with the rising prevalence of obesity, hypertension, and diabetes.

methodsWe developed 2 new transgenic mouse models with myocardial overexpression of OGT and OGA to control

resultsWe found that OGT transgenic hearts showed increased

conclusionsOur data provide evidence that excessive

Indexed as

AnimalsDeath, SuddenDisease Models, AnimalHeart FailureHumansMiceMice, TransgenicN-AcetylglucosaminyltransferasesN-AcetylglucosaminyltransferasesO-GlcNAc transferaseCaMKIIcardiac arrhythmiaheart failurehypertensionhypertrophypost-translational protein processingUridine diphosphate N-acetylglucosamine

Identifiers

PMID33593071
PMCPMC8085112
OpenAlexW3131737902

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.