Evidence map›Paper›PMID 33592623›Full record

ArticleAlcohol and alcoholism (Oxford, Oxfordshire)2021

Endotoxin for Alcohol Research: A Call for Experimental Medicine Using Lipopolysaccharide Challenge.

Elizabeth M Burnette, Erica N Grodin, Naomi I Eisenberger, Lara A Ray

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Alcohol and alcoholism (Oxford, Oxfordshire), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact, top 78% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Trial
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Elizabeth M BurnetteDepartment of Psychology, University of California at Los Angeles, 5555 Campus Hall, Los Angeles, CA 90095, USA.ORCID 0000-0003-4005-5885
Erica N GrodinDepartment of Psychology, University of California at Los Angeles, 5555 Campus Hall, Los Angeles, CA 90095, USA.
Naomi I EisenbergerDepartment of Psychology, University of California at Los Angeles, 5555 Campus Hall, Los Angeles, CA 90095, USA.
Lara A RayDepartment of Psychology, University of California at Los Angeles, 5555 Campus Hall, Los Angeles, CA 90095, USA.
University of California, Los Angeles · US

Funding

UCLA Training Program in Translational Neuroscience of Drug Abuse (TNDA)T32DA024635 · NIDA · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI LARA A. RAY, Kate M Wassum · 2008 to 2026
$6.2M
Clinical Neuroscience of Alcoholism: Integrating Neuroscience and Clinical TrialsK24AA025704 · NIAAA · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI LARA A. RAY · 2018 to 2026
$1.3M
Elucidating the Effects of Neuroimmune Modulation on Neural Substrates of Alcohol Cue and Stress ReactivityF32AA027699 · NIAAA · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI GRODIN, ERICA N · 2019 to 2020
$103k
Probing Inflammation and Reward Sensitivity in Alcohol Use DisorderF31AA028976 · NIAAA · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI BURNETTE, ELIZABETH · 2020 to 2022
$103k
NIAAA NIH HHS F31 AA028976NIAAA NIH HHS F31AA028976NIAAA NIH HHS F32 AA027699NIAAA NIH HHS K24 AA025704NIDA NIH HHS T32 DA024635
6 · The paper itself

Abstract

Studies of inflammation in alcohol use disorder (AUD) are overwhelmingly preclinical, and translation to clinical samples is necessary. Endotoxin administration has been used successfully in humans to study mood disorders, offering a translational, reliable and safe model that may be validated in AUD research. We argue for the use of endotoxin challenge to elucidate the interplay between AUD and inflammation.

Indexed as

AlcoholismBiomedical ResearchEndotoxinsHumansInflammationLipopolysaccharidesTranslational Research, BiomedicalEndotoxinsLipopolysaccharides

Identifiers

PMID33592623
PMCPMC8557676
OpenAlexW3131944522

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.