ArticleInternational journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases2021
Prioritizing second-generation SARS-CoV-2 vaccines through low-dosage challenge studies.
Article in International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
6 citing papers in PubMed.
- Do coronavirus vaccine challenge trials have a distinctive generalisability problem?Journal of medical ethics · 2022Article
- Pandemic vaccine testing: Combining conventional and challenge studies.Pharmacoepidemiology and drug safety · 2022Article
- The COVID-19 Pandemic and the Need for an Integrated and Equitable Approach: An International Expert Consensus Paper.Thrombosis and haemostasis · 2021Article
- Exploring Risks of Human Challenge Trials For COVID-19.Risk analysis : an official publication of the Society for Risk Analysis · 2021Article
- Vaccine-enhanced disease: case studies and ethical implications for research and public health.Wellcome open research · 2021Article
- Spatio-temporal characteristics of the novel coronavirus attention network and its influencing factors in China.PloS one · 2021Article
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
The design of human challenge studies balances scientific validity, efficiency and study safety. This Perspective explores some advantages and disadvantages of 'low-dosage' challenge studies, in the setting of testing second-generation vaccines against COVID-19. Compared with a conventional vaccine challenge, a low-dosage vaccine challenge would be more likely to start, and start earlier. A low-dosage challenge would also be less likely to rule out a vaccine candidate that would have potentially been effective, particularly in certain target uses. A key ethical advantage of a low-dosage challenge over a conventional challenge is that both it and its dose escalation process are safer for each participant. Low-dosage studies would require larger numbers of participants than conventional challenges, but this and other potential disadvantages are less serious than they may initially appear. Overall, low-dosage challenges should be considered for certain roles such as prioritizing between second-generation vaccines against COVID-19.
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Registered trials
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