Evidence map›Paper›PMID 33592287›Full record

ArticleMolecular and cellular endocrinology2021

ERβ regulated ovarian kisspeptin plays an important role in oocyte maturation.

V Praveen Chakravarthi, Subhra Ghosh, Sami M Housami, Huizhen Wang, Katherine F Roby, Michael W Wolfe, William H Kinsey, M A Karim Rumi

Open access · greenAbstract read
In one paragraph

Article in Molecular and cellular endocrinology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed, 1 pooled it
1.4field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 1 synthesis or guideline pooled it, 23 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Article
  4. Article
  5. Review
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Review
  13. Review
  14. Review
  15. ERβ Regulation of Gonadotropin Responses during Folliculogenesis.International journal of molecular sciences · 2021
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

V Praveen ChakravarthiDepartment of Pathology and Laboratory Medicine, USA.
Subhra GhoshDepartment of Pathology and Laboratory Medicine, USA.
Sami M HousamiDepartment of Molecular and Integrative Physiology, USA.
Huizhen WangDepartment of Anatomy and Cell Biology, USA.
Katherine F RobyDepartment of Anatomy and Cell Biology, USA; Institute for Reproduction and Perinatal Research, University of Kansas Medical Center, Kansas City, KS, USA.
Michael W WolfeDepartment of Molecular and Integrative Physiology, USA; Institute for Reproduction and Perinatal Research, University of Kansas Medical Center, Kansas City, KS, USA.
William H KinseyDepartment of Anatomy and Cell Biology, USA; Institute for Reproduction and Perinatal Research, University of Kansas Medical Center, Kansas City, KS, USA.
M A Karim RumiDepartment of Pathology and Laboratory Medicine, USA; Institute for Reproduction and Perinatal Research, University of Kansas Medical Center, Kansas City, KS, USA. Electronic address: mrumi@kumc.edu.
University of Kansas Medical Center · US

Funding

Mentoring CoreP20GM103418 · NIGMS · UNIVERSITY OF KANSAS MEDICAL CENTER · PI Douglas E Wright · 2012 to 2026
$63.0M
Molecular Regulation of Cell Development and Differentiation Phase III COBREP30GM122731 · NIGMS · UNIVERSITY OF KANSAS MEDICAL CENTER · PI ABRAHAMSON, DALE R · 2017 to 2021
$5.6M
NIGMS NIH HHS P20 GM103418NIGMS NIH HHS P30 GM122731
6 · The paper itself

Abstract

Kisspeptin (KISS1) signaling in the hypothalamic-pituitary (H-P) axis plays an essential role in regulating gonadotropin secretion. KISS1 and KISS1 receptor (KISS1R) are also expressed in the ovary; however, the role of intraovarian KISS1 signaling remains unclear. Granulosa cell (GC)-specific expression of KISS1, and oocyte-specific expression of KISS1R indicate that GC-derived KISS1 may act on oocytes. Expression of KISS1 in GCs is induced by gonadotropins but it is absent in estrogen receptor β knockout (Erβ

Indexed as

MAP Kinase Signaling SystemAnimalsEstrogen Receptor betaFemaleGranulosa CellsKisspeptinsMitogen-Activated Protein Kinase 1Mitogen-Activated Protein Kinase 3OocytesRatsRats, Sprague-DawleyRats, TransgenicEstrogen Receptor betaKiss1 protein, ratKisspeptinsMapk1 protein, ratMitogen-Activated Protein Kinase 1Mitogen-Activated Protein Kinase 3And oocyte maturationEstrogen receptor βGonadotropinGranulosa cellsKisspeptinKisspeptin receptor

Identifiers

PMID33592287
PMCPMC8906370
OpenAlexW3132913291

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.