Evidence map›Paper›PMID 33592190›Full record

ArticleCurrent biology : CB2021

Centrosome amplification mediates small extracellular vesicle secretion via lysosome disruption.

Sophie D Adams, Judit Csere, Gisela D'angelo, Edward P Carter, Maryse Romao, Teresa Arnandis, Martin Dodel, Hemant M Kocher, Richard Grose, Graça Raposo and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Current biology : CB, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.

0numbers the graph read from it
0cells of the map it votes in
41citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

41 citing papers in PubMed.

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  9. DysregulatedLife science alliance · 2025
    Article
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

12 authors.

Sophie D AdamsCentre for Cancer Cell and Molecular Biology, Barts Cancer Institute, Queen Mary University of London, Charterhouse Square, London EC1M 6BQ, UK.
Judit CsereCentre for Cancer Cell and Molecular Biology, Barts Cancer Institute, Queen Mary University of London, Charterhouse Square, London EC1M 6BQ, UK.
Gisela D'angeloStructure and Membrane Compartments, Institute Curie, Paris Sciences & Lettres Research University, Centre for National de la Recherche Scientifique, UMR144, Paris, France.
Edward P CarterCentre for Tumour Biology, Barts Cancer Institute, Queen Mary University of London, Charterhouse Square, London EC1M 6BQ, UK.
Maryse RomaoStructure and Membrane Compartments, Institute Curie, Paris Sciences & Lettres Research University, Centre for National de la Recherche Scientifique, UMR144, Paris, France.
Teresa ArnandisCentre for Cancer Cell and Molecular Biology, Barts Cancer Institute, Queen Mary University of London, Charterhouse Square, London EC1M 6BQ, UK.
Martin DodelCentre for Cancer Cell and Molecular Biology, Barts Cancer Institute, Queen Mary University of London, Charterhouse Square, London EC1M 6BQ, UK.
Hemant M KocherCentre for Tumour Biology, Barts Cancer Institute, Queen Mary University of London, Charterhouse Square, London EC1M 6BQ, UK.
Richard GroseCentre for Tumour Biology, Barts Cancer Institute, Queen Mary University of London, Charterhouse Square, London EC1M 6BQ, UK.
Graça RaposoStructure and Membrane Compartments, Institute Curie, Paris Sciences & Lettres Research University, Centre for National de la Recherche Scientifique, UMR144, Paris, France.
Faraz MardakhehCentre for Cancer Cell and Molecular Biology, Barts Cancer Institute, Queen Mary University of London, Charterhouse Square, London EC1M 6BQ, UK.
Susana A GodinhoCentre for Cancer Cell and Molecular Biology, Barts Cancer Institute, Queen Mary University of London, Charterhouse Square, London EC1M 6BQ, UK. Electronic address: s.godinho@qmul.ac.uk.

Funding

Cancer Research UK 27781Cancer Research UK C10847/A27781Cancer Research UK C355/A25137Medical Research Council MR/P009417/1Medical Research Council MR/T000538/1
6 · The paper itself

Abstract

Bidirectional communication between cells and their surrounding environment is critical in both normal and pathological settings. Extracellular vesicles (EVs), which facilitate the horizontal transfer of molecules between cells, are recognized as an important constituent of cell-cell communication. In cancer, alterations in EV secretion contribute to the growth and metastasis of tumor cells. However, the mechanisms underlying these changes remain largely unknown. Here, we show that centrosome amplification is associated with and sufficient to promote small extracellular vesicle (

Indexed as

CentrosomeExtracellular VesiclesLysosomesAnimalsHumansMiceMultivesicular BodiesPancreatic Neoplasmscancercentrosome amplificationexosomesextracellular vesiclesinvasionlysosomesmultivesicular bodiesPDACROSstellate cells

Identifiers

PMID33592190
PMCPMC8047808

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.