ArticleStructure (London, England : 1993)2021
A common binding motif in the ET domain of BRD3 forms polymorphic structural interfaces with host and viral proteins.
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Article in Structure (London, England : 1993), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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19citing papers in PubMed
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19 citing papers in PubMed, 35 citations in OpenAlex.
- Loop Plasticity Drives Paralog-Specific Recognition in BET ET Domains.Journal of chemical information and modeling · 2026Article
- Efficient exploration of peptide libraries using active learning with AlphaFold-based screening.bioRxiv : the preprint server for biology · 2026Article
- Predicting Pose Distribution of Protein Domains Connected by Flexible Linkers Is an Unsolved Problem.Proteins · 2026Article
- Loop Plasticity Drives Paralog-Specific Recognition in BET ET Domains.bioRxiv : the preprint server for biology · 2025Article
- Design of intrinsically disordered region binding proteins.Science (New York, N.Y.) · 2025Article
- A Minireview on BET Inhibitors: Beyond Bromodomain Targeting.Biomedicines · 2025Review
- Integrative Modeling of Protein-Polypeptide Complexes by Bayesian Model Selection using AlphaFold and NMR Chemical Shift Perturbation Data.bioRxiv : the preprint server for biology · 2024Article
- A Review of the Bromodomain and Extraterminal Domain Epigenetic Reader Proteins: Function on Virus Infection and Cancer.Viruses · 2024Review
- A Computational Pipeline for Accurate Prioritization of Protein-Protein Binding Candidates in High-Throughput Protein Libraries.Angewandte Chemie (International ed. in English) · 2024Article
- Structural studies of intrinsically disordered MLL-fusion protein AF9 in complex with peptidomimetic inhibitors.Protein science : a publication of the Protein Society · 2024Article
- Sifting Through the Noise: A Computational Pipeline for Accurate Prioritization of Protein-Protein Binding Candidates in High-Throughput Protein Libraries.bioRxiv : the preprint server for biology · 2024Article
- From PROTAC to inhibitor: Structure-guided discovery of potent and orally bioavailable BET inhibitors.European journal of medicinal chemistry · 2023Article
- Structure Determination of Challenging Protein-Peptide Complexes Combining NMR Chemical Shift Data and Molecular Dynamics Simulations.Journal of chemical information and modeling · 2023Article
- BET Bromodomain Inhibitors: Novel Design Strategies and Therapeutic Applications.Molecules (Basel, Switzerland) · 2023Review
- Computational approaches for the design of modulators targeting protein-protein interactions.Expert opinion on drug discovery · 2023Review
- Towards rational computational peptide design.Frontiers in bioinformatics · 2022Article
- Structure and function of retroviral integrase.Nature reviews. Microbiology · 2022Review
- Simultaneous Assignment and Structure Determination of Proteins From Sparsely Labeled NMR Datasets.Frontiers in molecular biosciences · 2021Article
- Computational Modeling as a Tool to Investigate PPI: From Drug Design to Tissue Engineering.Frontiers in molecular biosciences · 2021Review
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Authors and funding
9 authors at 2 institutions in 1 country.
Sriram AiyerDepartment of Pharmacology, Robert Wood Johnson Medical School, Rutgers University, Piscataway, NJ 08854, USA; Department of Biochemistry and Molecular Biology, Robert Wood Johnson Medical School, Rutgers University, Piscataway, NJ 08854, USA.
G V T SwapnaDepartment of Pharmacology, Robert Wood Johnson Medical School, Rutgers University, Piscataway, NJ 08854, USA; Department of Biochemistry and Molecular Biology, Robert Wood Johnson Medical School, Rutgers University, Piscataway, NJ 08854, USA.
Li-Chung MaDepartment of Pharmacology, Robert Wood Johnson Medical School, Rutgers University, Piscataway, NJ 08854, USA; Department of Biochemistry and Molecular Biology, Robert Wood Johnson Medical School, Rutgers University, Piscataway, NJ 08854, USA.
Gaohua LiuDepartment of Biochemistry and Molecular Biology, Robert Wood Johnson Medical School, Rutgers University, Piscataway, NJ 08854, USA.
Jingzhou HaoDepartment of Biochemistry and Molecular Biology, Robert Wood Johnson Medical School, Rutgers University, Piscataway, NJ 08854, USA; Department of Chemistry and Chemical Biology, Center for Biotechnology and Interdisciplinary Sciences, Rensselaer Polytechnic Institute, Troy, NY 12180, USA.
Gordon ChalmersDepartment of Chemistry and Chemical Biology, Center for Biotechnology and Interdisciplinary Sciences, Rensselaer Polytechnic Institute, Troy, NY 12180, USA.
Brian C JacobsDepartment of Pharmacology, Robert Wood Johnson Medical School, Rutgers University, Piscataway, NJ 08854, USA.
Gaetano T MontelioneDepartment of Biochemistry and Molecular Biology, Robert Wood Johnson Medical School, Rutgers University, Piscataway, NJ 08854, USA; Department of Chemistry and Chemical Biology, Center for Biotechnology and Interdisciplinary Sciences, Rensselaer Polytechnic Institute, Troy, NY 12180, USA. Electronic address: monteg3@rpi.edu.
Monica J RothDepartment of Pharmacology, Robert Wood Johnson Medical School, Rutgers University, Piscataway, NJ 08854, USA; Department of Biochemistry and Molecular Biology, Robert Wood Johnson Medical School, Rutgers University, Piscataway, NJ 08854, USA. Electronic address: roth@rwjms.rutgers.edu.
Rutgers, The State University of New Jersey · USRensselaer Polytechnic Institute · US
Funding
Targeting retroviral and virus-like particles for gene and protein deliveryR35GM122518 · NIGMS · RUTGERS BIOMEDICAL AND HEALTH SCIENCES · PI Monica J. Roth · 2017 to 2026
$5.5MMembrane Protein Structure Using Evolutionary Couplings and Sparse NMR DataR01GM120574 · NIGMS · RUTGERS, THE STATE UNIV OF N.J. · PI MONTELIONE, GAETANO T · 2017 to 2020
$2.3MInteractions of MuLV IN with host proteins and DNAR01GM110639 · NIGMS · RBHS-ROBERT WOOD JOHNSON MEDICAL SCHOOL · PI ROTH, MONICA J. · 2016 to 2017
$754k600 MHZ NMR RF Console with 19F NMR ProbeS10OD018207 · OD · RUTGERS, THE STATE UNIV OF N.J. · PI MONTELIONE, GAETANO T · 2014 to 2014
$440kNIGMS NIH HHS R01 GM110639NIGMS NIH HHS R01 GM120574NIGMS NIH HHS R35 GM122518NIH HHS S10 OD018207
Abstract
The extraterminal (ET) domain of BRD3 is conserved among BET proteins (BRD2, BRD3, BRD4), interacting with multiple host and viral protein-protein networks. Solution NMR structures of complexes formed between the BRD3 ET domain and either the 79-residue murine leukemia virus integrase (IN) C-terminal domain (IN
Indexed as
Binding SitesBromodomain Containing ProteinsHistone-Lysine N-MethyltransferaseHumansHydrophobic and Hydrophilic InteractionsIntegrasesLeukemia Virus, MurineModels, MolecularNuclear ProteinsProtein BindingProtein ConformationTranscription FactorsViral ProteinsBRD3 protein, humanBromodomain Containing ProteinsHistone-Lysine N-MethyltransferaseIntegrasesNSD3 protein, humanNuclear ProteinsTranscription FactorsViral ProteinsBET proteinsBRD3extraterminal domainintegraseinterdomain dynamicsisotope peptide labelingMoloney murine leukemia virusNSD3solution NMR
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