ArticlePLoS genetics2021
Genomic rearrangements generate hypervariable mini-chromosomes in host-specific isolates of the blast fungus.
Article in PLoS genetics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 50 papers.
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50 citing papers in PubMed, 87 citations in OpenAlex.
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- Horizontal transfer of accessory chromosomes in fungi - a regulated process for exchange of genetic material?Heredity · 2026Review
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- Segmental duplications and supernumerary chromosomes drive antifungal drug resistance in Candida auris.Nature communications · 2026Article
- Genetic and Epigenetic Mechanisms Underlying Reversible Adaptive Responses in Fungi.Journal of fungi (Basel, Switzerland) · 2026Review
- Recurrent Chromosome Destabilization Through Repeat-Mediated Rearrangements in a Fungal Pathogen.Genome biology and evolution · 2026Article
- Polymorphism and evolutionary origins of accessory chromosomes in the basidiomycete Tremella fuciformis.Nature communications · 2026Article
- Comparative Genomics Reveals Host-Specific Adaptation ofJournal of fungi (Basel, Switzerland) · 2026Article
- Climatic Variables and Virulence May Contribute to the Population Dynamics of Pyricularia oryzae at Local Scale.MicrobiologyOpen · 2026Article
- Pangenome graph analysis reveals evolution of resistance breaking in spinach downy mildew.PLoS biology · 2026Article
- FoTeRs: a novel family of telomere-associated retrotransposons in Fusarium oxysporum.Mobile DNA · 2025Article
- Evolution of antifungal resistance in the environment.Nature microbiology · 2025Review
- Patterns and mechanisms of fungal genome plasticity.Current biology : CB · 2025Review
- Reference-free identification and pangenome analysis of accessory chromosomes in a major fungal plant pathogen.NAR genomics and bioinformatics · 2025Article
- Evolutionary genomics reveals variation in structure and genetic content implicated in virulence and lifestyle in the genus Gaeumannomyces.BMC genomics · 2025Article
- Dynamic meiotic behavior and evolutionary insights of supernumerary B chromosomes in the hangingflyComparative cytogenetics · 2025Article
- From Natural Hosts to Agricultural Threats: The Evolutionary Journey of Phytopathogenic Fungi.Journal of fungi (Basel, Switzerland) · 2025Review
- Comparative Genomics Reveals Sources of Genetic Variability in the Asexual Fungal Plant Pathogen Colletotrichum lupini.Molecular plant pathology · 2024Article
- Characterization and organization of telomeric-linked helicase (tlh) gene families in Fusarium oxysporum.Current genetics · 2024Article
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Authors and funding
9 authors at 4 institutions in 3 countries.
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Abstract
Supernumerary mini-chromosomes-a unique type of genomic structural variation-have been implicated in the emergence of virulence traits in plant pathogenic fungi. However, the mechanisms that facilitate the emergence and maintenance of mini-chromosomes across fungi remain poorly understood. In the blast fungus Magnaporthe oryzae (Syn. Pyricularia oryzae), mini-chromosomes have been first described in the early 1990s but, until very recently, have been overlooked in genomic studies. Here we investigated structural variation in four isolates of the blast fungus M. oryzae from different grass hosts and analyzed the sequences of mini-chromosomes in the rice, foxtail millet and goosegrass isolates. The mini-chromosomes of these isolates turned out to be highly diverse with distinct sequence composition. They are enriched in repetitive elements and have lower gene density than core-chromosomes. We identified several virulence-related genes in the mini-chromosome of the rice isolate, including the virulence-related polyketide synthase Ace1 and two variants of the effector gene AVR-Pik. Macrosynteny analyses around these loci revealed structural rearrangements, including inter-chromosomal translocations between core- and mini-chromosomes. Our findings provide evidence that mini-chromosomes emerge from structural rearrangements and segmental duplication of core-chromosomes and might contribute to adaptive evolution of the blast fungus.
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