ArticlePLoS neglected tropical diseases2021
Infertility and fecundity loss of Wolbachia-infected Aedes aegypti hatched from quiescent eggs is expected to alter invasion dynamics.
Article in PLoS neglected tropical diseases, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers.
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Who cites it
45 citing papers in PubMed, 72 citations in OpenAlex.
- Wolbachia prevalence in Aedes aegypti across five comunas of Medellín, Colombia: Implications for post-release surveillance.PLoS neglected tropical diseases · 2026Article
- EliminatingInsects · 2026Article
- Interactions between mosquito genetic background and Wolbachia strain affect dengue virus blocking and fitness in South American populations of Aedes aegypti.PLoS neglected tropical diseases · 2026Article
- Wolbachia-driven host miRNAs mediate arthropod reproduction in a Wolbachia density-dependent manner.Communications biology · 2026Article
- Horizons of the Future: Preparedness and Response.Current topics in microbiology and immunology · 2026Review
- Wolbachia introgression in Rio de Janeiro remains at sub-optimal levels 30 months after its decline: challenges in the sustainability of wMel interventions for dengue control.Memorias do Instituto Oswaldo Cruz · 2026Article
- Implications of successive blood feeding on Wolbachia-mediated dengue virus inhibition in Aedes aegypti mosquitoes.Nature communications · 2025Article
- The long-term persistence of the wMel strain in Rio de Janeiro is threatened by poor integrated vector management and bacterium fitness cost on Aedes aegypti.PLoS neglected tropical diseases · 2025Article
- Review
- Changes in the frequency of facultative endosymbionts in insect populations: overview and applications.Entomologia generalis · 2025Article
- Fitness compatibility and dengue virus Inhibition in a Bangladeshi strain of Aedes aegypti infected with the Wolbachia strain wAlbB.Scientific reports · 2025Article
- ExploitingPathogens (Basel, Switzerland) · 2025Review
- Article
- Review
- Variable effects of transient Wolbachia infections on alphaviruses in Aedes aegypti.PLoS neglected tropical diseases · 2024Article
- Wolbachia confers protection against the entomopathogenic fungus Metarhizium pingshaense in African Aedes aegypti.Environmental microbiology reports · 2024Article
- The effect of repeat feeding on dengue virus transmission potential in Wolbachia-infected Aedes aegypti following extended egg quiescence.PLoS neglected tropical diseases · 2024Article
- Article
- DENV-1 Titer Impacts Viral Blocking inViruses · 2024Article
- Measuring Host Fitness Effects and Transmission of Wolbachia Strains in Aedes aegypti Mosquitoes.Methods in molecular biology (Clifton, N.J.) · 2024Article
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3 authors at 1 institution in 1 country.
Funding
Abstract
The endosymbiotic bacterium Wolbachia shows viral blocking in its mosquito host, leading to its use in arboviral disease control. Releases with Wolbachia strains wMel and wAlbB infecting Aedes aegypti have taken place in several countries. Mosquito egg survival is a key factor influencing population persistence and this trait is also important when eggs are stored prior to releases. We therefore tested the viability of mosquitoes derived from Wolbachia wMel and wAlbB-infected as well as uninfected eggs after long-term storage under diurnal temperature cycles of 11-19°C and 22-30°C. Eggs stored at 11-19°C had higher hatch proportions than those stored at 22-30°C. Adult Wolbachia density declined when they emerged from eggs stored for longer, which was associated with incomplete cytoplasmic incompatibility (CI) when wMel-infected males were crossed with uninfected females. Females from stored eggs at both temperatures continued to show perfect maternal transmission of Wolbachia, but storage reduced the fecundity of both wMel and wAlbB-infected females relative to uninfected mosquitoes. Furthermore, we found a very strong negative impact of the wAlbB infection on the fertility of females stored at 22-30°C, with almost 80% of females hatching after 11 weeks of storage being infertile. Our findings provide guidance for storing Wolbachia-infected A. aegypti eggs to ensure high fitness adult mosquitoes for release. Importantly, they also highlight the likely impact of egg quiescence on the population dynamics of Wolbachia-infected populations in the field, and the potential for Wolbachia to suppress mosquito populations through cumulative fitness costs across warm and dry periods, with expected effects on dengue transmission.
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