ArticleJournal of veterinary internal medicine2021
Effects of leukoreduction on storage lesions in whole blood and blood components of dogs.
Article in Journal of veterinary internal medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 14 citations in OpenAlex.
- Prestorage Leukoreduction of Canine Blood Products: A Critically Appraised Topic.Veterinary sciences · 2026Review
- Donor- and unit-specific factors influencing hemolysis in stored canine and feline packed red blood cells.Frontiers in veterinary science · 2026Article
- The effect on canine erythrocyte osmotic fragility under different temperature variations and storage times.BMC veterinary research · 2025Article
- Time-Dependent Changes in Malondialdehyde and Free-Hemoglobin in Leukoreduced and Non-Leukoreduced Canine Packed Red Blood Cells Units During Storage.Veterinary sciences · 2025Article
- Comparison of Hemostatic Activity in Canine Leukoreduced Cryoprecipitate, Cryopoor Plasma, and Fresh Plasma.Veterinary clinical pathology · 2025Article
- Understanding the biochemical impact of leukoreduction on canine pRBC storage: a focus on reactive oxygen species and storage lesions.Frontiers in veterinary science · 2025Article
- ZOOMICS : comparative metabolomics of red blood cells from dogs, cows, horses and donkeys during refrigerated storage for up to 42 days.Blood transfusion = Trasfusione del sangue · 2023Article
- Recent Progress in MOF-Based Electrochemical Sensors for Non-Enzymatic Glucose Detection.Molecules (Basel, Switzerland) · 2023Review
- Omics Technologies in Veterinary Medicine: Literature Review and Perspectives in Transfusion Medicine.Transfusion medicine and hemotherapy : offizielles Organ der Deutschen Gesellschaft fur Transfusionsmedizin und Immunhamatologie · 2023Review
- Evaluation of selected hematological, biochemical and oxidative stress parameters in stored canine CPDA-1 whole blood.BMC veterinary research · 2022Article
- Hemostatic Activity of Canine Never-Frozen Liquid Plasma Collected for Transfusion.Frontiers in veterinary science · 2022Article
- Effect of Leukoreduction by Pre-Storage Filtration on Coagulation Activity of Canine Plasma Collected for Transfusion.Veterinary sciences · 2021Article
- Effect of Leukoreduction on Hematobiochemical Parameters and Storage Hemolysis in Canine Whole Blood Units.Animals : an open access journal from MDPI · 2021Article
- Effects of leukoreduction on storage lesions in whole blood and blood components of dogs.Journal of veterinary internal medicine · 2021Article
- Effect of leukoreduction on the omics phenotypes of canine packed red blood cells during refrigerated storage.Journal of veterinary internal medicineArticle
- Effect of leukoreduction on the metabolism of equine packed red blood cells during refrigerated storage.Journal of veterinary internal medicineArticle
Corrections and comments
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Authors and funding
12 authors at 3 institutions in 1 country.
Funding
Abstract
backgroundLeukoreduction is a routine procedure in human transfusion medicine but is uncommon in veterinary.
objectivesTo evaluate the effect of leukoreduction on the quality of canine whole blood (WB) and blood products during storage. ANIMALS: Ten canine blood donors.
methodsThis is a case series study. An amount of 450 mL of blood was collected from each dog. Five WB and 5 packed red blood cells (pRBC) bags were divided into 2 units each: leukoreduced (LR) and non-leukoreduced (nLR). RBC count, erythrocytes' mean osmotic fragility (MOF), 2,3-diphosphoglycerate (2,3-DPG), adenosine triphosphate (ATP), percentage of hemolysis, potassium (K), lactate, glucose, and cytokines were measured weekly from day of donation (T0) to day 35 (T35); pH, coagulation times, and clotting factors were evaluated at T0 and T35 from WB and in fresh frozen plasma after 1 year of storage.
resultsLeukoreduction showed positive effects on lactate (T35: LR WB 14.42 mmol/L SD 2.71, nLR WB 22.42 mmol/L SD 1.86, LR pRBC 20.88 mmol/L SD 2.65, nLR pRBC 36.81 mmol/L SD 2.34; P < .0001), pH (T35: LR WB 6.88 SD 0.16, nLR WB 6.69 SD 0.20, P = .02; LR pRBC 6.57 SD 0.23, nLR pRBC 6.22 SD 0.11; P < .001), and K (LR pRBC 4.08 mmol/L SD 0.88, nLR pRBC 5.48 mmol/L SD 0.90; P < .001). Increasing values of IL8 were observed in nLR units during storage (T0: 4167 ± 11 888 pg/mL; T35: 6367 ± 11 612 pg/mL). CONCLUSION AND CLINICAL IMPORTANCE: LR blood units are recommended to critically ill dogs with marked inflammatory conditions.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.