Evidence map›Paper›PMID 33591591›Full record

ArticleThe EMBO journal2021

Fungal-induced glycolysis in macrophages promotes colon cancer by enhancing innate lymphoid cell secretion of IL-22.

Yanan Zhu, Tao Shi, Xia Lu, Zhen Xu, Junxing Qu, Zhiyong Zhang, Guoping Shi, Sunan Shen, Yayi Hou, Yugen Chen and 1 more

Open access · greenAbstract read
In one paragraph

Article in The EMBO journal, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 103 papers.

0numbers the graph read from it
0cells of the map it votes in
103citing papers in PubMed
9.2field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

103 citing papers in PubMed, 143 citations in OpenAlex.

  1. Review
  2. Review
  3. Review
  4. Review
  5. Review
  6. Review
  7. Article
  8. Article
  9. Detection of Fungal Translocation in Patients With Alcohol Use Disorder Using a Real-Time PCR Assay.APMIS : acta pathologica, microbiologica, et immunologica Scandinavica · 2026
    Article
  10. Article
  11. Microbiota in cancer: current understandings and future perspectives.Signal transduction and targeted therapy · 2026
    Review
  12. Review
  13. Article
  14. Article
  15. Review
  16. Review
  17. Review
  18. Article
  19. Article
  20. Review

43 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 1 country.

Yanan ZhuThe State Key Laboratory of Pharmaceutical Biotechnology & Nanjing Stomatological Hospital, Jiangsu Key Laboratory of Molecular Medicine, Division of Immunology, Medical School, Nanjing University, Nanjing, China.
Tao ShiThe State Key Laboratory of Pharmaceutical Biotechnology & Nanjing Stomatological Hospital, Jiangsu Key Laboratory of Molecular Medicine, Division of Immunology, Medical School, Nanjing University, Nanjing, China.
Xia LuThe State Key Laboratory of Pharmaceutical Biotechnology & Nanjing Stomatological Hospital, Jiangsu Key Laboratory of Molecular Medicine, Division of Immunology, Medical School, Nanjing University, Nanjing, China.
Zhen XuThe State Key Laboratory of Pharmaceutical Biotechnology & Nanjing Stomatological Hospital, Jiangsu Key Laboratory of Molecular Medicine, Division of Immunology, Medical School, Nanjing University, Nanjing, China.
Junxing QuThe State Key Laboratory of Pharmaceutical Biotechnology & Nanjing Stomatological Hospital, Jiangsu Key Laboratory of Molecular Medicine, Division of Immunology, Medical School, Nanjing University, Nanjing, China.
Zhiyong ZhangThe State Key Laboratory of Pharmaceutical Biotechnology & Nanjing Stomatological Hospital, Jiangsu Key Laboratory of Molecular Medicine, Division of Immunology, Medical School, Nanjing University, Nanjing, China.
Guoping ShiDepartment of Colorectal Surgery, The Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, China.
Sunan ShenThe State Key Laboratory of Pharmaceutical Biotechnology & Nanjing Stomatological Hospital, Jiangsu Key Laboratory of Molecular Medicine, Division of Immunology, Medical School, Nanjing University, Nanjing, China.
Yayi HouThe State Key Laboratory of Pharmaceutical Biotechnology & Nanjing Stomatological Hospital, Jiangsu Key Laboratory of Molecular Medicine, Division of Immunology, Medical School, Nanjing University, Nanjing, China.
Yugen ChenDepartment of Colorectal Surgery, The Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, China.
Tingting WangThe State Key Laboratory of Pharmaceutical Biotechnology & Nanjing Stomatological Hospital, Jiangsu Key Laboratory of Molecular Medicine, Division of Immunology, Medical School, Nanjing University, Nanjing, China.ORCID 0000-0002-2963-0888
Nanjing University · CNNanjing University of Chinese Medicine · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Incorporation of microbiome data has recently become important for prevention, diagnosis, and treatment of colorectal cancer, and several species of bacteria were shown to be associated with carcinogenesis. However, the role of commensal fungi in colon cancer remains poorly understood. Here, we report that mice lacking the c-type lectin Dectin-3 (Dectin-3

Indexed as

GlycolysisMycobiomeAnimalsCandida albicansCells, CulturedColorectal NeoplasmsHumansInterleukin-22Interleukin-7InterleukinsIntestinal MucosaLectins, C-TypeLymphocytesMacrophagesMiceMice, Inbred C57BLClec4d protein, mouseInterleukin-22Interleukin-7InterleukinsLectins, C-TypeNuclear Receptor Subfamily 1, Group F, Member 3Receptors, Aryl HydrocarbonReceptors, ImmunologicStat3 protein, mouseSTAT3 Transcription FactorCandida albicanscolorectal cancerdectin-3IL-22ILC3

Identifiers

PMID33591591
PMCPMC8167358
OpenAlexW3132774868

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.