Evidence map›Paper›PMID 33591562›Full record

ArticleReproductive sciences (Thousand Oaks, Calif.)2021

The Influence of Pregnancy on Female Prostate Morphophysiology in Gerbils (Meriones unguiculatus).

Lorranny de Jesus Gomes, Giovanna Amaral Rodrigues, Barbara Costa Malmann Medeiros, Luana Araújo Manso, Jordana Gomes Ramos, Pedro Vale de Azevedo Brito, Sebastião Roberto Taboga, Hernandes Faustino de Carvalho, Fernanda Cristina Alcantara Dos Santos, Manoel Francisco Biancardi

Erratum issuedOpen access · greenAbstract read
PubMed Publisher
In one paragraph

Article in Reproductive sciences (Thousand Oaks, Calif.), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.4field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. The Mongolian Gerbil as a Useful Experimental Model in Reproductive Biology.Reproductive sciences (Thousand Oaks, Calif.) · 2023
    Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

Lorranny de Jesus GomesDepartment of Histology, Embryology, and Cell Biology, Microscopy Laboratory Applied to Reproduction, Federal University of Goiás, Av. Esperança, s/n, Campus Samambaia, Goiânia, Goiás, 74690-900, Brazil.
Giovanna Amaral RodriguesDepartment of Histology, Embryology, and Cell Biology, Microscopy Laboratory Applied to Reproduction, Federal University of Goiás, Av. Esperança, s/n, Campus Samambaia, Goiânia, Goiás, 74690-900, Brazil.
Barbara Costa Malmann MedeirosDepartment of Histology, Embryology, and Cell Biology, Microscopy Laboratory Applied to Reproduction, Federal University of Goiás, Av. Esperança, s/n, Campus Samambaia, Goiânia, Goiás, 74690-900, Brazil.
Luana Araújo MansoDepartment of Histology, Embryology, and Cell Biology, Microscopy Laboratory Applied to Reproduction, Federal University of Goiás, Av. Esperança, s/n, Campus Samambaia, Goiânia, Goiás, 74690-900, Brazil.
Jordana Gomes RamosDepartment of Histology, Embryology, and Cell Biology, Microscopy Laboratory Applied to Reproduction, Federal University of Goiás, Av. Esperança, s/n, Campus Samambaia, Goiânia, Goiás, 74690-900, Brazil.
Pedro Vale de Azevedo BritoDepartment of Histology, Embryology, and Cell Biology, Microscopy Laboratory Applied to Reproduction, Federal University of Goiás, Av. Esperança, s/n, Campus Samambaia, Goiânia, Goiás, 74690-900, Brazil.
Sebastião Roberto TabogaDepartment of Biology, São Paulo State University, São José do Rio Preto, São Paulo, Brazil.
Hernandes Faustino de CarvalhoDepartment of Structural and Functional Biology, State University of Campinas, Campinas, São Paulo, Brazil.
Fernanda Cristina Alcantara Dos SantosDepartment of Histology, Embryology, and Cell Biology, Microscopy Laboratory Applied to Reproduction, Federal University of Goiás, Av. Esperança, s/n, Campus Samambaia, Goiânia, Goiás, 74690-900, Brazil.
Manoel Francisco BiancardiDepartment of Histology, Embryology, and Cell Biology, Microscopy Laboratory Applied to Reproduction, Federal University of Goiás, Av. Esperança, s/n, Campus Samambaia, Goiânia, Goiás, 74690-900, Brazil. manoel_biancardi@ufg.br.ORCID http://orcid.org/0000-0001-9995-3546
Universidade Federal de Goiás · BRFaculdade de Medicina de São José do Rio Preto · BRUniversidade Estadual de Campinas (UNICAMP) · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Morphophysiological changes of the female prostate during pregnancy are still little known. Considering that this gland is highly influenced by steroid hormones, the aim of this study was to evaluate the impact of the pregnancy on female prostate morphophysiology in gerbils. Pregnant females were timed, and the prostates were analyzed at pregnancy days 6 (P6), 12 (P12), 18 (P18), and 24 (P24). Virgin females were used as the control group (C). We observed a profound change in the hormonal profile during gestation, which was marked by a high oscillation of the progesterone (P4) hormone. P4 serum levels increased, peaking at the middle of gestation, and decreased to the end of the pregnancy. The morphology of the gland in pregnant females also changed, being marked by an increase of acini lumen, and a decrease in stroma. Indeed, the acinar changes during pregnancy were followed by a significant reduction of the epithelial height, besides a change of the smooth muscle cells' morphology that became more relaxed. The number of progesterone receptor (PR) and androgen receptor (AR)-positives cells decreased with the increase of progesterone serum levels, showing an inverse relationship. Finally, we observed a reduction of epithelial proliferation and a significant increase of gland PAS-positive secretion at the end of pregnancy. Altogether, these results showed, for the first time, that the female prostate morphophysioloy is profoundly influenced by the gestational period, suggesting that the fluctuation of the P4 serum levels is the main factor influencing the gland during this period.

Indexed as

AnimalsBiomarkersCell ProliferationEpithelial CellsExocrine GlandsFemaleGerbillinaeMalePregnancyProgesteroneProliferating Cell Nuclear AntigenProstateProstate-Specific AntigenReceptors, AndrogenReceptors, ProgesteroneStromal CellsBiomarkersProgesteroneProliferating Cell Nuclear AntigenProstate-Specific AntigenReceptors, AndrogenReceptors, ProgesteroneFemale prostateGerbilPregnancyProgesterone

Identifiers

PMID33591562
OpenAlexW3133227261

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.