Evidence map›Paper›PMID 33591467›Full record

ArticleJournal of cardiovascular translational research2021

Aged Monkeys Fed a High-Fat/High-Sugar Diet Recapitulate Metabolic Disorders and Cardiac Contractile Dysfunction.

Shuang Zheng, Weijiang Tan, Xiang Li, Binglin Li, Baoyong Gong, W Glen Pyle, Jian Wu, Lei Li, Ting Luo, Yunzeng Zou and 2 more

Abstract read
PubMed Publisher
In one paragraph

Article in Journal of cardiovascular translational research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
2.0field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 21 citations in OpenAlex.

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  10. The Influence of Diet on Metabolism and Health Across the Lifespan in Nonhuman Primates.Current opinion in endocrine and metabolic research · 2022
    Article
  11. Best Paper of the Year 2021.Journal of cardiovascular translational research · 2022
    Article
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

12 authors at 5 institutions in 2 countries.

Shuang Zheng *Guangdong Provincial Key Laboratory of Laboratory Animals, Guangdong Laboratory Animals Monitoring Institute, Guangzhou, China.
Weijiang Tan *Guangdong Provincial Key Laboratory of Laboratory Animals, Guangdong Laboratory Animals Monitoring Institute, Guangzhou, China.
Xiang Li *Guangdong Provincial Key Laboratory of Laboratory Animals, Guangdong Laboratory Animals Monitoring Institute, Guangzhou, China.
Binglin LiGuangdong Provincial Key Laboratory of Laboratory Animals, Guangdong Laboratory Animals Monitoring Institute, Guangzhou, China.
Baoyong GongGuangdong Provincial Key Laboratory of Laboratory Animals, Guangdong Laboratory Animals Monitoring Institute, Guangzhou, China.
W Glen PyleDepartment of Biomedical Sciences, University of Guelph, Guelph, Canada.
Jian WuShanghai Institute of Cardiovascular Diseases, Zhongshan Hospital and Institutes of Biomedical Sciences, Fudan University, Shanghai, China.
Lei LiThe Second Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.
Ting LuoGuangdong Provincial Key Laboratory of Laboratory Animals, Guangdong Laboratory Animals Monitoring Institute, Guangzhou, China.
Yunzeng ZouShanghai Institute of Cardiovascular Diseases, Zhongshan Hospital and Institutes of Biomedical Sciences, Fudan University, Shanghai, China.
Feng Hua YangGuangdong Provincial Key Laboratory of Laboratory Animals, Guangdong Laboratory Animals Monitoring Institute, Guangzhou, China. fenghua.yang@gdlami.com.ORCID 0000-0002-8571-9748
Peter H BackxDepartment of Biology, York University, Toronto, Canada. pbackx@yorku.ca.
Guangdong Laboratory Animals Monitoring Institute · CNSun Yat-sen University · CNUniversity Health Network · CAUniversity of Guelph · CAWenzhou Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Aged nonhuman primate (NHP) models are of great value for studying the pathology of metabolic heart diseases and developing therapeutic strategies. In this study, aged male cynomolgus monkeys were fed a regular diet or a high-fat/high-sugar diet (HFSD) for 8 months. Metabolic disorders were diagnosed by

Indexed as

Heart DiseasesMetabolic DiseasesAnimalsDiet, High-FatHaplorhiniMaleSugarsSugarsAged animal modelContractile functionCynomolgus monkeyHigh-fat/high-sugar dietSerum metabolomicsSignaling regulation

Identifiers

PMID33591467
OpenAlexW3132543283

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.