Evidence map›Paper›PMID 33591388›Full record

ArticleEuropean archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery2022

Comparison of two different intratympanic corticosteroid injection protocols as salvage treatments for idiopathic sudden sensorineural hearing loss.

Alexandros Andrianakis, Ulrich Moser, Peter Kiss, Clemens Holzmeister, Damianos Andrianakis, Peter Valentin Tomazic, Axel Wolf, Matthias Graupp

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Article in European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.5field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Intratympanic Triamcinolone or Dexamethasone in Sudden Sensory Neural Hearing Loss: A Randomized Clinical Trial.Indian journal of otolaryngology and head and neck surgery : official publication of the Association of Otolaryngologists of India · 2023
    Article
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Alexandros AndrianakisDepartment of Otorhinolaryngology, Head and Neck Surgery, Medical University of Graz, Graz, Austria.ORCID http://orcid.org/0000-0002-2530-9931
Ulrich MoserDepartment of Otorhinolaryngology, Head and Neck Surgery, Medical University of Graz, Graz, Austria.
Peter KissDepartment of Otorhinolaryngology, Head and Neck Surgery, Medical University of Graz, Graz, Austria.
Clemens HolzmeisterDepartment of Otorhinolaryngology, Head and Neck Surgery, Medical University of Graz, Graz, Austria.
Damianos AndrianakisInstitute of Mathematics and Scientific Computing, University of Graz, Graz, Austria.
Peter Valentin TomazicDepartment of Otorhinolaryngology, Head and Neck Surgery, Medical University of Graz, Graz, Austria. peter.tomazic@medunigraz.at.
Axel Wolf *Department of Otorhinolaryngology, Head and Neck Surgery, Medical University of Graz, Graz, Austria.
Matthias Graupp *Department of Otorhinolaryngology, Head and Neck Surgery, Medical University of Graz, Graz, Austria.
Medical University of Graz · ATUniversity of Graz · AT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeWe aimed to investigate the effect of interval length and total count of intratympanic steroid (ITS) injections in salvage treatment of patients with idiopathic sudden sensorineural hearing loss (ISSNHL).

methodsThis retrospective case-control study included 64 patients with ISSNHL, who were treated with ITS injections as salvage therapy at a tertiary referral centre. From September 2019 to December 2020, 32 patients received up to four injections every 2-4 days (revised-protocol group). These patients were 1:1 matched to patients, who received up to three injections at 1-week intervals between January 2014 and August 2019 (initial-protocol group). Hearing outcomes of the two groups were compared.

resultsBoth ITS salvage treatment protocols resulted in a statistically significant hearing improvement (p < 0.05). The initial-protocol declined hearing thresholds by 12 ± 11.7 dB (p < 0.001, d = 1, P = 99%). Mean hearing function was improved by 13.4 ± 19.1 dB in the revised-protocol group [p < 0.001, d = 0.7, P = 98%]. A clinically significant hearing improvement (> 10 dB) was seen in 18 patients (58.1%) in the initial-protocol group and in 14 patients (41.9%) in the revised-protocol group. A comparison of the hearing outcomes between protocol groups revealed no statistically significant differences (p > 0.05).

conclusionThese results indicate that a shorter injection interval does not lead to better hearing outcomes in ITS salvage treatment for ISSNHL. Moreover, fewer ITS injections may reduce costs, physical/mental stress of the patients and lower the risk of persistent tympanic perforations.

Indexed as

Hearing Loss, SensorineuralHearing Loss, SuddenAdrenal Cortex HormonesAudiometry, Pure-ToneCase-Control StudiesDexamethasoneGlucocorticoidsHumansInjection, IntratympanicRetrospective StudiesSalvage TherapyTreatment OutcomeAdrenal Cortex HormonesDexamethasoneGlucocorticoidsIdiopathic sudden sensorineural hearing lossInjection countIntervalIntratympanic steroid injectionSalvage treatment

Identifiers

PMID33591388
OpenAlexW3129813958

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.