Evidence map›Paper›PMID 33591187›Full record

ArticleMolecular pharmaceutics2021

CC Chemokine Receptor 5 Targeted Nanoparticles Imaging the Progression and Regression of Atherosclerosis Using Positron Emission Tomography/Computed Tomography.

Lisa Detering, Allison Abdilla, Hannah P Luehmann, Jesse W Williams, Li-Hao Huang, Deborah Sultan, Andrew Elvington, Gyu Seong Heo, Pamela K Woodard, Robert J Gropler and 3 more

Open access · greenAbstract read
In one paragraph

Article in Molecular pharmaceutics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
2.0field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 29 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. Review
  5. Review
  6. Review
  7. Review
  8. Review
  9. Article
  10. Nanomedicine for Diagnosis and Treatment of Atherosclerosis.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2023
    Review
  11. Review
  12. Review
  13. Review
  14. Article
  15. Review
  16. PET Imaging Radiotracers of Chemokine Receptors.Molecules (Basel, Switzerland) · 2021
    Review
  17. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 3 institutions in 1 country.

Lisa DeteringMallinckrodt Institute of Radiology, Washington University, St. Louis, Missouri 63110, United States.
Allison AbdillaMaterials Department, University of California, Santa Barbara, California 93106, United States.
Hannah P LuehmannMallinckrodt Institute of Radiology, Washington University, St. Louis, Missouri 63110, United States.
Jesse W WilliamsDepartment of Pathology and Immunology, Washington University, St. Louis, Missouri 63110, United States.
Li-Hao HuangDepartment of Pathology and Immunology, Washington University, St. Louis, Missouri 63110, United States.
Deborah SultanMallinckrodt Institute of Radiology, Washington University, St. Louis, Missouri 63110, United States.
Andrew ElvingtonDepartment of Pathology and Immunology, Washington University, St. Louis, Missouri 63110, United States.
Gyu Seong HeoMallinckrodt Institute of Radiology, Washington University, St. Louis, Missouri 63110, United States.ORCID 0000-0001-6200-4742
Pamela K WoodardMallinckrodt Institute of Radiology, Washington University, St. Louis, Missouri 63110, United States.
Robert J GroplerMallinckrodt Institute of Radiology, Washington University, St. Louis, Missouri 63110, United States.
Gwendalyn J RandolphDepartment of Pathology and Immunology, Washington University, St. Louis, Missouri 63110, United States.
Craig J HawkerMaterials Department, University of California, Santa Barbara, California 93106, United States.ORCID 0000-0001-9951-851X
Yongjian LiuMallinckrodt Institute of Radiology, Washington University, St. Louis, Missouri 63110, United States.ORCID 0000-0002-1118-1535
Mallinckrodt (United States) · USWashington University in St. Louis · USUniversity of California, Santa Barbara · US

Funding

Washington University Nutrition Obesity Research CenterP30DK056341 · NIDDK · WASHINGTON UNIVERSITY · PI Dominic N Reeds · 1999 to 2026
$30.2M
Targeted Molecular Probes for Atherosclerosis Imaging and TherapyR35HL145212 · NHLBI · WASHINGTON UNIVERSITY · PI LIU, YONGJIAN · 2019 to 2025
$5.1M
CHEMOKINE RECEPTORS BASED NANOAGENTS IMAGING ATHEROSCLEROSISR01HL125655 · NHLBI · WASHINGTON UNIVERSITY · PI LIU, YONGJIAN · 2015 to 2018
$1.5M
ATHEROSCLEROTIC LESION INITIATION BY RESIDENT AORTIC MACROPHAGE PROLIFERATIONR00HL138163 · NHLBI · UNIVERSITY OF MINNESOTA · PI WILLIAMS, JESSE WARREN · 2019 to 2021
$747k
NHLBI NIH HHS R00 HL138163NHLBI NIH HHS R01 HL125655NHLBI NIH HHS R35 HL145212NIDDK NIH HHS P30 DK056341
6 · The paper itself

Abstract

Chemokines and chemokine receptors play an important role in the initiation and progression of atherosclerosis by mediating the trafficking of inflammatory cells. Chemokine receptor 5 (CCR5) has major implications in promoting the development of plaques to advanced stage and related vulnerability. CCR5 antagonist has demonstrated the effective inhibition of atherosclerotic progression in mice, making it a potential biomarker for atherosclerosis management. To accurately determine CCR5

Indexed as

AlanineAnimalsApolipoproteins EAtherosclerosisChemokinesCopper RadioisotopesDisease Models, AnimalHumansMaleMiceMice, Inbred C57BLMice, KnockoutNanoparticlesPlaque, AtheroscleroticPositron Emission Tomography Computed TomographyRadiopharmaceuticalsAlanineApolipoproteins ECCR5 protein, mouseChemokinesCopper RadioisotopesD-Ala-peptide T-amideRadiopharmaceuticalsReceptors, CCR5atherosclerosisCCR5macrophagenanoparticlepositron emission tomography

Identifiers

PMID33591187
PMCPMC8737066
OpenAlexW3129461983

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.