ArticleAlzheimer's & dementia : the journal of the Alzheimer's Association2021
Gait variability across neurodegenerative and cognitive disorders: Results from the Canadian Consortium of Neurodegeneration in Aging (CCNA) and the Gait and Brain Study.
Article in Alzheimer's & dementia : the journal of the Alzheimer's Association, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03020381 (Gait as Predictor of Cognitive Decline, Dementia, and Risk of Falls in MCI. A Cohort Study), which is not on this map. Cited by 109 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Gait as Predictor of Cognitive Decline, Dementia, and Risk of Falls in MCI. A Cohort Study
Who cites it
109 citing papers in PubMed, 191 citations in OpenAlex.
- Synergistic effects of exercise, cognitive training and vitamin D on gait performance and falls in mild cognitive impairment-secondary outcomes from the SYNERGIC trial.Age and ageing · 2025Trial
- Instrumented Walkway Gait Analysis Predicts Fallers in Neurological Disorders: Identifying Digital Biomarkers for Balance Monitoring.Sensors (Basel, Switzerland) · 2026Article
- Enhanced Gait Variability Index in Neurological and Geriatric Rehabilitation: A Scoping Review.NeuroRehabilitation · 2026Article
- When Walking Outlasts Cognition: Rethinking the Late-Stage of Lewy Body Dementia.Neuro-degenerative diseases · 2026Review
- Early identification of vascular cognitive impairment from a multimodal perspective: a combined diagnosis from targeted cognitive assessments, imaging biomarkers, and molecular fluid biomarkers to ecological behavioral characteristics.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Review
- Olfactory dysfunction is associated with gait impairment in older adults: evidence for a shared amygdala substrate.GeroScience · 2026Article
- Gait Analysis Using Wearable Sensors in Patients With Alzheimer's Dementia: A Preliminary Report.Dementia and neurocognitive disorders · 2026Article
- Gait Analysis for Identifying Normal Cognition, Subjective Cognitive Decline, and Mild Cognitive Impairment in Parkinson Disease: Diagnostic Study.JMIR mHealth and uHealth · 2026Article
- Impact of Sleep Quality on Gait Variability: Pilot Cohort Study.JMIR aging · 2026Article
- Article
- Motor-Derived Digital Biomarkers for Identifying Low-MoCA Status in People with Parkinson's Disease.Sensors (Basel, Switzerland) · 2026Article
- Nonlinear Gait Variability and the Role of Cognitive-Physical Exercise in Mitigating Mobility Decline in Institutionalized Older Adults with Cognitive Impairment.Journal of functional morphology and kinesiology · 2026Article
- Turning versus straight walking under dual-task conditions: a preliminary study for identifying mild cognitive impairment and Alzheimer's disease.BMC neurology · 2026Article
- Article
- Development and clinical validation of a stroke-specific Gait Deviation Index.Journal of neuroengineering and rehabilitation · 2026Article
- Curve walking gait analysis using depth camera and machine learning for detecting cognitive impairment.Frontiers in neurology · 2026Article
- Gait variability as a dual-pathway marker of cognitive-motor dysfunction in older adults with type 2 diabetes mellitus.Frontiers in endocrinology · 2026Article
- A facility-based "brain gym": feasibility and preliminary effectiveness of a long-duration, low-frequency dual-task and exergaming intervention in older adults.Frontiers in psychology · 2026Article
- Toward terminological clarity in digital biomarker research.Frontiers in digital health · 2026Article
- Linking Motor and Cognitive Decline in Aging: Gait Variability and Working Memory as Early Markers of Frailty.Healthcare (Basel, Switzerland) · 2025Article
49 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
9 authors at 7 institutions in 2 countries.
Funding
Abstract
introductionGait impairment is common in neurodegenerative disorders. Specifically, gait variability-the stride-to-stride fluctuations in distance and time-has been associated with neurodegeneration and cognitive impairment. However, quantitative comparisons of gait impairments across the cognitive spectrum of dementias have not been systematically investigated.
methodsOlder adults (N = 500) with subjective cognitive impairment, Parkinson disease (PD), mild cognitive impairment (MCI), PD-MCI, Alzheimer's disease (AD), PD-dementia, Lewy body dementia, and frontotemporal dementia, as well cognitive normal controls, who were assessed for their gait and cognitive performance.
resultsFactor analyses grouped 11 quantitative gait parameters and identified four independent gait domains: rhythm, pace, variability, and postural control, for group comparisons and classification analysis. Among these domains, only high gait variability was associated with lower cognitive performance and accurately discriminated AD from other neurodegenerative and cognitive conditions. DISCUSSION: Our findings indicate that high gait variability is a marker of cognitive-cortical dysfunction, which can help to identify Alzheimer's disease dementia.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.