Evidence map›Paper›PMID 33590607›Full record

ArticleAngewandte Chemie (International ed. in English)2021

Tracking Reactions of Asymmetric Organo-Osmium Transfer Hydrogenation Catalysts in Cancer Cells.

Elizabeth M Bolitho, James P C Coverdale, Hannah E Bridgewater, Guy J Clarkson, Paul D Quinn, Carlos Sanchez-Cano, Peter J Sadler

Open access · hybridAbstract read
In one paragraph

Article in Angewandte Chemie (International ed. in English), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
2.7field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 41 citations in OpenAlex.

  1. Review
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  7. Targeting cancer lactate metabolism with synergistic combinations of synthetic catalysts and monocarboxylate transporter inhibitors.Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry · 2023
    Article
  8. Article
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  10. Single-Cell Chemistry of Photoactivatable Platinum Anticancer Complexes.Journal of the American Chemical Society · 2021
    Article
  11. Article
  12. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 2 countries.

Elizabeth M BolithoDepartment of Chemistry, University of Warwick, Coventry, CV4 7AL, UK.ORCID 0000-0003-1658-0866
James P C CoverdaleDepartment of Chemistry, University of Warwick, Coventry, CV4 7AL, UK.ORCID 0000-0002-7779-6620
Hannah E BridgewaterDepartment of Chemistry, University of Warwick, Coventry, CV4 7AL, UK.ORCID 0000-0003-1769-9025
Guy J ClarksonDepartment of Chemistry, University of Warwick, Coventry, CV4 7AL, UK.ORCID 0000-0003-3076-3191
Paul D QuinnI14 Imaging Beamline, Diamond Light Source, Oxford, OX11 0DE, UK.ORCID 0000-0002-7607-4271
Carlos Sanchez-CanoCenter for Cooperative Research in Biomaterials (CIC biomaGUNE), Basque Research and Technology Alliance (BRTA), Paseo de Miramon 182, 20014, San Sebastián, Spain.ORCID 0000-0002-9522-0019
Peter J SadlerDepartment of Chemistry, University of Warwick, Coventry, CV4 7AL, UK.ORCID 0000-0001-9160-1941
University of Warwick · GBDiamond Light Source · GBCIC biomaGUNE · ES

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Most metallodrugs are prodrugs that can undergo ligand exchange and redox reactions in biological media. Here we have investigated the cellular stability of the anticancer complex [Os

Indexed as

Antineoplastic AgentsCatalysisCell Line, TumorCell ProliferationCell SurvivalHumansHydrogenationMetal-Organic FrameworksMolecular ConformationOsmiumAntineoplastic AgentsMetal-Organic FrameworksOsmiumanticancer catalystsbioorganometallic chemistryorgano-osmium complexestransfer hydrogenationX-ray fluorescence

Identifiers

PMID33590607
PMCPMC7985874
OpenAlexW3122428684

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.