Evidence map›Paper›PMID 33590468›Full record

ArticleAging clinical and experimental research2021

Relationship between frailty and drug use among nursing homes residents: results from the SHELTER study.

Emanuele Rocco Villani, Davide Liborio Vetrano, Rosa Liperoti, Katie Palmer, Michael Denkinger, Henriëtte G van der Roest, Roberto Bernabei, Graziano Onder

Abstract read
PubMed Publisher
In one paragraph

Article in Aging clinical and experimental research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 3 pooled it
2.3field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 3 syntheses or guidelines pooled it, 23 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Observational
  11. Frailty in Parkinson's disease: A systematic review and meta-analysis.Clinical parkinsonism & related disorders · 2021
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 5 institutions in 5 countries.

Emanuele Rocco VillaniDepartment of Geriatrics, Catholic University of the Sacred Heart, Rome, Italy. Emanuele.rocco.villani@gmail.com.ORCID http://orcid.org/0000-0001-8813-2419
Davide Liborio VetranoKarolinska Institutet, Stockholm, Sweden.
Rosa LiperotiDepartment of Geriatrics, Catholic University of the Sacred Heart, Rome, Italy.
Katie PalmerDepartment of Geriatrics, Catholic University of the Sacred Heart, Rome, Italy.
Michael DenkingerAGAPLESION Bethesda Ulm, Geriatric Research Ulm University and Geriatric Center Ulm/Alb-Donau, Ulm, Germany.
Henriëtte G van der RoestDepartment on Aging, Netherlands Insititute of Mental Health and Addicition (Trimbos Insititute), Utrecht, The Netherlands.
Roberto BernabeiDepartment of Geriatrics, Catholic University of the Sacred Heart, Rome, Italy.
Graziano OnderDepartment of Cardiovascular, Endocrine-Metabolic Diseases and Aging, Istituto Superiore di Sanità, Rome, Italy.
Università Cattolica del Sacro Cuore · ITAgaplesion Bethesda Klinik · DEIstituto Superiore di Sanità · ITKarolinska Institutet · SETrimbos Institute · NL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

background1.5-8% of older adults live in nursing homes (NHs), presenting a high prevalence of frailty and polypharmacy.

aimsTo investigate the association of frailty with polypharmacy and drug prescription patterns in a sample of European Nursing Home (NH) residents.

methodsCross-sectional study based on the data from the Services and Health for Elderly in Long TERm care (SHELTER) study. 4121 NH residents in Europe and Israel. Residents' clinical, cognitive, social, and physical status were evaluated with the InterRAI LTCF tool, which allows comprehensive, standardized evaluation of persons living in NH. Polypharmacy and hyperpolypharmacy were defined as the concurrent use of ≥ 5 and ≥ 10 medications. Frailty was defined according to the FRAIL-NH scale.

resultsOf 4121 participants, 46.6% were frail (mean age 84.6 ± 9.2 years; 76.4% female). Polypharmacy and hyperpolypharmacy were associated with a lower likelihood of frailty (Odds Ratio = 0.72; 95% CI = 0.59-0.87 and OR = 0.75; 95% CI = 0.60-0.94, respectively). Patterns of drug prescriptions were different between frail and non-frail residents. Symptomatic drugs (laxatives, paracetamol, and opioids) were more frequently prescribed among frail residents, while preventive drugs (bisphosphonates, vitamin D, and acetylsalicylic acid) were more frequently prescribed among non-frail residents.

conclusionsFrailty is associated with less polypharmacy and with higher prevalence of symptomatic drugs use among NH residents. Further studies are needed to define appropriateness of drug prescription in frail individuals.

Indexed as

FrailtyPharmaceutical PreparationsAgedAged, 80 and overCross-Sectional StudiesFemaleFrail ElderlyHomes for the AgedHumansMaleNursing HomesPolypharmacyPharmaceutical PreparationsDrug useFrailtyPolypharmacy

Identifiers

PMID33590468
OpenAlexW3132074623

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.