Evidence map›Paper›PMID 33590402›Full record

ArticleJournal of neuro-oncology2021

Outcomes of salvage radiation for recurrent world health organization grade II meningiomas: a retrospective cohort study.

Arbaz A Momin, Jianning Shao, Pranay Soni, João Paulo Almeida, John H Suh, Erin S Murphy, Samuel T Chao, Lilyana Angelov, Alireza M Mohammadi, Gene H Barnett and 2 more

Abstract read
PubMed Publisher
In one paragraph

Article in Journal of neuro-oncology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
2.1field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 18 citations in OpenAlex.

  1. Trial
  2. Article
  3. Review
  4. Review
  5. Article
  6. Article
  7. Review
  8. Article
  9. Review
  10. Article
  11. Article
  12. Review
  13. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 1 institution in 1 country.

Arbaz A MominCleveland Clinic Lerner College of Medicine of Case Western Reserve University, Cleveland, OH, USA.
Jianning ShaoCleveland Clinic Lerner College of Medicine of Case Western Reserve University, Cleveland, OH, USA.
Pranay SoniDepartment of Neurosurgery, Rosa Ella Burkhardt Brain Tumor & Neuro-Oncology Center, Neurological Institute, Cleveland Clinic, Cleveland, Skull Base, Pituitary & Cerebrovascular Surgery, CLCM of CWRU, 9500 Euclid Avenue, Cleveland, OH, CA5-8644195, USA.
João Paulo AlmeidaDepartment of Neurosurgery, Rosa Ella Burkhardt Brain Tumor & Neuro-Oncology Center, Neurological Institute, Cleveland Clinic, Cleveland, Skull Base, Pituitary & Cerebrovascular Surgery, CLCM of CWRU, 9500 Euclid Avenue, Cleveland, OH, CA5-8644195, USA.
John H SuhCleveland Clinic Lerner College of Medicine of Case Western Reserve University, Cleveland, OH, USA.
Erin S MurphyCleveland Clinic Lerner College of Medicine of Case Western Reserve University, Cleveland, OH, USA.
Samuel T ChaoCleveland Clinic Lerner College of Medicine of Case Western Reserve University, Cleveland, OH, USA.
Lilyana AngelovCleveland Clinic Lerner College of Medicine of Case Western Reserve University, Cleveland, OH, USA.
Alireza M MohammadiCleveland Clinic Lerner College of Medicine of Case Western Reserve University, Cleveland, OH, USA.
Gene H BarnettCleveland Clinic Lerner College of Medicine of Case Western Reserve University, Cleveland, OH, USA.
Pablo F RecinosCleveland Clinic Lerner College of Medicine of Case Western Reserve University, Cleveland, OH, USA.
Varun R KshettryCleveland Clinic Lerner College of Medicine of Case Western Reserve University, Cleveland, OH, USA. kshettv@ccf.org.ORCID http://orcid.org/0000-0003-3217-8279
Cleveland Clinic · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeThe optimal modality of radiation-intensity-modulated radiation therapy (IMRT) or stereotactic radiosurgery (SRS)-in patients with recurrent WHO grade II meningiomas is not well-established. The purpose of this study was to compare progression-free survival (PFS) in patients undergoing salvage IMRT vs SRS. We compared PFS in those with and without history of prior radiation.

methodsForty-two patients with 71 tumor recurrences treated with IMRT or SRS were retrospectively reviewed. Thirty-two salvage treatments were performed on recurrent tumors never treated with prior radiation ('radiation-naïve' cohort), whereas 39 salvage treatments were performed on recurrent tumors previously treated with radiation ('re-treatment cohort').

resultsIn the 'radiation-naïve' cohort, 3-year PFS for IMRT and SRS was 68.8% and 60.7%, respectively (p = 0.61). The median tumor volume for patients treated with IMRT was significantly larger than for patients treated with SRS (5.7 vs 2.2 cm

conclusionFor salvage radiation of recurrent grade II tumors that are 'radiation-naïve', comparable 3-year PFS rates were found between IMRT and SRS, despite the IMRT group having significantly larger tumors. Salvage radiation overall was less successful in the 're-treatment' cohort compared with the 'radiation-naïve' cohort. Additionally, the effectiveness of radiation significantly declines with successive salvage radiation treatments.

Indexed as

AdultAgedCohort StudiesFemaleHumansMaleMeningeal NeoplasmsMeningiomaMiddle AgedNeoplasm Recurrence, LocalProgression-Free SurvivalRetrospective StudiesSalvage TherapyTreatment OutcomeAtypical meningiomasIntensity modulated radiotherapyProgression-free survivalSalvage radiationStereotactic radiosurgery

Identifiers

PMID33590402
OpenAlexW3131114448

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.