ArticleEsophagus : official journal of the Japan Esophageal Society2021
Stimulated saliva secretion is reduced in proton pump inhibitor-resistant severe reflux esophagitis patients.
Article in Esophagus : official journal of the Japan Esophageal Society, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 14 citations in OpenAlex.
- In females, salivary secretion was significantly lower in patients with severe reflux esophagitis than in healthy controls.Esophagus : official journal of the Japan Esophageal Society · 2024Article
- Characteristics of proton pump inhibitor-resistant severe reflux esophagitis and efficacy of vonoprazan in elderly (older than 75 years) and non-elderly groups.JGH open : an open access journal of gastroenterology and hepatology · 2024Article
- Article
- Saliva secretion is reduced in mild reflux esophagitis patients.Esophagus : official journal of the Japan Esophageal Society · 2022Article
- Determinants of reflux perception in patients with non-erosive reflux disease who have reflux-related symptoms on potassium-competitive acid blocker therapy.Esophagus : official journal of the Japan Esophageal Society · 2022Article
- Exploring the causal relationship between gastroesophageal reflux and oral lesions: A mendelian randomization study.Frontiers in genetics · 2022Article
- Comparative Study of Salivary pH, Buffer Capacity, and Flow in Patients with and without Gastroesophageal Reflux Disease.International journal of environmental research and public health · 2021Article
- Saliva secretion is reduced in proton pump inhibitor-responsive non-erosive reflux disease patients.Esophagus : official journal of the Japan Esophageal Society · 2021Article
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Authors and funding
9 authors at 2 institutions in 2 countries.
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No grant is acknowledged in the PubMed record.
Abstract
backgroundSalivary secretion in patients with proton-pump inhibitor (PPI)-resistant severe reflux esophagitis has not been examined. In this study, saliva secretion and salivary epidermal growth factor (EGF) in patients with PPI-resistant severe reflux esophagitis were investigated.
methodsWe recruited 22 PPI-resistant and 22 PPI-responsive severe reflux esophagitis patients who were not infected with Helicobacter pylori. Saliva secretion testing and esophageal manometry using high-resolution manometry were performed. Saliva secretion was assessed as follows: each patient chewed sugar-free gum for 3 min prior to endoscopy and the amount and pH of saliva as well as the pH of saliva after acid loading as an index of the acid-buffering capacity were measured. The salivary EGF concentration was assessed by ELISA.
resultsThe amount of saliva secreted was significantly lower in the PPI-resistant group than in the PPI-responsive group, with medians (25th-75th percentile) of 3.7 (2.2-6.8) and 4.9 (4.0-7.8) mL, respectively (p = 0.029). Salivary pH was significantly lower in the PPI-resistant group [6.9 (6.7-7.2)] than in the PPI-responsive group [7.2 (7.1-7.4), p = 0.001]. Salivary pH after acid loading was significantly lower in the PPI-resistant group [5.6 (5.3-5.9)] than in the PPI-responsive group [6.4 (6.1-6.5), p = 0.002]. The salivary EGF concentration was significantly higher in the PPI-resistant group [3211.5 (1865.0-4121.5)] than in the PPI-responsive group [1816.0 (1123.5-2792.3), p = 0.041]. No significant differences were observed in the proportion of esophageal motility abnormalities.
conclusionStimulated saliva secretion was reduced in PPI-resistant severe reflux esophagitis patients.
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