Evidence map›Paper›PMID 33590329›Full record

ArticleActa diabetologica2021

Risk of cause-specific death, its sex and age differences, and life expectancy in post-pancreatitis diabetes mellitus.

Jaelim Cho, Stephen J Pandol, Maxim S Petrov

Open access · greenAbstract read
In one paragraph

Article in Acta diabetologica, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
4.2field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 23 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 2 countries.

Jaelim ChoSchool of Medicine, University of Auckland, Auckland, New Zealand.
Stephen J PandolDivision of Gastroenterology, Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, CA, USA.
Maxim S PetrovSchool of Medicine, University of Auckland, Auckland, New Zealand. max.petrov@gmail.com.ORCID http://orcid.org/0000-0002-5923-9062
University of Auckland · NZCedars-Sinai Medical Center · US

Funding

The Southernearch Center for ALPD and CirrhosisP50AA011999 · NIAAA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI ANNA S. GUKOVSKAYA · 1999 to 2026
$45.8M
Vector and Human Acinar CoreP01DK098108 · NIDDK · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI PANDOL, STEPHEN J. · 2014 to 2018
$8.1M
Targeting diet-induced promotion of Kras-initiated pancreatic adenocarcinomaP01CA163200 · NCI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI PANDOL, STEPHEN J. · 2012 to 2016
$6.2M
Pathophysiology, Epidemiology, and Prevention of Pancreatogenic Diabetes - Administrative SupplementU01DK108314 · NIDDK · CEDARS-SINAI MEDICAL CENTER · PI Mark Goodarzi, Stephen J. Pandol · 2015 to 2026
$6.1M
Predicting Pancreatic Ductal Adenocarcinoma PDAC Through Artificial Intelligence Analysis of Pre Diagnostic CT Images in African AmericansR01CA260955 · NCI · CEDARS-SINAI MEDICAL CENTER · PI LI, DEBIAO, PANDOL, STEPHEN J. · 2021 to 2025
$4.8M
Southern California Clinical Center of the Type 1 Diabetes in Acute Pancreatitis ConsortiumU01DK127403 · NIDDK · CEDARS-SINAI MEDICAL CENTER · PI Mark Goodarzi, Stephen J. Pandol · 2020 to 2026
$2.5M
Targeting protein kinase D in alcoholic pancreatitisR01AA024464 · NIAAA · CEDARS-SINAI MEDICAL CENTER · PI PANDOL, STEPHEN J., YUAN, JINGZHEN · 2016 to 2020
$2.0M
BLRD VA I01 BX001484NCI NIH HHS P01 CA163200NCI NIH HHS R01 CA260955NIAAA NIH HHS P50 AA011999NIAAA NIH HHS R01 AA024464NIDDK NIH HHS P01 DK098108NIDDK NIH HHS U01 DK108314NIDDK NIH HHS U01 DK127403
6 · The paper itself

Abstract

aimsThe aim was to investigate sex- and age-stratified risks of cause-specific death and life expectancy in individuals with post-pancreatitis diabetes mellitus (PPDM).

methodsNationwide data on mortality in New Zealand were obtained. For two head-to-head comparisons (PPDM versus type 2 diabetes mellitus [T2DM]; PPDM versus type 1 diabetes mellitus [T1DM]), the groups were matched on age, sex, and calendar year of diabetes diagnosis. Multivariable Cox regression analyses were conducted to estimate risks of vascular, cancer, and non-vascular non-cancer mortality. Remaining life expectancy at age of diabetes diagnosis was estimated using the Chiang II method.

resultsA total of 15,848 individuals (1,132 PPDM, 3,396 T1DM, and 11,320 T2DM) were included. The risks of vascular mortality and non-vascular non-cancer mortality did not differ significantly between PPDM and T2DM or T1DM. PPDM was associated with a significantly higher risk of cancer mortality compared with T2DM (adjusted hazard ratio, 1.32; 95% confidence interval, 1.08-1.63) or T1DM (adjusted hazard ratio, 1.65; 95% confidence interval, 1.27-2.13). The risk of cancer mortality associated with PPDM (versus T2DM) was significantly higher in women than in men (p for interaction = 0.003). This sex difference in cancer mortality risk was also significant in the comparison between PPDM and T1DM (p for interaction = 0.006). Adults of both sexes with PPDM had the lowest remaining life expectancy (in comparison with T2DM or T1DM) up to 64 years of age.

conclusionsPeople with PPDM have a higher risk of cancer mortality compared with those with T2DM or T1DM. This is especially pronounced in women. Young and middle-aged adults with PPDM have a lower life expectancy compared with their counterparts with T2DM or T1DM.

Indexed as

Life ExpectancyAdultAgedAged, 80 and overAge FactorsCase-Control StudiesCause of DeathDiabetes Mellitus, Type 1Diabetes Mellitus, Type 2FemaleHumansMaleMiddle AgedNew ZealandPancreatitisRisk Factors

Identifiers

PMID33590329
PMCPMC9254257
OpenAlexW3133359000

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.