ArticleAnalytical and bioanalytical chemistry2021
Measurement of the alcohol biomarker phosphatidylethanol (PEth) in dried blood spots and venous blood-importance of inhibition of post-sampling formation from ethanol.
Article in Analytical and bioanalytical chemistry, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 55 citations in OpenAlex.
- Phosphatidylethanol as an outcome measure in treatment aimed at controlled drinking.Alcohol and alcoholism (Oxford, Oxfordshire) · 2024Trial
- Integrated internal standard volumetric dried blood microsampling for the quantification of phosphatidylethanol 16:0/18:1.Analytical and bioanalytical chemistry · 2026Article
- LC-MS/MS of PEth in whole blood: implementation in routine clinical chemistry.Practical laboratory medicine · 2026Article
- Connecting the Dots: Bridging Microsamples and Conventional Blood Matrices in Metabolic Biomarker Analysis.Analytical science advances · 2025Review
- Phosphatidylethanol in post-mortem blood: A comparative study of blood matrices and its stability at routine storage conditions.Journal of forensic sciences · 2025Article
- Assessment and cross-validation of calibration transferability between dried blood spot sampling devices for accurate quantification of phosphatidylethanol.Analytical and bioanalytical chemistry · 2025Article
- Interlaboratory comparison of phosphatidylethanol in dried blood spots using different sampling devices.Drug testing and analysis · 2025Article
- Volumetric dried blood spots for determination of phosphatidylethanol: Validation of a liquid chromatography tandem masspectrometry method and clinical application.Drug testing and analysis · 2025Article
- Current Status of Newborn Bloodspot Screening Worldwide 2024: A Comprehensive Review of Recent Activities (2020-2023).International journal of neonatal screening · 2024Review
- Identifying excessive chronic alcohol use with phosphatidylethanol in patients with suspected severe injury-results from the IDART study.Alcohol and alcoholism (Oxford, Oxfordshire) · 2024Article
- Phosphatidylethanol and self-reported alcohol consumption among people living with HIV in Thai Nguyen, Vietnam.Alcohol, clinical & experimental research · 2023Article
- Biomarkers of moderate alcohol intake and alcoholic beverages: a systematic literature review.Genes & nutrition · 2023Review
- Validation of the quantification of phosphatidylethanol 16:0/18:1 concentrations in TASSO-M20 devices.Alcohol, clinical & experimental research · 2023Article
- Microsampling tools for collecting, processing, and storing blood at the point-of-care.Bioengineering & translational medicine · 2023Review
- Phosphatidylethanol, ethyl glucuronide and ethanol in blood as complementary biomarkers for alcohol consumption.Journal of mass spectrometry and advances in the clinical lab · 2021Article
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Phosphatidylethanol (PEth) is a group of phospholipids formed in cell membranes following alcohol consumption by action of the enzyme phospholipase D (PLD). PEth measurement in whole blood samples is established as a specific alcohol biomarker with clinical and forensic applications. However, in blood specimens containing ethanol, formation of PEth may continue after sampling leading to falsely elevated concentrations. This study evaluated the use of dried blood spot (DBS) and microsampling specimens to avoid post-sampling formation of PEth. Filter paper cards and three commercial devices for volumetric microsampling of finger-pricked blood were assessed, using PEth-negative and PEth-positive whole blood fortified with 2 g/L ethanol. PEth (16:0/18:1) was measured by LC-MS/MS. Post-sampling formation of PEth occurred in wet blood and in the volumetric devices, but not filter paper cards, when stored at room temperature for 48 h. Addition of an inhibitor of PLD, sodium metavanadate (NaVO
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